prikaz prve stranice dokumenta Cytomegalovirus microRNAs Facilitate Persistent Virus Infection in Salivary Glands
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Cytomegalovirus microRNAs Facilitate Persistent Virus Infection in Salivary Glands
PLoS Pathogens, 6 (2010), 10; e1001150. https://doi.org/10.1371/journal.ppat.1001150
Dölken, Lars; Krmpotić, Astrid; Kothe, Sheila; Tuddenham, Lee; Tanguy, Mélanie; Marcinowski, Lisa; Ruzsics, Zsolt; Elefant, Naama; Altuvia, Yael; Margalit, Hanah; Koszinowski, Ulrich H.; Jonjić, Stipan; Pfeffer, Sébastien

Citirajte ovaj rad

Dölken, L., Krmpotić, A., Kothe, S., Tuddenham, L., Tanguy, M., Marcinowski, L. ... Pfeffer, S. (2010). Cytomegalovirus microRNAs Facilitate Persistent Virus Infection in Salivary Glands. PLoS Pathogens, 6. (10). doi: 10.1371/journal.ppat.1001150

Dölken, Lars, et al. "Cytomegalovirus microRNAs Facilitate Persistent Virus Infection in Salivary Glands." PLoS Pathogens, vol. 6, br. 10, 2010. https://doi.org/10.1371/journal.ppat.1001150

Dölken, Lars, Astrid Krmpotić, Sheila Kothe, Lee Tuddenham, Mélanie Tanguy, Lisa Marcinowski, Zsolt Ruzsics, et al. "Cytomegalovirus microRNAs Facilitate Persistent Virus Infection in Salivary Glands." PLoS Pathogens 6, br. 10 (2010). https://doi.org/10.1371/journal.ppat.1001150

Dölken, L., et al. (2010) 'Cytomegalovirus microRNAs Facilitate Persistent Virus Infection in Salivary Glands', PLoS Pathogens, 6(10). doi: 10.1371/journal.ppat.1001150

Dölken L, Krmpotić A, Kothe S, Tuddenham L, Tanguy M, Marcinowski L, i sur.. Cytomegalovirus microRNAs Facilitate Persistent Virus Infection in Salivary Glands. PLoS Pathogens [Internet]. 14.10.2010. [pristupljeno 05.12.2024.];6(10). doi: 10.1371/journal.ppat.1001150

L. Dölken, et al., "Cytomegalovirus microRNAs Facilitate Persistent Virus Infection in Salivary Glands", PLoS Pathogens, vol. 6, br. 10, Listopad 2010. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:298322. [Citirano: 05.12.2024.]

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Naslov (engleski)Cytomegalovirus microRNAs Facilitate Persistent Virus Infection in Salivary Glands
AutorLars Dölken
AutorAstrid Krmpotić
AutorSheila Kothe
AutorLee Tuddenham
AutorMélanie Tanguy
AutorLisa Marcinowski
AutorZsolt Ruzsics
AutorNaama Elefant
AutorYael Altuvia
AutorHanah Margalit
AutorUlrich H. Koszinowski
AutorStipan Jonjić
AutorSébastien Pfeffer
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Micro (mi)RNAs are small non-coding RNAs that regulate the expression of their targets' messenger RNAs through both translational inhibition and regulation of target RNA stability. Recently, a number of viruses, particularly of the herpesvirus family, have been shown to express their own miRNAs to control both viral and cellular transcripts. Although some targets of viral miRNAs are known, their function in a physiologically relevant infection remains to be elucidated. As such, no in vivo phenotype of a viral miRNA knock-out mutant has been described so far. Here, we report on the first functional phenotype of a miRNA knock-out virus in vivo. During subacute infection of a mutant mouse cytomegalovirus lacking two viral miRNAs, virus production is selectively reduced in salivary glands, an organ essential for virus persistence and horizontal transmission. This phenotype depends on several parameters including viral load and mouse genetic background, and is abolished by combined but not single depletion of natural killer (NK) and CD4+ T cells. Together, our results point towards a miRNA-based immunoevasion mechanism important for long-term virus persistence.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPLoS Pathogens
Brojčani podacivol. 6, br. 10, e1001150
e-ISSN1553-7374
DOIhttps://doi.org/10.1371/journal.ppat.1001150
URN:NBNurn:nbn:hr:184:298322
Datum objave publikacije2010-10-14
ProjektŠifra: 062-0621261-1263
Naziv (hrvatski): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
ProjektŠifra: 062-0621261-1268
Naziv (hrvatski): Uloga imunosubverzivnih citomegalovirusnih gena u latenciji
Voditelj: Astrid Krmpotić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttps://dx.plos.org/10.1371/journal.ppat.1001150
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-11-08 23:09:24