prikaz prve stranice dokumenta Non-redundant and Redundant Roles of Cytomegalovirus gH/gL Complexes in Host Organ Entry and Intra-tissue Spread
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Non-redundant and Redundant Roles of Cytomegalovirus gH/gL Complexes in Host Organ Entry and Intra-tissue Spread
PLOS Pathogens, 11 (2015), 2; e1004640. https://doi.org/10.1371/journal.ppat.1004640
Lemmermann, Niels A. W.; Krmpotić, Astrid; Podlech, Jürgen; Brizić, Ilija; Prager, Adrian; Adler, Heiko; Karbach, Astrid; Wu, Yiquan; Jonjić, Stipan; Reddehase, Matthias J.; Adler, Barbara

Citirajte ovaj rad

Lemmermann, N. A. W., Krmpotić, A., Podlech, J., Brizić, I., Prager, A., Adler, H. ... Adler, B. (2015). Non-redundant and Redundant Roles of Cytomegalovirus gH/gL Complexes in Host Organ Entry and Intra-tissue Spread. PLOS Pathogens, 11. (2). doi: 10.1371/journal.ppat.1004640

Lemmermann, Niels A. W., et al. "Non-redundant and Redundant Roles of Cytomegalovirus gH/gL Complexes in Host Organ Entry and Intra-tissue Spread." PLOS Pathogens, vol. 11, br. 2, 2015. https://doi.org/10.1371/journal.ppat.1004640

Lemmermann, Niels A. W., Astrid Krmpotić, Jürgen Podlech, Ilija Brizić, Adrian Prager, Heiko Adler, Astrid Karbach, et al. "Non-redundant and Redundant Roles of Cytomegalovirus gH/gL Complexes in Host Organ Entry and Intra-tissue Spread." PLOS Pathogens 11, br. 2 (2015). https://doi.org/10.1371/journal.ppat.1004640

Lemmermann, N. A. W., et al. (2015) 'Non-redundant and Redundant Roles of Cytomegalovirus gH/gL Complexes in Host Organ Entry and Intra-tissue Spread', PLOS Pathogens, 11(2). doi: 10.1371/journal.ppat.1004640

Lemmermann NAW, Krmpotić A, Podlech J, Brizić I, Prager A, Adler H, i sur.. Non-redundant and Redundant Roles of Cytomegalovirus gH/gL Complexes in Host Organ Entry and Intra-tissue Spread. PLOS Pathogens [Internet]. 06.02.2015. [pristupljeno 25.12.2024.];11(2). doi: 10.1371/journal.ppat.1004640

N. A. W. Lemmermann, et al., "Non-redundant and Redundant Roles of Cytomegalovirus gH/gL Complexes in Host Organ Entry and Intra-tissue Spread", PLOS Pathogens, vol. 11, br. 2, Veljača 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:358483. [Citirano: 25.12.2024.]

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Podaci o radu
Naslov (engleski)Non-redundant and Redundant Roles of Cytomegalovirus gH/gL Complexes in Host Organ Entry and Intra-tissue Spread
AutorNiels A. W. Lemmermann
AutorAstrid Krmpotić
AutorJürgen Podlech
AutorIlija Brizić
AutorAdrian Prager
AutorHeiko Adler
AutorAstrid Karbach
AutorYiquan Wu
AutorStipan Jonjić
AutorMatthias J. Reddehase
AutorBarbara Adler
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Author Summary The role of viral glycoprotein entry complexes in viral tropism in vivo is a question central to understanding virus pathogenesis and transmission for any virus. Studies were limited by the difficulty in distinguishing between viral entry into first-hit target cells and subsequent cell-to-cell spread within tissues. Employing the murine cytomegalovirus entry complex gH/gL/gO as a paradigm for a generally applicable strategy to dissect these two events experimentally, we used a gO-transcomplemented ΔgO mutant for providing the complex exclusively for the initial cell entry step. In immunocompromised mice as a model for recipients of hematopoietic cell transplantation, our studies revealed an irreplaceable role for gH/gL/gO in initiating infection in host organs relevant to pathogenesis, whereas subsequent spread within tissues and infection of the salivary glands, the site relevant to virus host-to-host transmission, are double-secured by the entry complexes gH/gL/gO and gH/gL/MCK-2. As an important consequence, interventional strategies targeting only gO might be efficient in preventing organ manifestations after a primary viremia, whereas both gH/gL complexes need to be targeted for preventing intra-tissue spread of virus reactivated from latency within tissues as well as for preventing the salivary gland route of host-to-host transmission.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPLOS Pathogens
Brojčani podacivol. 11, br. 2, e1004640
e-ISSN1553-7374
DOIhttps://doi.org/10.1371/journal.ppat.1004640
URN:NBNurn:nbn:hr:184:358483
Datum objave publikacije2015-02-06
ProjektŠifra: IP-2013-11-7132
Naziv (hrvatski): Aktivacijski receptori NK-stanica specifični za virus i njihovo izbjegavanje od strane virusa
Kratica: ViSpeNKRec
Voditelj: Astrid Krmpotić
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
URL dokumentahttps://dx.plos.org/10.1371/journal.ppat.1004640
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 3.0 (CC BY 3.0)
Datum i vrijeme pohrane2018-11-27 17:36:31