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Postoperative Regional Analgesia Is Effective in Preserving Perforin-Expressing Lymphocytes in Patients After Total Knee Replacement
Medical Science Monitor, 24 (2018); 5320-5328. https://doi.org/10.12659/MSM.909385
Velčić Brumnjak, Sandra; Rakovac, Ivan; Papež Kinkela, Dijana; Bukal, Krešimir; Šestan, Branko; Tulić, Vera; Velčić Janjetic, Elisa; Sotošek Tokmadžić, Vlatka

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Velčić Brumnjak, S., Rakovac, I., Papež Kinkela, D., Bukal, K., Šestan, B., Tulić, V. ... Sotošek Tokmadžić, V. (2018). Postoperative Regional Analgesia Is Effective in Preserving Perforin-Expressing Lymphocytes in Patients After Total Knee Replacement. Medical Science Monitor, 24., 5320-5328. doi: 10.12659/MSM.909385

Velčić Brumnjak, Sandra, et al. "Postoperative Regional Analgesia Is Effective in Preserving Perforin-Expressing Lymphocytes in Patients After Total Knee Replacement." Medical Science Monitor, vol. 24, 2018, str. 5320-5328. https://doi.org/10.12659/MSM.909385

Velčić Brumnjak, Sandra, Ivan Rakovac, Dijana Papež Kinkela, Krešimir Bukal, Branko Šestan, Vera Tulić, Elisa Velčić Janjetic i Vlatka Sotošek Tokmadžić. "Postoperative Regional Analgesia Is Effective in Preserving Perforin-Expressing Lymphocytes in Patients After Total Knee Replacement." Medical Science Monitor 24 (2018): 5320-5328. https://doi.org/10.12659/MSM.909385

Velčić Brumnjak, S., et al. (2018) 'Postoperative Regional Analgesia Is Effective in Preserving Perforin-Expressing Lymphocytes in Patients After Total Knee Replacement', Medical Science Monitor, 24, str. 5320-5328. doi: 10.12659/MSM.909385

Velčić Brumnjak S, Rakovac I, Papež Kinkela D, Bukal K, Šestan B, Tulić V, i sur.. Postoperative Regional Analgesia Is Effective in Preserving Perforin-Expressing Lymphocytes in Patients After Total Knee Replacement. Medical Science Monitor [Internet]. 2018. [pristupljeno 06.12.2024.];24:5320-5328. doi: 10.12659/MSM.909385

S. Velčić Brumnjak, et al., "Postoperative Regional Analgesia Is Effective in Preserving Perforin-Expressing Lymphocytes in Patients After Total Knee Replacement", Medical Science Monitor, vol. 24, str. 5320-5328, 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:864748. [Citirano: 06.12.2024.]

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Podaci o radu
Naslov (engleski)Postoperative Regional Analgesia Is Effective in Preserving Perforin-Expressing Lymphocytes in Patients After Total Knee Replacement
AutorSandra Velčić Brumnjak
AutorIvan Rakovac
AutorDijana Papež Kinkela
AutorKrešimir Bukal
AutorBranko Šestan
AutorVera Tulić
AutorElisa Velčić Janjetic
AutorVlatka Sotošek Tokmadžić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za anesteziologiju, reanimatologiju, hitnu i intenzivnu medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za ortopediju i fizikalnu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Anesteziologija i reanimatologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Ortopedija
Sažetak (engleski)
Background: Pain and surgical stress cause a pro-inflammatory response followed by downregulation of the immune response, which can increase the incidence of postoperative complications, such as infections or prolonged wound healing. T lymphocytes and natural killer (NK) cells have cytotoxic potential and are crucial components of cellular immunity, which is important for maintenance of immune balance. The aim of this study was to analyze the effects of 3 types of postoperative analgesia on the preservation and cytotoxic potential of T lymphocytes, NK cells, and their subpopulations, as well as NKT cells, in patients after total knee replacement (TKR) to find the most effective analgesic technique for mitigating immune suppression. Material/Methods: Forty-eight patients scheduled for TKR were randomly allocated to Group 1 (patients received epidural analgesia), Group 2 (patients received sciatic and femoral nerve block), or Group 3 (patients received multimodal systemic analgesia). Pain intensity was assessed at rest and on movement before, immediately after, and at 24 and 72 h after surgery. Blood samples were collected at the same time points and peripheral blood mononuclear cells were isolated. The frequencies of T lymphocytes, NK cells, and NKT cells, as well as their perforin expression, were simultaneously detected and analyzed by flow cytometry. Results: Patients in Group 1 and Group 2 experienced less severe pain than those in Group 3. The frequencies and perforin levels of T lymphocytes, their subsets, and NKT cells were significantly lower in Group 3 than in Group 1 and Group 2. Conclusions: The present study confirmed that regional analgesia is more effective in maintaining cell-mediated immunity and perforin expression in peripheral blood lymphocytes in patients after TKR.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMedical Science Monitor
Brojčani podacivol. 24, str. 5320-5328
e-ISSN1643-3750
DOIhttps://doi.org/10.12659/MSM.909385
URN:NBNurn:nbn:hr:184:864748
Datum objave publikacije2018
URL dokumentahttps://www.medscimonit.com/abstract/index/idArt/909385
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-08-06 10:50:38