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Hypovitaminosis D Influences the Clinical Presentation of Immune Thrombocytopenia in Children with Newly Diagnosed Disease
Journal of Clinical Medicine, 8 (2019), 11; 1861. https://doi.org/10.3390/jcm8111861
Petrović, Davor; Benzon, Benjamin; Batinić, Marijan; Culić, Srđana; Roganović, Jelena; Markić, Joško

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Petrović, D., Benzon, B., Batinić, M., Culić, S., Roganović, J. i Markić, J. (2019). Hypovitaminosis D Influences the Clinical Presentation of Immune Thrombocytopenia in Children with Newly Diagnosed Disease. Journal of Clinical Medicine, 8. (11). doi: 10.3390/jcm8111861

Petrović, Davor, et al. "Hypovitaminosis D Influences the Clinical Presentation of Immune Thrombocytopenia in Children with Newly Diagnosed Disease." Journal of Clinical Medicine, vol. 8, br. 11, 2019. https://doi.org/10.3390/jcm8111861

Petrović, Davor, Benjamin Benzon, Marijan Batinić, Srđana Culić, Jelena Roganović i Joško Markić. "Hypovitaminosis D Influences the Clinical Presentation of Immune Thrombocytopenia in Children with Newly Diagnosed Disease." Journal of Clinical Medicine 8, br. 11 (2019). https://doi.org/10.3390/jcm8111861

Petrović, D., et al. (2019) 'Hypovitaminosis D Influences the Clinical Presentation of Immune Thrombocytopenia in Children with Newly Diagnosed Disease', Journal of Clinical Medicine, 8(11). doi: 10.3390/jcm8111861

Petrović D, Benzon B, Batinić M, Culić S, Roganović J, Markić J. Hypovitaminosis D Influences the Clinical Presentation of Immune Thrombocytopenia in Children with Newly Diagnosed Disease. Journal of Clinical Medicine [Internet]. 03.11.2019. [pristupljeno 04.12.2024.];8(11). doi: 10.3390/jcm8111861

D. Petrović, B. Benzon, M. Batinić, S. Culić, J. Roganović i J. Markić, "Hypovitaminosis D Influences the Clinical Presentation of Immune Thrombocytopenia in Children with Newly Diagnosed Disease", Journal of Clinical Medicine, vol. 8, br. 11, Studeni 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:275062. [Citirano: 04.12.2024.]

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Podaci o radu
Naslov (engleski)Hypovitaminosis D Influences the Clinical Presentation of Immune Thrombocytopenia in Children with Newly Diagnosed Disease
AutorDavor Petrović
AutorBenjamin Benzon
AutorMarijan Batinić
AutorSrđana Culić
AutorJelena Roganović
AutorJoško Markić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za pedijatriju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Pedijatrija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Immune thrombocytopenia (ITP) is an acquired autoimmune disorder characterized by isolated thrombocytopenia defined as platelet count in peripheral blood <100 × 109/L. Hypovitaminosis D is very common in children with autoimmune diseases. To analyze whether hypovitaminosis D is associated with the clinical presentation of ITP in children, medical records of 45 pediatric patients with newly diagnosed immune thrombocytopenia in the coastal region of Croatia were evaluated. The severity of bleeding was assessed using two bleeding scores. Children with lower 25-hydroxyvitamin D (25(OH)D) values had higher values of the skin-mucosa-organ-gradation (SMOG) bleeding score and respectively more severe bleeding on diagnosis of ITP. With further analysis of the main domains of that score, we found that patients with a lower 25(OH)D value had more severe bleeding in the skin and organs. When 25(OH)D and ITP Bleeding Scale (IBLS) score were analyzed, a negative correlation was found, but it was not significant. Our findings suggest that hypovitaminosis D influences the severity of the clinical presentation of ITP in children on initial diagnosis of the disease. Therefore, therapy with 25(OH)D could be a new potential option for treatment of ITP. To investigate the connection between 25(OH)D and the incidence and severity of ITP, further studies, especially randomized controlled studies, are needed.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Clinical Medicine
Brojčani podacivol. 8, br. 11, 1861
e-ISSN2077-0383
DOIhttps://doi.org/10.3390/jcm8111861
URN:NBNurn:nbn:hr:184:275062
Datum objave publikacije2019-11-03
URL dokumentahttps://www.mdpi.com/2077-0383/8/11/1861
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2019-11-07 16:35:55