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Gain of Virulence Caused by Loss of a Gene in Murine Cytomegalovirus
Journal of Virology, 78 (2004), 14; 7536-7544. https://doi.org/10.1128/JVI.78.14.7536-7544.2004
Bubić, Ivan; Wagner, M.; Krmpotić, Astrid; Saulig, T.; Kim, S.; Yokoyama, W. M.; Jonjić, Stipan; Koszinowski, U. H.

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Bubić, I., Wagner, M., Krmpotić, A., Saulig, T., Kim, S., Yokoyama, W. M. ... Koszinowski, U. H. (2004). Gain of Virulence Caused by Loss of a Gene in Murine Cytomegalovirus. Journal of Virology, 78. (14), 7536-7544. doi: 10.1128/JVI.78.14.7536-7544.2004

Bubić, Ivan, et al. "Gain of Virulence Caused by Loss of a Gene in Murine Cytomegalovirus." Journal of Virology, vol. 78, br. 14, 2004, str. 7536-7544. https://doi.org/10.1128/JVI.78.14.7536-7544.2004

Bubić, Ivan, M. Wagner, Astrid Krmpotić, T. Saulig, S. Kim, W. M. Yokoyama, Stipan Jonjić i U. H. Koszinowski. "Gain of Virulence Caused by Loss of a Gene in Murine Cytomegalovirus." Journal of Virology 78, br. 14 (2004): 7536-7544. https://doi.org/10.1128/JVI.78.14.7536-7544.2004

Bubić, I., et al. (2004) 'Gain of Virulence Caused by Loss of a Gene in Murine Cytomegalovirus', Journal of Virology, 78(14), str. 7536-7544. doi: 10.1128/JVI.78.14.7536-7544.2004

Bubić I, Wagner M, Krmpotić A, Saulig T, Kim S, Yokoyama WM, i sur.. Gain of Virulence Caused by Loss of a Gene in Murine Cytomegalovirus. Journal of Virology [Internet]. 25.06.2004. [pristupljeno 25.12.2024.];78(14):7536-7544. doi: 10.1128/JVI.78.14.7536-7544.2004

I. Bubić, et al., "Gain of Virulence Caused by Loss of a Gene in Murine Cytomegalovirus", Journal of Virology, vol. 78, br. 14, str. 7536-7544, Lipanj 2004. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:100329. [Citirano: 25.12.2024.]

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Podaci o radu
Naslov (engleski)Gain of Virulence Caused by Loss of a Gene in Murine Cytomegalovirus
AutorIvan Bubić
AutorM. Wagner
AutorAstrid Krmpotić
AutorT. Saulig
AutorS. Kim
AutorW. M. Yokoyama
AutorStipan Jonjić
AutorU. H. Koszinowski
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Mouse strains are either resistant or susceptible to murine cytomegalovirus (MCMV). Resistance is determined by the Cmv1r (Ly49h) gene, which encodes the Ly49H NK cell activation receptor. The protein encoded by the m157 gene of MCMV has been defined as a ligand for Ly49H. To find out whether the m157 protein is the only Ly49H ligand encoded by MCMV, we constructed the m157 deletion mutant and a revertant virus. Viruses were tested for susceptibility to NK cell control in Ly49H and Ly49H mouse strains. Deletion of the m157 gene abolished the viral activation of Ly49H NK cells, resulting in higher virus virulence in vivo. Thus, in the absence of m157, Ly49H mice react like susceptible strains. 129/SvJ mice lack the Ly49H activation NK cell receptor but express the inhibitory Ly49I NK cell receptor that binds to the m157 protein. The m157 inhibitory phenotype was weak because MCMV encodes a number of proteins that mediate NK inhibition, whose contribution could be shown by another mutant.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Virology
Brojčani podacivol. 78, br. 14, str. 7536-7544
p-ISSN0022-538X
DOIhttps://doi.org/10.1128/JVI.78.14.7536-7544.2004
URN:NBNurn:nbn:hr:184:100329
Datum objave publikacije2004-06-25
Datum objave publikacije2004-07-15
URL dokumentahttp://jvi.asm.org/cgi/doi/10.1128/JVI.78.14.7536-7544.2004
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-11-28 09:26:06