Celiac disease or gluten enteropathy is an autoimmune disorder. It occurs in genetically predisposed individuals who develop an immune reaction to gluten. The aim of this paper is to describe and statistically analyze the frequency of clinical manifestations and diagnostic procedures in the detection of celiac disease in children and adolescents from 0 to 18 years old at the Pediatric Clinic of KBC Rijeka. The study was conducted by a retrograde analysis of data from the medical history of the patients diagnosed in the period from 2007. to 2017. Celiac disease was diagnosed in 81 children. During the period of eleven years, among the diagnosed there were 59% boys and 41% girls. Celiac disease was diagnosed more frequently in the group of children between 0-5 years old than in all the other groups together. 44% of patients presented with atypical and 56% with typical form of celiac disease. The three most common presenting features of celiac disease were weight loss, abdominal colics and chronic diarrhea. Villous atrophy was found in 87.65% of patients, elevated transglutaminase in 83.95% of patients and the HLA DQ2/8 gene in 27.16%. Only five patients had negative serum values of tissue transglutaminase , while the others all had positive values. Using MARSH classification, the highest percentage of patients(48%) was classified as type III. The obtained results implied the need for conducting more similar analyses in other hospitals in the Republic of Croatia where celiac disease is diagnosed, treated and monitored, with a goal to enhance comprehensive care.