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The Divergent Intracellular Lifestyle of Francisella tularensis in Evolutionarily Distinct Host Cells
PLOS Pathogens, 11 (2015), 12; e1005208. https://doi.org/10.1371/journal.ppat.1005208
Ožanič, Mateja; Marečić, Valentina; Abu Kwaik, Yousef; Šantić, Marina

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Ožanič, M., Marečić, V., Abu Kwaik, Y. i Šantić, M. (2015). The Divergent Intracellular Lifestyle of Francisella tularensis in Evolutionarily Distinct Host Cells. PLOS Pathogens, 11. (12). doi: 10.1371/journal.ppat.1005208

Ožanič, Mateja, et al. "The Divergent Intracellular Lifestyle of Francisella tularensis in Evolutionarily Distinct Host Cells." PLOS Pathogens, vol. 11, br. 12, 2015. https://doi.org/10.1371/journal.ppat.1005208

Ožanič, Mateja, Valentina Marečić, Yousef Abu Kwaik i Marina Šantić. "The Divergent Intracellular Lifestyle of Francisella tularensis in Evolutionarily Distinct Host Cells." PLOS Pathogens 11, br. 12 (2015). https://doi.org/10.1371/journal.ppat.1005208

Ožanič, M., et al. (2015) 'The Divergent Intracellular Lifestyle of Francisella tularensis in Evolutionarily Distinct Host Cells', PLOS Pathogens, 11(12). doi: 10.1371/journal.ppat.1005208

Ožanič M, Marečić V, Abu Kwaik Y, Šantić M. The Divergent Intracellular Lifestyle of Francisella tularensis in Evolutionarily Distinct Host Cells. PLOS Pathogens [Internet]. 12.2015. [pristupljeno 25.12.2024.];11(12). doi: 10.1371/journal.ppat.1005208

M. Ožanič, V. Marečić, Y. Abu Kwaik i M. Šantić, "The Divergent Intracellular Lifestyle of Francisella tularensis in Evolutionarily Distinct Host Cells", PLOS Pathogens, vol. 11, br. 12, Prosinac 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:983258. [Citirano: 25.12.2024.]

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Naslov (engleski)The Divergent Intracellular Lifestyle of Francisella tularensis in Evolutionarily Distinct Host Cells
AutorMateja Ožanič
AutorValentina Marečić
AutorYousef Abu Kwaik
AutorMarina Šantić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Medicinska mikrobiologija
Sažetak (engleski)
Francisella tularensis isagram-negative,facultative, intracellular bacteriumthatsurvives in mammals, arthropods, and amoebae; however, macrophages are considered thekey cellsin pathogenesis oftularemia in mammals. Understanding intracellular traffickingof F.tularensis within various hostcells isindispensable toourunderstanding ofbacterialecology, intracellularadaptationto various hosts’ microenvironments, and subversion of hostcelldefenses. Withinmammalianand arthropod-derivedcells, F.tularensis transiently resides within an acidicvacuole priortoescapingtothecytosol, wherethebacteriareplicate. Incontrast,F.tularensisresidesandreplicateswithinnon-acidified,membrane-boundvacuoleswithinthetrophozoites ofamoebae. The Francisella pathogenicityisland (FPI) genes encode atype VI Secretion System (T6SS), which isindispensable forphagosomal escape of F.tularensis within mammalian andarthropod cellsand for intravacuolar growth within amoeba. In thisreview, we discuss thedivergentF. tularensis intracellular lifestyle indifferent hosts and itsrolein pathogenic evolution and intracellular proliferation within diverse hosts.
Ključne riječi (hrvatski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPLOS Pathogens
Brojčani podacivol. 11, br. 12, e1005208
e-ISSN1553-7374
DOIhttps://doi.org/10.1371/journal.ppat.1005208
URN:NBNurn:nbn:hr:184:983258
Datum objave publikacije2015-12
ProjektŠifra: 062-0621273-0950
Naziv (hrvatski): Francisella tularensis-unutarstanični život i patogeneza tularemije u miša
Voditelj: Marina Šantić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttps://dx.plos.org/10.1371/journal.ppat.1005208
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2020-01-31 13:01:30