prikaz prve stranice dokumenta Cutting Edge: NKG2D Signaling Enhances NK Cell Responses but Alone Is Insufficient To Drive Expansion during Mouse Cytomegalovirus Infection
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Cutting Edge: NKG2D Signaling Enhances NK Cell Responses but Alone Is Insufficient To Drive Expansion during Mouse Cytomegalovirus Infection
The Journal of Immunology, 199 (2017), 5; 1567-1571. https://doi.org/10.4049/jimmunol.1700799
Nabekura, Tsukasa; Gotthardt, Dagmar; Niizuma, Kouta; Tršan, Tihana; Jenuš, Tina; Jonjić, Stipan; Lanier, Lewis L.

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Nabekura, T., Gotthardt, D., Niizuma, K., Tršan, T., Jenuš, T., Jonjić, S. i Lanier, L. L. (2017). Cutting Edge: NKG2D Signaling Enhances NK Cell Responses but Alone Is Insufficient To Drive Expansion during Mouse Cytomegalovirus Infection. The Journal of Immunology, 199. (5), 1567-1571. doi: 10.4049/jimmunol.1700799

Nabekura, Tsukasa, et al. "Cutting Edge: NKG2D Signaling Enhances NK Cell Responses but Alone Is Insufficient To Drive Expansion during Mouse Cytomegalovirus Infection." The Journal of Immunology, vol. 199, br. 5, 2017, str. 1567-1571. https://doi.org/10.4049/jimmunol.1700799

Nabekura, Tsukasa, Dagmar Gotthardt, Kouta Niizuma, Tihana Tršan, Tina Jenuš, Stipan Jonjić i Lewis L. Lanier. "Cutting Edge: NKG2D Signaling Enhances NK Cell Responses but Alone Is Insufficient To Drive Expansion during Mouse Cytomegalovirus Infection." The Journal of Immunology 199, br. 5 (2017): 1567-1571. https://doi.org/10.4049/jimmunol.1700799

Nabekura, T., et al. (2017) 'Cutting Edge: NKG2D Signaling Enhances NK Cell Responses but Alone Is Insufficient To Drive Expansion during Mouse Cytomegalovirus Infection', The Journal of Immunology, 199(5), str. 1567-1571. doi: 10.4049/jimmunol.1700799

Nabekura T, Gotthardt D, Niizuma K, Tršan T, Jenuš T, Jonjić S, i sur.. Cutting Edge: NKG2D Signaling Enhances NK Cell Responses but Alone Is Insufficient To Drive Expansion during Mouse Cytomegalovirus Infection. The Journal of Immunology [Internet]. 01.09.2017. [pristupljeno 24.12.2024.];199(5):1567-1571. doi: 10.4049/jimmunol.1700799

T. Nabekura, et al., "Cutting Edge: NKG2D Signaling Enhances NK Cell Responses but Alone Is Insufficient To Drive Expansion during Mouse Cytomegalovirus Infection", The Journal of Immunology, vol. 199, br. 5, str. 1567-1571, Rujan 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:981243. [Citirano: 24.12.2024.]

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Naslov (engleski)Cutting Edge: NKG2D Signaling Enhances NK Cell Responses but Alone Is Insufficient To Drive Expansion during Mouse Cytomegalovirus Infection
AutorTsukasa Nabekura
AutorDagmar Gotthardt
AutorKouta Niizuma
AutorTihana Tršan
AutorTina Jenuš
AutorStipan Jonjić
AutorLewis L. Lanier
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
NK cells play a critical role in host defense against viruses. In this study, we investigated the role of NKG2D in the expansion of NK cells after mouse CMV (MCMV) infection. Wild-type and NKG2D-deficient (Klrk1−/−) Ly49H+ NK cells proliferated robustly when infected with MCMV strains engineered to allow expression of NKG2D ligands, which enhanced the response of wild-type NK cells. Naive NK cells exclusively express NKG2D-L, which pairs only with DAP10, whereas NKG2D-S expressed by activated NK cells pairs with DAP10 and DAP12, similar to Ly49H. However, NKG2D alone was unable to drive robust expansion of Ly49H− NK cells when mice were infected with these MCMV strains, likely because NKG2D-S was only transiently expressed postinfection. These findings demonstrate that NKG2D augments Ly49H-dependent proliferation of NK cells; however, NKG2D signaling alone is inadequate for expansion of NK cells, likely due to only transient expression of the NKG2D–DAP12 complex.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaThe Journal of Immunology
Brojčani podacivol. 199, br. 5, str. 1567-1571
p-ISSN0022-1767
e-ISSN1550-6606
DOIhttps://doi.org/10.4049/jimmunol.1700799
URN:NBNurn:nbn:hr:184:981243
Datum objave publikacije2017-09-01
Datum objave publikacije2017-07-31
ProjektŠifra: 322693
Naziv (hrvatski): Strengthening adaptive immunity via innate immunity: enhancing the CD8 T cell response by using the NKG2D ligand expressed in a herpesvirus vector
Kratica: STADVINN
Pravna nadležnost: eu
Financijer: EC
Linija financiranja: FP7
ProjektŠifra: 062-0621261-1263
Naziv (hrvatski): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttp://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1700799
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-10-30 20:45:26