INTRODUCTION: Quantitative disorders of consciousness can be caused by a pathology of the central nervous sistem (CNS) or systemic disturbance. After the inital impact to the CNS that has led to altered consciousness, the patient usually passes through different stages in the recovery phase. However, there is no „gold standard“ to asses the level of quantitative disorder of consciousness and several different types of neurological examination and neurobihevioral scales are used in everyday practice. AIM: Assessment of diagnostic sensitivity and specificity of four neurobihevioral scales in patients with pathology of the CNS. MATERIALS AND METHODS: The study included 30 patients with pathology of the CNS treated in the intensive care unit at the Department of Anesthesiology and Intensive Care and Department of Neurology. Patients were evaluated with neurobihevioral scales on the day of admission, 2 and 12 days after the termination of the analgosedation. RESULTS: Of the four neurobihevioral scales we applied, the statistical significance was obtained at GCS between the admission and the 1st assessment of the overall result, the verbal and motor response, and on the FOUR between the admission and the 1st assessment as well as between admission and the 2nd assessment on the overall result, the motor response, brain stem reflexes and breathing. GOS and CRS-R did not show any statistical significance. DISCUSSION AND CONCLUSION: In the field of intensive care, FOUR proved to be superior to GCS, GOS and CRS-R scales