prikaz prve stranice dokumenta Decrease in Oxidative Stress Parameters after Post-Ischaemic Recombinant Human Erythropoietin Administration in the Hippocampus of Rats Exposed to Focal Cerebral Ischaemia
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Decrease in Oxidative Stress Parameters after Post-Ischaemic Recombinant Human Erythropoietin Administration in the Hippocampus of Rats Exposed to Focal Cerebral Ischaemia
Basic and Clinical Pharmacology and Toxicology, 121 (2017), 6; 453-464. https://doi.org/10.1111/bcpt.12833
Mršić-Pelčić, Jasenka; Pilipović, Kristina; Pelčić, Goran; Vitezić, Dinko; Župan, Gordana

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Mršić Pelčić, J., Pilipović, K., Pelčić, G., Vitezić, D. i Župan, G. (2017). Decrease in Oxidative Stress Parameters after Post-Ischaemic Recombinant Human Erythropoietin Administration in the Hippocampus of Rats Exposed to Focal Cerebral Ischaemia. Basic and Clinical Pharmacology and Toxicology, 121. (6), 453-464. doi: 10.1111/bcpt.12833

Mršić Pelčić, Jasenka, et al. "Decrease in Oxidative Stress Parameters after Post-Ischaemic Recombinant Human Erythropoietin Administration in the Hippocampus of Rats Exposed to Focal Cerebral Ischaemia." Basic and Clinical Pharmacology and Toxicology, vol. 121, br. 6, 2017, str. 453-464. https://doi.org/10.1111/bcpt.12833

Mršić Pelčić, Jasenka, Kristina Pilipović, Goran Pelčić, Dinko Vitezić i Gordana Župan. "Decrease in Oxidative Stress Parameters after Post-Ischaemic Recombinant Human Erythropoietin Administration in the Hippocampus of Rats Exposed to Focal Cerebral Ischaemia." Basic and Clinical Pharmacology and Toxicology 121, br. 6 (2017): 453-464. https://doi.org/10.1111/bcpt.12833

Mršić Pelčić, J., et al. (2017) 'Decrease in Oxidative Stress Parameters after Post-Ischaemic Recombinant Human Erythropoietin Administration in the Hippocampus of Rats Exposed to Focal Cerebral Ischaemia', Basic and Clinical Pharmacology and Toxicology, 121(6), str. 453-464. doi: 10.1111/bcpt.12833

Mršić Pelčić J, Pilipović K, Pelčić G, Vitezić D, Župan G. Decrease in Oxidative Stress Parameters after Post-Ischaemic Recombinant Human Erythropoietin Administration in the Hippocampus of Rats Exposed to Focal Cerebral Ischaemia. Basic and Clinical Pharmacology and Toxicology [Internet]. 12.2017. [pristupljeno 23.04.2024.];121(6):453-464. doi: 10.1111/bcpt.12833

J. Mršić Pelčić, K. Pilipović, G. Pelčić, D. Vitezić i G. Župan, "Decrease in Oxidative Stress Parameters after Post-Ischaemic Recombinant Human Erythropoietin Administration in the Hippocampus of Rats Exposed to Focal Cerebral Ischaemia", Basic and Clinical Pharmacology and Toxicology, vol. 121, br. 6, str. 453-464, Prosinac 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:219197. [Citirano: 23.04.2024.]

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Naslov (engleski)Decrease in Oxidative Stress Parameters after Post-Ischaemic Recombinant Human Erythropoietin Administration in the Hippocampus of Rats Exposed to Focal Cerebral Ischaemia
AutorJasenka Mršić-Pelčić
AutorKristina Pilipović
AutorGoran Pelčić
AutorDinko Vitezić
AutorGordana Župan
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za farmakologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Sažetak (engleski)
Recombinant human erythropoietin (rhEpo) is a multi-functional drug with antioxidant potential. However, the underlying molecular mechanisms of its action are still unclear. The purpose of this study was to investigate the effects of rhEpo on the brain infarct volume as well as on the levels of the neuronal damage, oxidative stress parameters and active caspase-3, nuclear factor erythroid 2-related factor 2 (Nrf2) and haemeoxygenase-1 (HO-1) expressions in the hippocampi of rats exposed to the right middle cerebral artery occlusion (MCAO) for 1hr. Ischaemic animals received either vehicle or rhEpo (5000IU/kg, i.p.) immediately or 3hr after the induction of ischaemia. Sham-operated, vehicle-treated animals served as the control group. Rats were killed 24hr after the onset of the ischaemic or sham experimental procedure. MCAO caused ipsilateral brain infarction within the striatum and cortex. In the CA1 region of the hippocampi, we did not find significant neuronal loss, but a statistically significant rise in the active caspase-3 and Nrf2 protein expressions was registered. We detected also significant increases in the hippocampal levels of oxidative stress parameters (thiobarbituric acid-reactive substances, superoxide dismutase, glutathione peroxidase). Post-ischaemic administration of rhEpo significantly reduced the brain infarct volume, decreased levels of all tested oxidative stress parameters and increased the Nrf2 expression level. These findings suggest that decrease in oxidative stress parameters in the hippocampus could be an early indicator of post-ischaemic neuroprotective effect of rhEpo in rats exposed to focal cerebral ischaemia and that this effect could be attributable to additional post-ischaemic activation of Nrf2 endogenous antioxidant system.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBasic and Clinical Pharmacology and Toxicology
Brojčani podacivol. 121, br. 6, str. 453-464
p-ISSN1742-7851
DOIhttps://doi.org/10.1111/bcpt.12833
URN:NBNurn:nbn:hr:184:219197
Datum objave publikacije2017-12
ProjektŠifra: 62-0620529-0518
Naziv (hrvatski): Molekularni mehanizmi ishemijskog oštećenja mozga i neuroprotekcija
Voditelj: Jasenka Mršić Pelčić
Pravna nadležnost: Hrvatska
Financijer: MZOS
ProjektŠifra: 62-0620529-0519
Naziv (hrvatski): Epilepsija i traumatska ozljeda mozga: mehanizmi oštećenja i farmakoterapija
Voditelj: Gordana Župan
Pravna nadležnost: Hrvatska
Financijer: MZOS
URL dokumentahttp://bib.irb.hr/datoteka/909186.Rad2017.pdf
Vrsta resursaTekst
Prava pristupaOgraničen pristup
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Datum i vrijeme pohrane2017-12-27 21:54:25