prikaz prve stranice dokumenta Differential Susceptibility of RAE-1 Isoforms to Mouse Cytomegalovirus
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Differential Susceptibility of RAE-1 Isoforms to Mouse Cytomegalovirus
Journal of Virology, 83 (2009), 16; 8198-8207. https://doi.org/10.1128/JVI.02549-08
Arapović, Jurica; Lenac, Tihana; Antulov, Ronald; Polić, Bojan; Ruzsics, Z.; Carayannopoulos, L. N.; Koszinowski, U. H.; Krmpotić, Astrid; Jonjić, Stipan

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Arapović, J., Lenac, T., Antulov, R., Polić, B., Ruzsics, Z., Carayannopoulos, L. N. ... Jonjić, S. (2009). Differential Susceptibility of RAE-1 Isoforms to Mouse Cytomegalovirus. Journal of Virology, 83. (16), 8198-8207. doi: 10.1128/JVI.02549-08

Arapović, Jurica, et al. "Differential Susceptibility of RAE-1 Isoforms to Mouse Cytomegalovirus." Journal of Virology, vol. 83, br. 16, 2009, str. 8198-8207. https://doi.org/10.1128/JVI.02549-08

Arapović, Jurica, Tihana Lenac, Ronald Antulov, Bojan Polić, Z. Ruzsics, L. N. Carayannopoulos, U. H. Koszinowski, Astrid Krmpotić i Stipan Jonjić. "Differential Susceptibility of RAE-1 Isoforms to Mouse Cytomegalovirus." Journal of Virology 83, br. 16 (2009): 8198-8207. https://doi.org/10.1128/JVI.02549-08

Arapović, J., et al. (2009) 'Differential Susceptibility of RAE-1 Isoforms to Mouse Cytomegalovirus', Journal of Virology, 83(16), str. 8198-8207. doi: 10.1128/JVI.02549-08

Arapović J, Lenac T, Antulov R, Polić B, Ruzsics Z, Carayannopoulos LN, i sur.. Differential Susceptibility of RAE-1 Isoforms to Mouse Cytomegalovirus. Journal of Virology [Internet]. 03.06.2009. [pristupljeno 14.11.2024.];83(16):8198-8207. doi: 10.1128/JVI.02549-08

J. Arapović, et al., "Differential Susceptibility of RAE-1 Isoforms to Mouse Cytomegalovirus", Journal of Virology, vol. 83, br. 16, str. 8198-8207, Lipanj 2009. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:478936. [Citirano: 14.11.2024.]

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Naslov (engleski)Differential Susceptibility of RAE-1 Isoforms to Mouse Cytomegalovirus
AutorJurica Arapović
AutorTihana Lenac
AutorRonald Antulov
AutorBojan Polić
AutorZ. Ruzsics
AutorL. N. Carayannopoulos
AutorU. H. Koszinowski
AutorAstrid Krmpotić
AutorStipan Jonjić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
The NKG2D receptor is one of the most potent activating natural killer cell receptors involved in antiviral responses. The mouse NKG2D ligands MULT-1, RAE-1, and H60 are regulated by murine cytomegalovirus (MCMV) proteins m145, m152, and m155, respectively. In addition, the m138 protein interferes with the expression of both MULT-1 and H60. We show here that one of five RAE-1 isoforms, RAE-1, is resistant to downregulation by MCMV and that this escape has functional importance in vivo. Although m152 retained newly synthesized RAE-1 and RAE-1 in the endoplasmic reticulum, no viral regulator was able to affect the mature RAE-1 form which remains expressed on the surfaces of infected cells. This differential susceptibility to downregulation by MCMV is not a consequence of faster maturation of RAE-1 compared to RAE-1 but rather an intrinsic property of the mature surface-resident protein. This difference can be attributed to the absence of a PLWY motif from RAE-1. Altogether, these findings provide evidence for a novel mechanism of host escape from viral immunoevasion of NKG2D-dependent control.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Virology
Brojčani podacivol. 83, br. 16, str. 8198-8207
p-ISSN0022-538X
DOIhttps://doi.org/10.1128/JVI.02549-08
URN:NBNurn:nbn:hr:184:478936
Datum objave publikacije2009-06-03
Datum objave publikacije2009-08-15
URL dokumentahttp://jvi.asm.org/cgi/doi/10.1128/JVI.02549-08
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-11-08 22:28:08