prikaz prve stranice dokumenta Diagnostic significance of immunoglobulin G avidity in symptomatic and asymptomatic West Nile virus infection
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Diagnostic significance of immunoglobulin G avidity in symptomatic and asymptomatic West Nile virus infection
Revista da Sociedade Brasileira de Medicina Tropical, 51 (2018), 5; 591-595. https://doi.org/10.1590/0037-8682-0482-2017
Vilibić-Čavlek, Tatjana; Kristofić, Branimir; Savić, Vladimir; Kolarić, Branko; Barbić, Ljubo; Tabain, Irena; Perić, Ljiljana; Sabadi, Dario; Miklaušić, Bozana; Potočnik-Hunjadi, Tanja; Zember, Sanja; Stevanović, Vladimir; Listes, Eddy; Savini, Giovanni

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Vilibić Čavlek, T., Kristofić, B., Savić, V., Kolarić, B., Barbić, Lj., Tabain, I. ... Savini, G. (2018). Diagnostic significance of immunoglobulin G avidity in symptomatic and asymptomatic West Nile virus infection. Revista da Sociedade Brasileira de Medicina Tropical, 51. (5), 591-595. doi: 10.1590/0037-8682-0482-2017

Vilibić Čavlek, Tatjana, et al. "Diagnostic significance of immunoglobulin G avidity in symptomatic and asymptomatic West Nile virus infection." Revista da Sociedade Brasileira de Medicina Tropical, vol. 51, br. 5, 2018, str. 591-595. https://doi.org/10.1590/0037-8682-0482-2017

Vilibić Čavlek, Tatjana, Branimir Kristofić, Vladimir Savić, Branko Kolarić, Ljubo Barbić, Irena Tabain, Ljiljana Perić, et al. "Diagnostic significance of immunoglobulin G avidity in symptomatic and asymptomatic West Nile virus infection." Revista da Sociedade Brasileira de Medicina Tropical 51, br. 5 (2018): 591-595. https://doi.org/10.1590/0037-8682-0482-2017

Vilibić Čavlek, T., et al. (2018) 'Diagnostic significance of immunoglobulin G avidity in symptomatic and asymptomatic West Nile virus infection', Revista da Sociedade Brasileira de Medicina Tropical, 51(5), str. 591-595. doi: 10.1590/0037-8682-0482-2017

Vilibić Čavlek T, Kristofić B, Savić V, Kolarić B, Barbić Lj, Tabain I, i sur.. Diagnostic significance of immunoglobulin G avidity in symptomatic and asymptomatic West Nile virus infection. Revista da Sociedade Brasileira de Medicina Tropical [Internet]. 10.2018. [pristupljeno 25.12.2024.];51(5):591-595. doi: 10.1590/0037-8682-0482-2017

T. Vilibić Čavlek, et al., "Diagnostic significance of immunoglobulin G avidity in symptomatic and asymptomatic West Nile virus infection", Revista da Sociedade Brasileira de Medicina Tropical, vol. 51, br. 5, str. 591-595, Listopad 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:145899. [Citirano: 25.12.2024.]

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Naslov (engleski)Diagnostic significance of immunoglobulin G avidity in symptomatic and asymptomatic West Nile virus infection
AutorTatjana Vilibić-Čavlek
AutorBranimir Kristofić
AutorVladimir Savić
AutorBranko Kolarić
AutorLjubo Barbić
AutorIrena Tabain
AutorLjiljana Perić
AutorDario Sabadi
AutorBozana Miklaušić
AutorTanja Potočnik-Hunjadi
AutorSanja Zember
AutorVladimir Stevanović
AutorEddy Listes
AutorGiovanni Savini
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za socijalnu medicinu i epidemiologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Javno zdravstvo i zdravstvena zaštita
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Infektologija
Sažetak (engleski)
INTRODUCTION: West Nile virus (WNV) immunoglobulin M (IgM) antibodies have been shown to persist for up to 500 days in certain patients. To evaluate the usefulness of immunoglobulin G (IgG) avidity assessment in the diagnosis of WNV infection, we analyzed 54 WNV IgM- and/or IgG-positive serum samples from 39 patients with neuroinvasive disease and 15 asymptomatic cases tested during a seroprevalence investigation. METHODS: Serological tests (WNV IgM/IgG antibody detection, IgG avidity) were performed using commercially available enzyme-linked immunosorbent assays. RESULTS: WNV IgM antibodies were detected in 47 (87%) samples. Acute/recent WNV infection was confirmed based on low/borderline avidity index (AI) in 44 IgM-positive samples (93.6%). In three IgM-positive samples (6.4%), high IgG AIs were detected, thus indicating persisting IgM antibodies from previous infections. All IgM-negative samples showed high AIs. Patients with WNV neuroinvasive disease tested within 30 days showed low AIs. In six patients tested 34-50 days after disease onset, AI was borderline (42%-60%), suggesting earlier WNV IgG maturation. Samples with the highest IgM values were associated with the lowest AIs (Spearman's rho coefficient -0.767, p < 0.001). CONCLUSIONS: Our results indicate that IgG avidity differentiates current/recent WNV infection from persistent IgM seropositivity from the previous WNV transmission season both in patients with WNV neuroinvasive disease and in asymptomatic persons. A strong negative correlation between IgM antibody levels and AI indicates that in cases with very high IgM levels, determination of IgG avidity may not be necessary. As many patients showed rapid avidity maturation, low IgG avidity is indicative of WNV infection within the previous month.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaRevista da Sociedade Brasileira de Medicina Tropical
Brojčani podacivol. 51, br. 5, str. 591-595
p-ISSN0037-8682
e-ISSN1678-9849
DOIhttps://doi.org/10.1590/0037-8682-0482-2017
URN:NBNurn:nbn:hr:184:145899
Datum objave publikacije2018-10
ProjektŠifra: IP-2016-06-7456
Naziv (hrvatski): Prevalencija i molekularna epidemiologija emergentnih i re-emergentnih neuroinvazivnih arbovirusnih infekcija na području Hrvatske
Kratica: CRONEUROARBO
Voditelj: Tatjana Vilibić Čavlek
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
URL dokumentahttp://www.scielo.br/pdf/rsbmt/v51n5/1678-9849-rsbmt-51-05-591.pdf
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-10-30 11:15:22