prikaz prve stranice dokumenta Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis
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Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis
PLoS ONE, 13 (2018), 1; 1-7. https://doi.org/10.1371/journal.pone.0190601
Lavtar, Polona; Rudolf, Gorazd; Maver, Ales; Hodžić, Alenka; Čizmarević, Nada Starčević; Živkovic, Maja; Jazbec, Sasa Sega; Ketis, Zalika Klemenc; Kapović, Miljenko; Dinčić, Evica; Raičević, Ranko; Sepčić, Juraj; Lovrečić, Luca; Stanković, Aleksandra; Ristić, Smiljana; Peterlin, Borut Više autora...

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Lavtar, P., Rudolf, G., Maver, A., Hodžić, A., Čizmarević, N. S., Živkovic, M. ... Peterlin, B. (2018). Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis. PLoS ONE, 13. (1), 1-7. doi: 10.1371/journal.pone.0190601

Lavtar, Polona, et al. "Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis." PLoS ONE, vol. 13, br. 1, 2018, str. 1-7. https://doi.org/10.1371/journal.pone.0190601

Lavtar, Polona, Gorazd Rudolf, Ales Maver, Alenka Hodžić, Nada Starčević Čizmarević, Maja Živkovic, Sasa Sega Jazbec, et al. "Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis." PLoS ONE 13, br. 1 (2018): 1-7. https://doi.org/10.1371/journal.pone.0190601

Lavtar, P., et al. (2018) 'Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis', PLoS ONE, 13(1), str. 1-7. doi: 10.1371/journal.pone.0190601

Lavtar P, Rudolf G, Maver A, Hodžić A, Čizmarević NS, Živkovic M, i sur.. Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis. PLoS ONE [Internet]. 18.01.2018. [pristupljeno 07.12.2024.];13(1):1-7. doi: 10.1371/journal.pone.0190601

P. Lavtar, et al., "Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis", PLoS ONE, vol. 13, br. 1, str. 1-7, Siječanj 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:136979. [Citirano: 07.12.2024.]

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Naslov (engleski)Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis
AutorPolona Lavtar
AutorGorazd Rudolf
AutorAles Maver
AutorAlenka Hodžić
AutorNada Starčević Čizmarević
AutorMaja Živkovic
AutorSasa Sega Jazbec
AutorZalika Klemenc Ketis
AutorMiljenko Kapović
AutorEvica Dinčić
AutorRanko Raičević
AutorJuraj Sepčić
AutorLuca Lovrečić
AutorAleksandra Stanković
AutorSmiljana Ristić
MBZ: 142283
AutorBorut Peterlin
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku biologiju i genetiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Genetika, genomika i proteomika čovjeka
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Neurologija
Sažetak (engleski)
Prevalence of multiple sclerosis varies with geographic latitude. We hypothesized that this fact might be partially associated with the influence of latitude on circadian rhythm and consequently that genetic variability of key circadian rhythm regulators, ARNTL and CLOCK genes, might contribute to the risk for multiple sclerosis. Our aim was to analyse selected polymorphisms of ARNTL and CLOCK, and their association with multiple sclerosis. A total of 900 Caucasian patients and 1024 healthy controls were compared for genetic signature at 8 SNPs, 4 for each of both genes. We found a statistically significant difference in genotype (ARNTL rs3789327, P = 7.5.10(-5); CLOCK rs6811520 P = 0.02) distributions in patients and controls. The ARNTL rs3789327 CC genotype was associated with higher risk for multiple sclerosis at an OR of 1.67 (95% CI 1.35-2.07, P = 0.0001) and the CLOCK rs6811520 genotype CC at an OR of 1.40 (95% CI 1.13-1.73, P = 0.002). The results of this study suggest that genetic variability in the ARNTL and CLOCK genes might be associated with risk for multiple sclerosis.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPLoS ONE
Brojčani podacivol. 13, br. 1, str. 1-7
e-ISSN1932-6203
DOIhttps://doi.org/10.1371/journal.pone.0190601
URN:NBNurn:nbn:hr:184:136979
Datum objave publikacije2018-01-18
URL dokumentahttps://doi.org/10.1371/journal.pone.0190601
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-02-27 12:58:12