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Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins
The Journal of Cell Biology, 195 (2011), 7; 1123-1140. https://doi.org/10.1083/jcb.201108121
Sideridou, Maria; Zakopoulou, Roubini; Evangelou, Konstantinos; Liontos, Michalis; Kotsinas, Athanassios; Rampakakis, Emmanouil; Gagos, Sarantis; Kahata, Kaoru; Grabušić, Kristina; Gkouskou, Kalliopi; Trougakos, Ioannis P.; Kolettas, Evangelos; Georgakilas, Alexandros G.; Volarević, Siniša; Eliopoulos, Aristides G.; Zannis-Hadjopoulos, Maria; Moustakas, Aristidis; Gorgoulis, Vassilis G. Više autora...

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Sideridou, M., Zakopoulou, R., Evangelou, K., Liontos, M., Kotsinas, A., Rampakakis, E. ... Gorgoulis, V. G. (2011). Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins. The Journal of Cell Biology, 195. (7), 1123-1140. doi: 10.1083/jcb.201108121

Sideridou, Maria, et al. "Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins." The Journal of Cell Biology, vol. 195, br. 7, 2011, str. 1123-1140. https://doi.org/10.1083/jcb.201108121

Sideridou, Maria, Roubini Zakopoulou, Konstantinos Evangelou, Michalis Liontos, Athanassios Kotsinas, Emmanouil Rampakakis, Sarantis Gagos, et al. "Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins." The Journal of Cell Biology 195, br. 7 (2011): 1123-1140. https://doi.org/10.1083/jcb.201108121

Sideridou, M., et al. (2011) 'Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins', The Journal of Cell Biology, 195(7), str. 1123-1140. doi: 10.1083/jcb.201108121

Sideridou M, Zakopoulou R, Evangelou K, Liontos M, Kotsinas A, Rampakakis E, i sur.. Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins. The Journal of Cell Biology [Internet]. 26.12.2011. [pristupljeno 17.04.2024.];195(7):1123-1140. doi: 10.1083/jcb.201108121

M. Sideridou, et al., "Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins", The Journal of Cell Biology, vol. 195, br. 7, str. 1123-1140, Prosinac 2011. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:684626. [Citirano: 17.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:684626
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Naslov (engleski)Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins
AutorMaria Sideridou
AutorRoubini Zakopoulou
AutorKonstantinos Evangelou
AutorMichalis Liontos
AutorAthanassios Kotsinas
AutorEmmanouil Rampakakis
AutorSarantis Gagos
AutorKaoru Kahata
AutorKristina Grabušić
AutorKalliopi Gkouskou
AutorIoannis P. Trougakos
AutorEvangelos Kolettas
AutorAlexandros G. Georgakilas
AutorSiniša Volarević
AutorAristides G. Eliopoulos
AutorMaria Zannis-Hadjopoulos
AutorAristidis Moustakas
AutorVassilis G. Gorgoulis
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za molekularnu medicinu i biotehnologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
E-cadherin (CDH1) loss occurs frequently in carcinogenesis, contributing to invasion and metastasis. We observed that mouse and human epithelial cell lines overexpressing the replication licensing factor Cdc6 underwent phenotypic changes with mesenchymal features and loss of E-cadherin. Analysis in various types of human cancer revealed a strong correlation between increased Cdc6 expression and reduced E-cadherin levels. Prompted by these findings, we discovered that Cdc6 repressed CDH1 transcription by binding to the E-boxes of its promoter, leading to dissociation of the chromosomal insulator CTCF, displacement of the histone variant H2A.Z, and promoter heterochromatinization. Mutational analysis identified the Walker B motif and C-terminal region of Cdc6 as essential for CDH1 transcriptional suppression. Strikingly, CTCF displacement resulted in activation of adjacent origins of replication. These data demonstrate that Cdc6 acts as a molecular switch at the E-cadherin locus, linking transcriptional repression to activation of replication, and provide a telling example of how replication licensing factors could usurp alternative programs to fulfill distinct cellular functions.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaThe Journal of Cell Biology
Brojčani podacivol. 195, br. 7, str. 1123-1140
p-ISSN0021-9525
e-ISSN1540-8140
DOIhttps://doi.org/10.1083/jcb.201108121
URN:NBNurn:nbn:hr:184:684626
Datum objave publikacije2011-12-26
ProjektŠifra: 285948
Naziv (engleski): Enhancing University of Crete Medical School Scientific Excellence and Translational Research Potential in Human Diseases
Kratica: TRANSPOT
Pravna nadležnost: eu
Financijer: EC
Linija financiranja: FP7
ProjektŠifra: 223151
Naziv (engleski): Understanding inflammation-associated tumorigenesis for the rational design of novel anti-cancer therapeutic strategies.
Kratica: INFLA-CARE
Pravna nadležnost: eu
Financijer: EC
Linija financiranja: FP7
ProjektŠifra: 201630
Naziv (engleski): Genomic Instability in Cancer and Precancer
Kratica: GENICA
Pravna nadležnost: eu
Financijer: EC
Linija financiranja: FP7
ProjektŠifra: 062-1081347-0370
Naziv (hrvatski): Odgovor stanica sisavaca na pogrešku u sintezi ribozoma in vivo
Voditelj: Siniša Volarević
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttps://rupress.org/jcb/article/195/7/1123/50560/Cdc6-expression-represses-Ecadherin-transcription
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Dijeli pod istim uvjetima 3.0 (CC BY-NC-SA 3.0)
Datum i vrijeme pohrane2020-02-03 18:11:38