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The NK Cell Response to Mouse Cytomegalovirus Infection Affects the Level and Kinetics of the Early CD8+ T-Cell Response
Journal of Virology, 86 (2012), 4; 2165-2175. https://doi.org/10.1128/JVI.06042-11
Mitrović, Maja; Arapović, Jurica; Jordan, Stefan; Fodil-Cornu, N.; Ebert, S.; Vidal, S. M.; Krmpotić, Astrid; Reddehase, M. J.; Jonjić, Stipan

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Mitrović, M., Arapović, J., Jordan, S., Fodil Cornu, N., Ebert, S., Vidal, S. M. ... Jonjić, S. (2012). The NK Cell Response to Mouse Cytomegalovirus Infection Affects the Level and Kinetics of the Early CD8+ T-Cell Response. Journal of Virology, 86. (4), 2165-2175. doi: 10.1128/JVI.06042-11

Mitrović, Maja, et al. "The NK Cell Response to Mouse Cytomegalovirus Infection Affects the Level and Kinetics of the Early CD8+ T-Cell Response." Journal of Virology, vol. 86, br. 4, 2012, str. 2165-2175. https://doi.org/10.1128/JVI.06042-11

Mitrović, Maja, Jurica Arapović, Stefan Jordan, N. Fodil Cornu, S. Ebert, S. M. Vidal, Astrid Krmpotić, M. J. Reddehase i Stipan Jonjić. "The NK Cell Response to Mouse Cytomegalovirus Infection Affects the Level and Kinetics of the Early CD8+ T-Cell Response." Journal of Virology 86, br. 4 (2012): 2165-2175. https://doi.org/10.1128/JVI.06042-11

Mitrović, M., et al. (2012) 'The NK Cell Response to Mouse Cytomegalovirus Infection Affects the Level and Kinetics of the Early CD8+ T-Cell Response', Journal of Virology, 86(4), str. 2165-2175. doi: 10.1128/JVI.06042-11

Mitrović M, Arapović J, Jordan S, Fodil Cornu N, Ebert S, Vidal SM, i sur.. The NK Cell Response to Mouse Cytomegalovirus Infection Affects the Level and Kinetics of the Early CD8+ T-Cell Response. Journal of Virology [Internet]. 07.12.2012. [pristupljeno 21.10.2024.];86(4):2165-2175. doi: 10.1128/JVI.06042-11

M. Mitrović, et al., "The NK Cell Response to Mouse Cytomegalovirus Infection Affects the Level and Kinetics of the Early CD8+ T-Cell Response", Journal of Virology, vol. 86, br. 4, str. 2165-2175, Prosinac 2012. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:713679. [Citirano: 21.10.2024.]

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Naslov (engleski)The NK Cell Response to Mouse Cytomegalovirus Infection Affects the Level and Kinetics of the Early CD8+ T-Cell Response
AutorMaja Mitrović
AutorJurica Arapović
AutorStefan Jordan
AutorN. Fodil-Cornu
AutorS. Ebert
AutorS. M. Vidal
AutorAstrid Krmpotić
AutorM. J. Reddehase
AutorStipan Jonjić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Natural killer (NK) cells and CD8+ T cells play a prominent role in the clearance of mouse cytomegalovirus (MCMV) infection. The role of NK cells in modulating the CD8+ T-cell response to MCMV infection is still the subject of intensive research. For analyzing the impact of NK cells on mounting of a CD8+ T-cell response and the contribution of these cells to virus control during the first days postinfection (p.i.), we used C57BL/6 mice in which NK cells are specifically activated through the Ly49H receptor engaged by the MCMV-encoded ligand m157. Our results indicate that the requirement for CD8+ T cells in early MCMV control inversely correlates with the engagement of Ly49H. While depletion of CD8+ T cells has only a minor effect on the early control of wild-type MCMV, CD8+ T cells are essential in the control of Δm157 virus. The frequencies of virus epitope-specific CD8+ T cells and their activation status were higher in mice infected with Δm157 virus. In addition, these mice showed elevated levels of alpha interferon (IFN-α) and several other proinflammatory cytokines as early as 1.5 days p.i. Although the numbers of conventional dendritic cells (cDCs) were reduced later during infection, particularly in Δm157-infected mice, they were not significantly affected at the peak of the cytokine response. Altogether, we concluded that increased antigen load, preservation of early cDCs' function, and higher levels of innate cytokines collectively account for an enhanced CD8+ T-cell response in C57BL/6 mice infected with a virus unable to activate NK cells via the Ly49H–m157 interaction.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Virology
Brojčani podacivol. 86, br. 4, str. 2165-2175
p-ISSN0022-538X
DOIhttps://doi.org/10.1128/JVI.06042-11
URN:NBNurn:nbn:hr:184:713679
Datum objave publikacije2012-12-07
Datum objave publikacije2012-02-15
ProjektŠifra: 062-0621261-1263
Naziv (hrvatski): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
ProjektŠifra: 062-0621261-1268
Naziv (hrvatski): Uloga imunosubverzivnih citomegalovirusnih gena u latenciji
Voditelj: Astrid Krmpotić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttp://jvi.asm.org/cgi/doi/10.1128/JVI.06042-11
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-11-08 11:14:53