prikaz prve stranice dokumenta Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, m153
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Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, m153
Journal of Biological Chemistry, 282 (2007), 48; 35247-35258. https://doi.org/10.1074/jbc.M706782200
Mans, Janet; Natarajan, Kannan; Balbo, Andrea; Schuck, Peter; Eikel, Daniel; Hess, Sonja; Robinson, Howard; Šimić, Hrvoje; Jonjić, Stipan; Tiemessen, Caroline T.; Margulies, David H.

Citirajte ovaj rad

Mans, J., Natarajan, K., Balbo, A., Schuck, P., Eikel, D., Hess, S. ... Margulies, D. H. (2007). Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, m153. Journal of Biological Chemistry, 282. (48), 35247-35258. doi: 10.1074/jbc.M706782200

Mans, Janet, et al. "Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, m153." Journal of Biological Chemistry, vol. 282, br. 48, 2007, str. 35247-35258. https://doi.org/10.1074/jbc.M706782200

Mans, Janet, Kannan Natarajan, Andrea Balbo, Peter Schuck, Daniel Eikel, Sonja Hess, Howard Robinson, et al. "Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, m153." Journal of Biological Chemistry 282, br. 48 (2007): 35247-35258. https://doi.org/10.1074/jbc.M706782200

Mans, J., et al. (2007) 'Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, m153', Journal of Biological Chemistry, 282(48), str. 35247-35258. doi: 10.1074/jbc.M706782200

Mans J, Natarajan K, Balbo A, Schuck P, Eikel D, Hess S, i sur.. Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, m153. Journal of Biological Chemistry [Internet]. 30.11.2007. [pristupljeno 06.05.2024.];282(48):35247-35258. doi: 10.1074/jbc.M706782200

J. Mans, et al., "Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, m153", Journal of Biological Chemistry, vol. 282, br. 48, str. 35247-35258, Studeni 2007. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:518082. [Citirano: 06.05.2024.]

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Podaci o radu
Naslov (engleski)Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, m153
AutorJanet Mans
AutorKannan Natarajan
AutorAndrea Balbo
AutorPeter Schuck
AutorDaniel Eikel
AutorSonja Hess
AutorHoward Robinson
AutorHrvoje Šimić
AutorStipan Jonjić
AutorCaroline T. Tiemessen
AutorDavid H. Margulies
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Mouse cytomegalovirus (MCMV), a β-herpesvirus that establishes latent and persistent infections in mice, is a valuable model for studying complex virus-host interactions. MCMV encodes the m145 family of putative immunoevasins with predicted MHC-I structure. Functions attributed to some family members include downregulation of host MHC-I (m152) and NKG2D ligands (m145, m152, m155) and interaction with inhibitory or activating NK receptors (m157). We present the cellular, biochemical and structural characterization of m153, which is a heavily glycosylated homodimer, that does not require β2m or peptide, and is expressed at the surface of MCMV-infected cells. Its 2.4 Å crystal structure confirms that this compact molecule preserves an MHC-I-like fold and reveals a novel mode of dimerization, confirmed by site-directed mutagenesis, and a distinctive disulfide-stabilized extended amino terminus. The structure provides a useful framework for comparative analysis of the divergent members of the m145 family.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaJournal of Biological Chemistry
Brojčani podacivol. 282, br. 48, str. 35247-35258
p-ISSN0021-9258
e-ISSN1083-351X
DOIhttps://doi.org/10.1074/jbc.M706782200
URN:NBNurn:nbn:hr:184:518082
Datum objave publikacije2007-11-30
Datum objave publikacije2007-09-26
URL dokumentahttp://www.jbc.org/lookup/doi/10.1074/jbc.M706782200
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2019-04-10 06:24:42