prikaz prve stranice dokumenta Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress
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Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress
Proceedings of the National Academy of Sciences, 109 (2012), 50; 20467-20472. https://doi.org/10.1073/pnas.1218535109
Bursać, Slađana; Brdovčak Cokarić, Maja; Pfannkuchen, Martin; Oršolic, Ines; Golomb, L.; Zhu, Y.; Katz, C.; Daftuar, L.; Grabušić, Kristina; Vukelić, Iva; Filić, Vedrana; Oren, M.; Prives, C.; Volarević, Siniša

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Bursać, S., Brdovčak Cokarić, M., Pfannkuchen, M., Oršolic, I., Golomb, L., Zhu, Y. ... Volarević, S. (2012). Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress. Proceedings of the National Academy of Sciences, 109. (50), 20467-20472. doi: 10.1073/pnas.1218535109

Bursać, Slađana, et al. "Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress." Proceedings of the National Academy of Sciences, vol. 109, br. 50, 2012, str. 20467-20472. https://doi.org/10.1073/pnas.1218535109

Bursać, Slađana, Maja Brdovčak Cokarić, Martin Pfannkuchen, Ines Oršolic, L. Golomb, Y. Zhu, C. Katz, et al. "Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress." Proceedings of the National Academy of Sciences 109, br. 50 (2012): 20467-20472. https://doi.org/10.1073/pnas.1218535109

Bursać, S., et al. (2012) 'Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress', Proceedings of the National Academy of Sciences, 109(50), str. 20467-20472. doi: 10.1073/pnas.1218535109

Bursać S, Brdovčak Cokarić M, Pfannkuchen M, Oršolic I, Golomb L, Zhu Y, i sur.. Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress. Proceedings of the National Academy of Sciences [Internet]. 20.11.2012. [pristupljeno 15.04.2024.];109(50):20467-20472. doi: 10.1073/pnas.1218535109

S. Bursać, et al., "Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress", Proceedings of the National Academy of Sciences, vol. 109, br. 50, str. 20467-20472, Studeni 2012. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:046759. [Citirano: 15.04.2024.]

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Naslov (engleski)Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress
AutorSlađana Bursać
AutorMaja Brdovčak Cokarić
AutorMartin Pfannkuchen
AutorInes Oršolic
AutorL. Golomb
AutorY. Zhu
AutorC. Katz
AutorL. Daftuar
AutorKristina Grabušić
AutorIva Vukelić
AutorVedrana Filić
AutorM. Oren
AutorC. Prives
AutorSiniša Volarević
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za molekularnu medicinu i biotehnologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Impairment of ribosomal biogenesis can activate the p53 protein independently of DNA damage. The ability of ribosomal proteins L5, L11, L23, L26, or S7 to bind Mdm2 and inhibit its ubiquitin ligase activity has been suggested as a critical step in p53 activation under these conditions. Here, we report that L5 and L11 are particularly important for this response. Whereas several other newly synthesized ribosomal proteins are degraded by proteasomes upon inhibition of Pol I activity by actinomycin D, L5 and L11 accumulate in the ribosome-free fraction where they bind to Mdm2. This selective accumulation of free L5 and L11 is due to their mutual protection from proteasomal degradation. Furthermore, the endogenous, newly synthesized L5 and L11 continue to be imported into nucleoli even after nucleolar disruption and colocalize with Mdm2, p53, and promyelocytic leukemia protein. This suggests that the disrupted nucleoli may provide a platform for L5- and L11-dependent p53 activation, implying a role for the nucleolus in p53 activation by ribosomal biogenesis stress. These findings may have important implications with respect to understanding the pathogenesis of diseases caused by impaired ribosome biogenesis.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaProceedings of the National Academy of Sciences
Brojčani podacivol. 109, br. 50, str. 20467-20472
p-ISSN0027-8424
e-ISSN1091-6490
DOIhttps://doi.org/10.1073/pnas.1218535109
URN:NBNurn:nbn:hr:184:046759
Datum objave publikacije2012-11-20
Datum objave publikacije2012-12-11
ProjektŠifra: 062-1081347-0370
Naziv (hrvatski): Odgovor stanica sisavaca na pogrešku u sintezi ribozoma in vivo
Voditelj: Siniša Volarević
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttp://www.pnas.org/cgi/doi/10.1073/pnas.1218535109
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-11-29 22:52:29