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Virus Induced Interferon-ff Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity
Immunity, 49 (2018), 1; 164-177. https://doi.org/10.1016/j.immuni.2018.05.005
Šestan, Marko; Marinović, Sonja; Kavazović, Inga; Cekinović, Đurđica; Wueest, Stephan; Turk Wensveen, Tamara; Brizić, Ilija; Jonjić, Stipan; Konrad, Daniel; Wensveen, Felix M; Polić, Bojan

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Šestan, M., Marinović, S., Kavazović, I., Cekinović, Đ., Wueest, S., Turk Wensveen, T. ... Polić, B. (2018). Virus Induced Interferon-ff Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity. Immunity, 49. (1), 164-177. doi: 10.1016/j.immuni.2018.05.005

Šestan, Marko, et al. "Virus Induced Interferon-ff Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity." Immunity, vol. 49, br. 1, 2018, str. 164-177. https://doi.org/10.1016/j.immuni.2018.05.005

Šestan, Marko, Sonja Marinović, Inga Kavazović, Đurđica Cekinović, Stephan Wueest, Tamara Turk Wensveen, Ilija Brizić, et al. "Virus Induced Interferon-ff Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity." Immunity 49, br. 1 (2018): 164-177. https://doi.org/10.1016/j.immuni.2018.05.005

Šestan, M., et al. (2018) 'Virus Induced Interferon-ff Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity', Immunity, 49(1), str. 164-177. doi: 10.1016/j.immuni.2018.05.005

Šestan M, Marinović S, Kavazović I, Cekinović Đ, Wueest S, Turk Wensveen T, i sur.. Virus Induced Interferon-ff Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity. Immunity [Internet]. 2018. [pristupljeno 12.11.2024.];49(1):164-177. doi: 10.1016/j.immuni.2018.05.005

M. Šestan, et al., "Virus Induced Interferon-ff Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity", Immunity, vol. 49, br. 1, str. 164-177, 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:599545. [Citirano: 12.11.2024.]

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Naslov (engleski)Virus Induced Interferon-ff Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity
AutorMarko Šestan
AutorSonja Marinović
AutorInga Kavazović
AutorĐurđica Cekinović
AutorStephan Wueest
AutorTamara Turk Wensveen
AutorIlija Brizić
AutorStipan Jonjić
AutorDaniel Konrad
AutorFelix M Wensveen
AutorBojan Polić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Pro-inflammatory cytokines of a T helper-1-signature are known to promote insulin resistance (IR) in obesity, but the physiological role of this mechanism is unclear. It is also unknown whether and how viral infection induces loss of glycemic control in subjects at risk for developing diabetes mellitus type 2 (DM2). We have found in mice and humans that viral infection caused short-term systemic IR. Virally-induced interferon-γ (IFN-γ) directly targeted skeletal muscle to downregulate the insulin receptor but did not cause loss of glycemic control because of a compensatory increase of insulin production. Hyperinsulinemia enhanced antiviral immunity through direct stimulation of CD8+ effector T cell function. In pre-diabetic mice with hepatic IR caused by diet-induced obesity, infection resulted in loss of glycemic control. Thus, upon pathogen encounter, the immune system transiently reduces insulin sensitivity of skeletal muscle to induce hyperinsulinemia and promote antiviral immunity, which derails to glucose intolerance in pre-diabetic obese subjects. . VIDEO ABSTRACT
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaImmunity
Brojčani podacivol. 49, br. 1, str. 164-177, e6
p-ISSN1074-7613
e-ISSN1097-4180
DOIhttps://doi.org/10.1016/j.immuni.2018.05.005
URN:NBNurn:nbn:hr:184:599545
Datum objave publikacije2018
ProjektŠifra: N/A
Naziv (hrvatski): Centar izvrsnosti za virusnu imunologiju i cjepiva
Naziv (engleski): Centre of Excellence for Research in Viral Immunology and the Development of New Vaccines
Kratica: CERVirVac
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZCI
ProjektŠifra: IP-2016-06-8027
Naziv (hrvatski): Preuređivanje memorije: Manipuliranje T-staničnom memorijom u svrhu unapređenja učinkovitosti cjepiva
Naziv (engleski): Rewriting memory; Manipulation of T cell memory to enhance vaccine efficiency
Kratica: T-MEMORY
Voditelj: Felix Martinus Wensveen
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
ProjektŠifra: IP-2016-06-9306
Naziv (hrvatski): Imunosni mehanizmi u razvoju upale i metaboličkog sindroma u debljini
Naziv (engleski): Immune mechanisms in development of inflammation and metabolic syndrome in obesity
Kratica: INFLAMETAB
Voditelj: Bojan Polić
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
ProjektŠifra: KK.011.1.01.0006
Naziv (engleski): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Voditelj: Stipan Jonjić
Pravna nadležnost: eu
Financijer: ERDF
URL dokumentahttps://doi.org/10.1016/j.immuni.2018.05.005
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2019-11-12 16:26:33