prikaz prve stranice dokumenta MHC class II expression through a hitherto unknown pathway supports T helper cell dependent immune responses: implications for MHC class II deficiency
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MHC class II expression through a hitherto unknown pathway supports T helper cell dependent immune responses: implications for MHC class II deficiency
Blood, 107 (2006), 4; 1434-1444. urn:nbn:hr:184:886896
Buch, Thorsten; Polić, Bojan; Clausen, Bjoern E.; Weiss, Susanne; Akilli, Ozlem; Chang, Cheong-Hee; Flavell, Richard; Schulz, Ansgar; Jonjić, Stipan; Waisman, Ari; Foerster, Irmgard

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Buch, T., Polić, B., Clausen, B. E., Weiss, S., Akilli, O., Chang, C. H. ... Foerster, I. (2006). MHC class II expression through a hitherto unknown pathway supports T helper cell dependent immune responses: implications for MHC class II deficiency. Blood, 107. (4), 1434-1444. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:886896

Buch, Thorsten, et al. "MHC class II expression through a hitherto unknown pathway supports T helper cell dependent immune responses: implications for MHC class II deficiency." Blood, vol. 107, br. 4, 2006, str. 1434-1444. https://urn.nsk.hr/urn:nbn:hr:184:886896

Buch, Thorsten, Bojan Polić, Bjoern E. Clausen, Susanne Weiss, Ozlem Akilli, Cheong Hee Chang, Richard Flavell, et al. "MHC class II expression through a hitherto unknown pathway supports T helper cell dependent immune responses: implications for MHC class II deficiency." Blood 107, br. 4 (2006): 1434-1444. https://urn.nsk.hr/urn:nbn:hr:184:886896

Buch, T., et al. (2006) 'MHC class II expression through a hitherto unknown pathway supports T helper cell dependent immune responses: implications for MHC class II deficiency', Blood, 107(4), str. 1434-1444. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:886896 (Datum pristupa: 25.12.2024.)

Buch T, Polić B, Clausen BE, Weiss S, Akilli O, Chang CH, i sur.. MHC class II expression through a hitherto unknown pathway supports T helper cell dependent immune responses: implications for MHC class II deficiency. Blood [Internet]. 2006. [pristupljeno 25.12.2024.];107(4):1434-1444. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:886896

T. Buch, et al., "MHC class II expression through a hitherto unknown pathway supports T helper cell dependent immune responses: implications for MHC class II deficiency", Blood, vol. 107, br. 4, str. 1434-1444, 2006. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:886896. [Citirano: 25.12.2024.]

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Naslov (engleski)MHC class II expression through a hitherto unknown pathway supports T helper cell dependent immune responses: implications for MHC class II deficiency
Naslov (engleski)MHC class II expression through a hitherto unknown pathway supports T helper cell dependent immune responses:implications for MHC class II deficiency
AutorThorsten Buch
AutorBojan Polić
AutorBjoern E. Clausen
AutorSusanne Weiss
AutorOzlem Akilli
AutorCheong-Hee Chang
AutorRichard Flavell
AutorAnsgar Schulz
AutorStipan Jonjić
AutorAri Waisman
AutorIrmgard Foerster
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		PRIRODNE ZNANOSTI
Biologija
Sažetak (engleski)
MHC class II (MHCII) deficiency of Bare Lymphocyte Syndrome (BLS) is a severe immunodeficiency characterized by deficient T helper (Th) cell dependent immunity. The disease is caused by defects of the MHCII promoter complex resulting in low or absent MHCII expression. We demonstrate in a murine model of MHCII deficiency (RFX5- or CIITA-deficient mice) that residual MHCII expression by professional APC is sufficient to support activation of adoptively transferred Th cells. Furthermore, upon transplantation of WT thymic epithelium we observed development of endogenous Th cells with restoration of Th cell dependent antibody responses and immunity to cytomegalovirus infection, thus opening the posssibility of an alternative treatment regimen for BLS. Residual MHCII expression was further induced by the presence of Th cells and also other stimuli. Analysis of CIITA/RFX5 double deficient animals revealed that this inducible MHCII expression is genetically independent of the known promoter complex and thus constitutes an alternative MHCII expression pathway. In these experiments, we also detected a novel repressive function of the RFX complex in the absence of CIITA.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBlood
Brojčani podacivol. 107, br. 4, str. 1434-1444
p-ISSN0006-4971
URN:NBNurn:nbn:hr:184:886896
Datum objave publikacije2006
URL dokumentahttp://bib.irb.hr/212837
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2020-02-04 17:08:50