prikaz prve stranice dokumenta Vitamin D-binding protein (rs4588) T/T genotype is associated with anteroseptal myocardial infarction in coronary artery disease patients
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Vitamin D-binding protein (rs4588) T/T genotype is associated with anteroseptal myocardial infarction in coronary artery disease patients
Annals of Translational Medicine, 7 (2019), 16; 374. https://doi.org/10.21037/atm.2019.07.49
Peršić, Viktor; Raljević, Damir; Markova-Car, Elitza; Cindrić, Leon; Miškulin, Rajko; Žuvić, Marta; Pavelić, Sandra Kraljević

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Peršić, V., Raljević, D., Markova Car, E., Cindrić, L., Miškulin, R., Žuvić, M. i Pavelić, S. K. (2019). Vitamin D-binding protein (rs4588) T/T genotype is associated with anteroseptal myocardial infarction in coronary artery disease patients. Annals of Translational Medicine, 7. (16), 374. doi: 10.21037/atm.2019.07.49

Peršić, Viktor, et al. "Vitamin D-binding protein (rs4588) T/T genotype is associated with anteroseptal myocardial infarction in coronary artery disease patients." Annals of Translational Medicine, vol. 7, br. 16, 2019, str. 374. https://doi.org/10.21037/atm.2019.07.49

Peršić, Viktor, Damir Raljević, Elitza Markova Car, Leon Cindrić, Rajko Miškulin, Marta Žuvić i Sandra Kraljević Pavelić. "Vitamin D-binding protein (rs4588) T/T genotype is associated with anteroseptal myocardial infarction in coronary artery disease patients." Annals of Translational Medicine 7, br. 16 (2019): 374. https://doi.org/10.21037/atm.2019.07.49

Peršić, V., et al. (2019) 'Vitamin D-binding protein (rs4588) T/T genotype is associated with anteroseptal myocardial infarction in coronary artery disease patients', Annals of Translational Medicine, 7(16), str. 374. doi: 10.21037/atm.2019.07.49

Peršić V, Raljević D, Markova Car E, Cindrić L, Miškulin R, Žuvić M, i sur.. Vitamin D-binding protein (rs4588) T/T genotype is associated with anteroseptal myocardial infarction in coronary artery disease patients. Annals of Translational Medicine [Internet]. 08.2019. [pristupljeno 02.12.2024.];7(16):374. doi: 10.21037/atm.2019.07.49

V. Peršić, et al., "Vitamin D-binding protein (rs4588) T/T genotype is associated with anteroseptal myocardial infarction in coronary artery disease patients", Annals of Translational Medicine, vol. 7, br. 16, str. 374, Kolovoz 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:867278. [Citirano: 02.12.2024.]

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Naslov (engleski)Vitamin D-binding protein (rs4588) T/T genotype is associated with anteroseptal myocardial infarction in coronary artery disease patients
AutorViktor Peršić
AutorDamir Raljević
AutorElitza Markova-Car
AutorLeon Cindrić
AutorRajko Miškulin
AutorMarta Žuvić
AutorSandra Kraljević Pavelić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Background: Cardiovascular diseases (CVD) are among leading causes of death worldwide and amongst CVD, coronary artery disease (CAD) accounts for almost half of all cardiovascular deaths as the most common cause of death in the developed world. Vitamin D and the vitamin D-binding protein (VDBP) have been studied as possible CAD pathogenesis factors but literature data provide opposing evidence on their role in CAD. Herein we aimed to present novel evidence on the association of two VDBP polymorphisms (rs4588) and (rs7041) with CAD in patients after acute myocardial infarction and study possible correlations of these polymorphisms with 25-hydroxyvitamin D [25(OH)D] serum levels. Methods: The cross-section genotyping study included 155 subjects with CAD upon acute myocardial infarct and 104 control subjects. All patients and control group were Caucasians of European descent. VDBP polymorphisms (rs4588) and (rs7041) were studied by use of RT-PCR. Liquid chromatography, tandem mass spectrometry (LC-MS/MS) method was used for measurement of vitamin D in the serum. Results: Association of the VDBP (rs4588) T/T genotype with CAD patients after acute MI and correlation of VDBP (rs4588) genotype G/G with higher levels of total vitamin D were found. No correlation of 25(OH)D serum levels with CAD were established but the multivariate logistic regression modelling enabled association of total vitamin D level and VDBP (rs4588) T/T genotype with CAD and anteroseptal myocardial infarction (ASMI) CAD occurrence. Conclusions: Obtained data speak in favor to the VDBP (rs4588) T/T genotype as a susceptibility factor for anteroseptal myocardial infarction where the same genotype showed to be generally more prevalent in smokers
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaAnnals of Translational Medicine
Brojčani podacivol. 7, br. 16, str. 374
p-ISSN2305-5839
e-ISSN2305-5847
DOIhttps://doi.org/10.21037/atm.2019.07.49
URN:NBNurn:nbn:hr:184:867278
Datum objave publikacije2019-08
URL dokumentahttp://atm.amegroups.com/article/view/28032/25135
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 3.0 (CC BY-NC 3.0)
Datum i vrijeme pohrane2019-11-07 16:16:53