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NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development
Nature Immunology, 19 (2018), 10; 1083-1092. https://doi.org/10.1038/s41590-018-0209-9
Jelenčić, Vedrana; Šestan, Marko; Kavazović, Inga; Lenartić, Maja; Marinović, Sonja; Holmes, Tim D.; Prchal-Murphy, Michaela; Lisnić, Berislav; Sexl, Veronika; Bryceson, Yenan T.; Wensveen, Felix M.; Polić, Bojan

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Jelenčić, V., Šestan, M., Kavazović, I., Lenartić, M., Marinović, S., Holmes, T. D. ... Polić, B. (2018). NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development. Nature Immunology, 19. (10), 1083-1092. doi: 10.1038/s41590-018-0209-9

Jelenčić, Vedrana, et al. "NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development." Nature Immunology, vol. 19, br. 10, 2018, str. 1083-1092. https://doi.org/10.1038/s41590-018-0209-9

Jelenčić, Vedrana, Marko Šestan, Inga Kavazović, Maja Lenartić, Sonja Marinović, Tim D. Holmes, Michaela Prchal Murphy, et al. "NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development." Nature Immunology 19, br. 10 (2018): 1083-1092. https://doi.org/10.1038/s41590-018-0209-9

Jelenčić, V., et al. (2018) 'NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development', Nature Immunology, 19(10), str. 1083-1092. doi: 10.1038/s41590-018-0209-9

Jelenčić V, Šestan M, Kavazović I, Lenartić M, Marinović S, Holmes TD, i sur.. NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development. Nature Immunology [Internet]. 17.09.2018. [pristupljeno 25.04.2024.];19(10):1083-1092. doi: 10.1038/s41590-018-0209-9

V. Jelenčić, et al., "NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development", Nature Immunology, vol. 19, br. 10, str. 1083-1092, Rujan 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:508103. [Citirano: 25.04.2024.]

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Naslov (engleski)NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development
AutorVedrana Jelenčić
AutorMarko Šestan
AutorInga Kavazović
AutorMaja Lenartić
AutorSonja Marinović
AutorTim D. Holmes
AutorMichaela Prchal-Murphy
AutorBerislav Lisnić
AutorVeronika Sexl
AutorYenan T. Bryceson https://orcid.org/0000-0002-7783-9934
AutorFelix M. Wensveen
AutorBojan Polić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
The activation of natural killer (NK) cells depends on a change in the balance of signals from inhibitory and activating receptors. The activation threshold values of NK cells are thought to be set by engagement of inhibitory receptors during development. Here, we found that the activating receptor NKG2D specifically set the activation threshold for the activating receptor NCR1 through a process that required the adaptor DAP12. As a result, NKGD2-deficient (Klrk1-/-) mice controlled tumors and cytomegalovirus infection better than wild-type controls through the NCR1-induced production of the cytokine IFN-γ. Expression of NKG2D before the immature NK cell stage increased expression of the adaptor CD3ζ. Reduced expression of CD3ζ in Klrk1-/- mice was associated with enhanced signal transduction through NCR1, and CD3ζ deficiency resulted in hyper-responsiveness to stimulation via NCR1. Thus, an activating receptor developmentally set the activity of another activating receptor on NK cells and determined NK cell reactivity to cellular threats.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNature Immunology
Brojčani podacivol. 19, br. 10, str. 1083-1092
p-ISSN1529-2908
e-ISSN1529-2916
DOIhttps://doi.org/10.1038/s41590-018-0209-9
URN:NBNurn:nbn:hr:184:508103
Datum objave publikacije2018-09-17
Datum objave publikacije2018-10
ProjektŠifra: 311335
Naziv (hrvatski): Next generation sequencing for detection of human primary immunodeficiency syndromes characterized by impaired cytotoxic lymphocyte function
Kratica: SEQ-CYTOTOX
Pravna nadležnost: eu
Financijer: EC
Financijer: EC
Linija financiranja: FP7
ProjektŠifra: IP-2016-06-9306
Naziv (hrvatski): Imunosni mehanizmi u razvoju upale i metaboličkog sindroma u debljini
Kratica: INFLAMETAB
Voditelj: Bojan Polić
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Financijer: HRZZ
Linija financiranja: IP
URL dokumentahttp://www.nature.com/articles/s41590-018-0209-9
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Datum isteka embarga: 2019-03-17
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-11-05 10:31:00