prikaz prve stranice dokumenta Preexposure to Olive Oil Polyphenols Extract Increases Oxidative Load and Improves Liver Mass Restoration after Hepatectomy in Mice via Stress-Sensitive Genes
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Preexposure to Olive Oil Polyphenols Extract Increases Oxidative Load and Improves Liver Mass Restoration after Hepatectomy in Mice via Stress-Sensitive Genes
Oxidative Medicine and Cellular Longevity, 2016 (2016); 1-13. https://doi.org/10.1155/2016/9191407
Marinić, Jelena; Broznić, Dalibor; Milin, Čedomila

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Marinić, J., Broznić, D. i Milin, Č. (2016). Preexposure to Olive Oil Polyphenols Extract Increases Oxidative Load and Improves Liver Mass Restoration after Hepatectomy in Mice via Stress-Sensitive Genes. Oxidative Medicine and Cellular Longevity, 2016., 1-13. doi: 10.1155/2016/9191407

Marinić, Jelena, et al. "Preexposure to Olive Oil Polyphenols Extract Increases Oxidative Load and Improves Liver Mass Restoration after Hepatectomy in Mice via Stress-Sensitive Genes." Oxidative Medicine and Cellular Longevity, vol. 2016, 2016, str. 1-13. https://doi.org/10.1155/2016/9191407

Marinić, Jelena, Dalibor Broznić i Čedomila Milin. "Preexposure to Olive Oil Polyphenols Extract Increases Oxidative Load and Improves Liver Mass Restoration after Hepatectomy in Mice via Stress-Sensitive Genes." Oxidative Medicine and Cellular Longevity 2016 (2016): 1-13. https://doi.org/10.1155/2016/9191407

Marinić, J., Broznić, D. i Milin, Č. (2016) 'Preexposure to Olive Oil Polyphenols Extract Increases Oxidative Load and Improves Liver Mass Restoration after Hepatectomy in Mice via Stress-Sensitive Genes', Oxidative Medicine and Cellular Longevity, 2016, str. 1-13. doi: 10.1155/2016/9191407

Marinić J, Broznić D, Milin Č. Preexposure to Olive Oil Polyphenols Extract Increases Oxidative Load and Improves Liver Mass Restoration after Hepatectomy in Mice via Stress-Sensitive Genes. Oxidative Medicine and Cellular Longevity [Internet]. 2016. [pristupljeno 14.11.2024.];2016:1-13. doi: 10.1155/2016/9191407

J. Marinić, D. Broznić i Č. Milin, "Preexposure to Olive Oil Polyphenols Extract Increases Oxidative Load and Improves Liver Mass Restoration after Hepatectomy in Mice via Stress-Sensitive Genes", Oxidative Medicine and Cellular Longevity, vol. 2016, str. 1-13, 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:696066. [Citirano: 14.11.2024.]

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Naslov (engleski)Preexposure to Olive Oil Polyphenols Extract Increases Oxidative Load and Improves Liver Mass Restoration after Hepatectomy in Mice via Stress-Sensitive Genes
AutorJelena Marinić
AutorDalibor Broznić
AutorČedomila Milin
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku kemiju, biokemiju i kliničku kemiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Medicinska biokemija
Sažetak (engleski)
Polyphenols can act as oxidants in some conditions, inducing redox-sensitive genes. We investigated the effect of preexposure to the olive oil polyphenols extract (PFE) on time-dependent changes in the hepatic oxidative state in a model of liver regeneration—a process in which oxidative stress associated with the metabolic overload accounts for the early events that contribute to the onset of liver self-repair. Liver regeneration was induced by one-third hepatectomy in mice. Prior to hepatectomy, mice were intraperitoneally given either PFE (50 mg/kg body weight) or saline for seven consecutive days, while respective controls received vehicle alone. Redox state-regulating enzymes and thiol proteins along with the mRNA levels of Nrf2 gene and its targets -glutamylcysteine synthetase and heme oxygenase-1 were determined at different time intervals after hepatectomy. The liver mass restoration was calculated to assess hepatic regeneration. The resulting data demonstrate the effectiveness of preexposure to PFE in stimulating liver regeneration in a model of a small tissue loss which may be ascribed to the transient increase in oxidant load during the first hours after hepatectomy and associated induction of stress response gene-profiles under the control of Nrf2.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaOxidative Medicine and Cellular Longevity
Brojčani podacivol. 2016, str. 1-13
p-ISSN1942-0900
e-ISSN1942-0994
DOIhttps://doi.org/10.1155/2016/9191407
URN:NBNurn:nbn:hr:184:696066
Datum objave publikacije2016
URL dokumentahttp://www.hindawi.com/journals/omcl/2016/9191407/
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2019-04-02 09:09:36