prikaz prve stranice dokumenta Simple predictors of the re- occurrence of severe febrile neutropenia episode: a single-center retrospective cohort study in pediatric patients with malignant diseases
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Simple predictors of the re- occurrence of severe febrile neutropenia episode: a single-center retrospective cohort study in pediatric patients with malignant diseases
Croatian Medical Journal, 60 (2019), 1; 20-25. https://doi.org/10.3325/cmj.2019.60.20
Šegulja, Silvije; Ružić, Alen; Dujmić, Dora; Baždarić, Ksenija; Roganović, Jelena

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Šegulja, S., Ružić, A., Dujmić, D., Baždarić, K. i Roganović, J. (2019). Simple predictors of the re- occurrence of severe febrile neutropenia episode: a single-center retrospective cohort study in pediatric patients with malignant diseases. Croatian Medical Journal, 60. (1), 20-25. doi: 10.3325/cmj.2019.60.20

Šegulja, Silvije, et al. "Simple predictors of the re- occurrence of severe febrile neutropenia episode: a single-center retrospective cohort study in pediatric patients with malignant diseases." Croatian Medical Journal, vol. 60, br. 1, 2019, str. 20-25. https://doi.org/10.3325/cmj.2019.60.20

Šegulja, Silvije, Alen Ružić, Dora Dujmić, Ksenija Baždarić i Jelena Roganović. "Simple predictors of the re- occurrence of severe febrile neutropenia episode: a single-center retrospective cohort study in pediatric patients with malignant diseases." Croatian Medical Journal 60, br. 1 (2019): 20-25. https://doi.org/10.3325/cmj.2019.60.20

Šegulja, S., et al. (2019) 'Simple predictors of the re- occurrence of severe febrile neutropenia episode: a single-center retrospective cohort study in pediatric patients with malignant diseases', Croatian Medical Journal, 60(1), str. 20-25. doi: 10.3325/cmj.2019.60.20

Šegulja S, Ružić A, Dujmić D, Baždarić K, Roganović J. Simple predictors of the re- occurrence of severe febrile neutropenia episode: a single-center retrospective cohort study in pediatric patients with malignant diseases. Croatian Medical Journal [Internet]. 02.2019. [pristupljeno 28.12.2024.];60(1):20-25. doi: 10.3325/cmj.2019.60.20

S. Šegulja, A. Ružić, D. Dujmić, K. Baždarić i J. Roganović, "Simple predictors of the re- occurrence of severe febrile neutropenia episode: a single-center retrospective cohort study in pediatric patients with malignant diseases", Croatian Medical Journal, vol. 60, br. 1, str. 20-25, Veljača 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:306862. [Citirano: 28.12.2024.]

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Naslov (engleski)Simple predictors of the re- occurrence of severe febrile neutropenia episode: a single-center retrospective cohort study in pediatric patients with malignant diseases
AutorSilvije Šegulja
AutorAlen Ružić
AutorDora Dujmić
AutorKsenija Baždarić
AutorJelena Roganović
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku informatiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Aim To identify the risk factors of a repeated episode of severe febrile neutropenia (FN) and to build an accurate and easy-to-use predictive model. Methods This single-center retrospective cohort study conducted at the Clinical Hospital Center Children’s Hospital Rijeka from January 1, 2008 to December 31, 2016 included pediatric patients with malignant diseases who experienced at least one FN episode. The association of the second severe FN episode appearance with relevant clinical and laboratory data was analyzed by logistic regression. Results Out of 45 patients with one FN episode, 25 (56%) had severe FN and 11 (24%) had repeated severe FNs. Significant predictors of a repeated severe FN episode were the first FN episode duration of 9 or more days and red blood cells ≤3.0 × 1012/L. The predictive model constructed by crossing these two indicators had the accuracy of 87% (95% confidence interval [CI] 73%-94%), sensitivity of 82% (95% CI 53%-97%), and specificity of 88% (95% CI 79%-93%). Conclusion The first FN episode duration and anemia are significantly associated with the risk for severe FN re-occurrence. These factors may be useful in the identification of children with cancer who are at high risk for adverse outcome at any future fever onset and may benefit from early intensive treatment.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian Medical Journal
Brojčani podacivol. 60, br. 1, str. 20-25
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2019.60.20
URN:NBNurn:nbn:hr:184:306862
Datum objave publikacije2019-02
URL dokumentahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406065/
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2019-04-03 15:23:16