prikaz prve stranice dokumenta NKT Cell-TCR Expression Activates Conventional T Cells in Vivo, but Is Largely Dispensable for Mature NKT Cell Biology
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NKT Cell-TCR Expression Activates Conventional T Cells in Vivo, but Is Largely Dispensable for Mature NKT Cell Biology
PLoS Biology, 11 (2013), 6; e1001589. https://doi.org/10.1371/journal.pbio.1001589
Vahl, J. Christoph; Heger, Klaus; Knies, Nathalie; Hein, Marco Y.; Boon, Louis; Yagita, Hideo; Polić, Bojan; Schmidt-Supprian, Marc

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Vahl, J. C., Heger, K., Knies, N., Hein, M. Y., Boon, L., Yagita, H. ... Schmidt Supprian, M. (2013). NKT Cell-TCR Expression Activates Conventional T Cells in Vivo, but Is Largely Dispensable for Mature NKT Cell Biology. PLoS Biology, 11. (6). doi: 10.1371/journal.pbio.1001589

Vahl, J. Christoph, et al. "NKT Cell-TCR Expression Activates Conventional T Cells in Vivo, but Is Largely Dispensable for Mature NKT Cell Biology." PLoS Biology, vol. 11, br. 6, 2013. https://doi.org/10.1371/journal.pbio.1001589

Vahl, J. Christoph, Klaus Heger, Nathalie Knies, Marco Y. Hein, Louis Boon, Hideo Yagita, Bojan Polić i Marc Schmidt Supprian. "NKT Cell-TCR Expression Activates Conventional T Cells in Vivo, but Is Largely Dispensable for Mature NKT Cell Biology." PLoS Biology 11, br. 6 (2013). https://doi.org/10.1371/journal.pbio.1001589

Vahl, J. C., et al. (2013) 'NKT Cell-TCR Expression Activates Conventional T Cells in Vivo, but Is Largely Dispensable for Mature NKT Cell Biology', PLoS Biology, 11(6). doi: 10.1371/journal.pbio.1001589

Vahl JC, Heger K, Knies N, Hein MY, Boon L, Yagita H, i sur.. NKT Cell-TCR Expression Activates Conventional T Cells in Vivo, but Is Largely Dispensable for Mature NKT Cell Biology. PLoS Biology [Internet]. 18.06.2013. [pristupljeno 23.12.2024.];11(6). doi: 10.1371/journal.pbio.1001589

J. C. Vahl, et al., "NKT Cell-TCR Expression Activates Conventional T Cells in Vivo, but Is Largely Dispensable for Mature NKT Cell Biology", PLoS Biology, vol. 11, br. 6, Lipanj 2013. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:586710. [Citirano: 23.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:586710
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Naslov (engleski)NKT Cell-TCR Expression Activates Conventional T Cells in Vivo, but Is Largely Dispensable for Mature NKT Cell Biology
AutorJ. Christoph Vahl
AutorKlaus Heger
AutorNathalie Knies
AutorMarco Y. Hein
AutorLouis Boon
AutorHideo Yagita
AutorBojan Polić
AutorMarc Schmidt-Supprian
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Natural killer T (NKT) cell development depends on recognition of self-glycolipids via their semi-invariant Vα14i-TCR. However, to what extent TCR-mediated signals determine identity and function of mature NKT cells remains incompletely understood. To address this issue, we developed a mouse strain allowing conditional Vα14i-TCR expression from within the endogenous Tcrα locus. We demonstrate that naïve T cells are activated upon replacement of their endogenous TCR repertoire with Vα14i-restricted TCRs, but they do not differentiate into NKT cells. On the other hand, induced TCR ablation on mature NKT cells did not affect their lineage identity, homeostasis, or innate rapid cytokine secretion abilities. We therefore propose that peripheral NKT cells become unresponsive to and thus are independent of their autoreactive TCR.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPLoS Biology
Brojčani podacivol. 11, br. 6, e1001589
e-ISSN1545-7885
DOIhttps://doi.org/10.1371/journal.pbio.1001589
URN:NBNurn:nbn:hr:184:586710
Datum objave publikacije2013-06-18
URL dokumentahttps://dx.plos.org/10.1371/journal.pbio.1001589
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2018-11-30 07:10:32