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Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo
Cell Reports, 19 (2017), 11; 2345-2356. https://doi.org/10.1016/j.celrep.2017.05.063
Hirche, Christoph; ...; ...; Brizić, Ilija; ...; Jonjić, Stipan; ...

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Hirche, C., Brizić, I. i Jonjić, S. (2017). Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo. Cell Reports, 19. (11), 2345-2356. doi: 10.1016/j.celrep.2017.05.063

Hirche, Christoph, et al. "Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo." Cell Reports, vol. 19, br. 11, 2017, str. 2345-2356. https://doi.org/10.1016/j.celrep.2017.05.063

Hirche, Christoph, Ilija Brizić i Stipan Jonjić. "Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo." Cell Reports 19, br. 11 (2017): 2345-2356. https://doi.org/10.1016/j.celrep.2017.05.063

Hirche, C., Brizić, I. i Jonjić, S. (2017) 'Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo', Cell Reports, 19(11), str. 2345-2356. doi: 10.1016/j.celrep.2017.05.063

Hirche C, Brizić I, Jonjić S. Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo. Cell Reports [Internet]. 13.06.2017. [pristupljeno 06.05.2024.];19(11):2345-2356. doi: 10.1016/j.celrep.2017.05.063

C. Hirche, I. Brizić i S. Jonjić, "Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo", Cell Reports, vol. 19, br. 11, str. 2345-2356, Lipanj 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:799458. [Citirano: 06.05.2024.]

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Podaci o radu
Naslov (engleski)Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo
AutorChristoph Hirche
Autor
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Autor
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AutorIlija Brizić
Autor
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AutorStipan Jonjić
Autor
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Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Quiescent long-term hematopoietic stem cells (LT-HSCs) are efficiently activated by type I interferon (IFN-I). However, this effect remains poorly investigated in the context of IFN-I-inducing virus infections. Here we report that both vesicular stomatitis virus (VSV) and murine cytomegalovirus (MCMV) infection induce LT-HSC activation that substantially differs from the effects triggered upon injection of synthetic IFN-I-inducing agents. In both infections, inflammatory responses had to exceed local thresholds within the bone marrow to confer LT-HSC cell cycle entry, and IFN-I receptor triggering was not critical for this activation. After resolution of acute MCMV infection, LT-HSCs returned to phenotypic quiescence. However, non-acute MCMV infection induced a sustained inflammatory milieu within the bone marrow that was associated with long-lasting impairment of LT-HSC function. In conclusion, our results show that systemic virus infections fundamentally affect LT-HSCs and that also non-acute inflammatory stimuli in bone marrow donors can affect the reconstitution potential of bone marrow transplants
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCell Reports
Brojčani podacivol. 19, br. 11, str. 2345-2356
p-ISSN2211-1247
DOIhttps://doi.org/10.1016/j.celrep.2017.05.063
URN:NBNurn:nbn:hr:184:799458
Datum objave publikacije2017-06-13
ProjektŠifra: 062-0621261-1263
Naziv (hrvatski): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttps://ac.els-cdn.com/S2211124717307209/1-s2.0-S2211124717307209-main.pdf?_tid=61ef015c-eae6-11e7-a977-00000aab0f6c&acdnat=1514366266_86ea78e0ed4a3c52eadaa60f50d7c382
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2017-12-27 09:15:01