Sepsis is a syndrome which has a constant incidence rise, and it entailes a collection of symptoms which arise as the body's response to sistemic inflammation. The main clinical signs of sepsis are a rise or fall in body temperature, altered state of consciousness, increased heart and respiration rates. With more severe forms of the septic process, these symptoms can be accompanied by signs of multiple organ failure, and a fall in blood pressure as a sign of shock. Because this is a condition with a high mortality rate, it is extremely important to recognize it and treat it quickly. When diagnosing the gravity of sepsis, we can help ourselves by testing the levels of C reactive protein, an acute phase reactant which indicates an active state of the inflammatory process, the levels od procalcitonin, which can indicate a bacterial or fungal infection, and the levels of lactates, which indicate a more severe progression of the septic process, including the development of septic shock. The purpose of this thesis was to explore the connection between C reactive protein, lactates and procalcitonin and the type of outcome in treating patients with sepsis. The analyzed data was taken from 155 patients who were hospitalized in the Intensive care units of Clinical hospital centre Rijeka during the year 2017. The following sets of data were collected: gender, age, microbiological findings, cause of sepsis, the most unfavorable values of CRP, procalcitonin and lactates, antibiotic therapy, duration of hospitalization and outcome. The statistic analysis showed a positive statistic connection of higher values of lactates with a less favorable outcome, while the correlation was lacking for CRP and procalcitonin. The obtained results are in line with other research conducted on thistopic, which have shown the connection of high levels of lactates with more grave forms of sepsis and the development of septic shock and a higher mortality as a direct consequence.