prikaz prve stranice dokumenta Pro-Apoptotic Protein Noxa Regulates Memory T Cell Population Size and Protects against Lethal Immunopathology
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Pro-Apoptotic Protein Noxa Regulates Memory T Cell Population Size and Protects against Lethal Immunopathology
The Journal of Immunology, 190 (2012), 3; 1180-1191. https://doi.org/10.4049/jimmunol.1202304
Wensveen, F. M.; Klarenbeek, P. L.; van Gisbergen, K. P. J. M.; Pascutti, M. F.; Derks, I. A. M.; van Schaik, B. D. C.; ten Brinke, A.; de Vries, N.; Cekinović, Đurđica; Jonjić, Stipan; van Lier, R. A. W.; Eldering, E.

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Wensveen, F. M., Klarenbeek, P. L., van Gisbergen, K. P. J. M., Pascutti, M. F., Derks, I. A. M., van Schaik, B. D. C. ... Eldering, E. (2012). Pro-Apoptotic Protein Noxa Regulates Memory T Cell Population Size and Protects against Lethal Immunopathology. The Journal of Immunology, 190. (3), 1180-1191. doi: 10.4049/jimmunol.1202304

Wensveen, F. M., et al. "Pro-Apoptotic Protein Noxa Regulates Memory T Cell Population Size and Protects against Lethal Immunopathology." The Journal of Immunology, vol. 190, br. 3, 2012, str. 1180-1191. https://doi.org/10.4049/jimmunol.1202304

Wensveen, F. M., P. L. Klarenbeek, K. P. J. M. van Gisbergen, M. F. Pascutti, I. A. M. Derks, B. D. C. van Schaik, A. ten Brinke, et al. "Pro-Apoptotic Protein Noxa Regulates Memory T Cell Population Size and Protects against Lethal Immunopathology." The Journal of Immunology 190, br. 3 (2012): 1180-1191. https://doi.org/10.4049/jimmunol.1202304

Wensveen, F. M., et al. (2012) 'Pro-Apoptotic Protein Noxa Regulates Memory T Cell Population Size and Protects against Lethal Immunopathology', The Journal of Immunology, 190(3), str. 1180-1191. doi: 10.4049/jimmunol.1202304

Wensveen FM, Klarenbeek PL, van Gisbergen KPJM, Pascutti MF, Derks IAM, van Schaik BDC, i sur.. Pro-Apoptotic Protein Noxa Regulates Memory T Cell Population Size and Protects against Lethal Immunopathology. The Journal of Immunology [Internet]. 31.12.2012. [pristupljeno 13.11.2024.];190(3):1180-1191. doi: 10.4049/jimmunol.1202304

F. M. Wensveen, et al., "Pro-Apoptotic Protein Noxa Regulates Memory T Cell Population Size and Protects against Lethal Immunopathology", The Journal of Immunology, vol. 190, br. 3, str. 1180-1191, Prosinac 2012. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:924563. [Citirano: 13.11.2024.]

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Naslov (engleski)Pro-Apoptotic Protein Noxa Regulates Memory T Cell Population Size and Protects against Lethal Immunopathology
AutorF. M. Wensveen
AutorP. L. Klarenbeek
AutorK. P. J. M. van Gisbergen
AutorM. F. Pascutti
AutorI. A. M. Derks
AutorB. D. C. van Schaik
AutorA. ten Brinke
AutorN. de Vries
AutorĐurđica Cekinović
AutorStipan Jonjić
AutorR. A. W. van Lier
AutorE. Eldering
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Memory T cells form a highly specific defense layer against reinfection with previously encountered pathogens. In addition, memory T cells provide protection against pathogens that are similar, but not identical to the original infectious agent. This is because each T cell response harbors multiple clones with slightly different affinities, thereby creating T cell memory with a certain degree of diversity. Currently, the mechanisms that control size, diversity, and cross-reactivity of the memory T cell pool are incompletely defined. Previously, we established a role for apoptosis, mediated by the BH3-only protein Noxa, in controlling diversity of the effector T cell population. This function might positively or negatively impact T cell memory in terms of function, pool size, and cross-reactivity during recall responses. Therefore, we investigated the role of Noxa in T cell memory during acute and chronic infections. Upon influenza infection, Noxa−/− mice generate a memory compartment of increased size and clonal diversity. Reinfection resulted in an increased recall response, whereas cross-reactive responses were impaired. Chronic infection of Noxa−/− mice with mouse CMV resulted in enhanced memory cell inflation, but no obvious pathology. In contrast, in a model of continuous, high-level T cell activation, reduced apoptosis of activated T cells rapidly led to severe organ pathology and premature death in Noxa-deficient mice. These results establish Noxa as an important regulator of the number of memory cells formed during infection. Chronic immune activation in the absence of Noxa leads to excessive accumulation of primed cells, which may result in severe pathology.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaThe Journal of Immunology
Brojčani podacivol. 190, br. 3, str. 1180-1191
p-ISSN0022-1767
e-ISSN1550-6606
DOIhttps://doi.org/10.4049/jimmunol.1202304
URN:NBNurn:nbn:hr:184:924563
Datum objave publikacije2012-12-31
Datum objave publikacije2013-02-01
URL dokumentahttp://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1202304
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-11-08 14:26:05