prikaz prve stranice dokumenta Expression of metallothioneins in placental and fetal tissues in undisturbed and PGM-Zn treated syngeneic pregnancy
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Expression of metallothioneins in placental and fetal tissues in undisturbed and PGM-Zn treated syngeneic pregnancy
American Journal of BioScience , Special Issue: Oxidants-Antioxidants, The Biological Balance., 3 (2015), 2-2; 1-7. https://doi.org/10.11648/j.ajbio.s.2015030202.12
Jakovac, Hrvoje; Grebić, Damir; Mrakovčić-Šutić, Ines; Rukavina, Daniel; Radošević-Stašić, Biserka

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Jakovac, H., Grebić, D., Mrakovčić Šutić, I., Rukavina, D. i Radošević Stašić, B. (2015). Expression of metallothioneins in placental and fetal tissues in undisturbed and PGM-Zn treated syngeneic pregnancy. American Journal of BioScience , Special Issue: Oxidants-Antioxidants, The Biological Balance., 3. (2-2), 1-7. doi: 10.11648/j.ajbio.s.2015030202.12

Jakovac, Hrvoje, et al. "Expression of metallothioneins in placental and fetal tissues in undisturbed and PGM-Zn treated syngeneic pregnancy." American Journal of BioScience , Special Issue: Oxidants-Antioxidants, The Biological Balance., vol. 3, br. 2-2, 2015, str. 1-7. https://doi.org/10.11648/j.ajbio.s.2015030202.12

Jakovac, Hrvoje, Damir Grebić, Ines Mrakovčić Šutić, Daniel Rukavina i Biserka Radošević Stašić. "Expression of metallothioneins in placental and fetal tissues in undisturbed and PGM-Zn treated syngeneic pregnancy." American Journal of BioScience , Special Issue: Oxidants-Antioxidants, The Biological Balance. 3, br. 2-2 (2015): 1-7. https://doi.org/10.11648/j.ajbio.s.2015030202.12

Jakovac, H., et al. (2015) 'Expression of metallothioneins in placental and fetal tissues in undisturbed and PGM-Zn treated syngeneic pregnancy', American Journal of BioScience , Special Issue: Oxidants-Antioxidants, The Biological Balance., 3(2-2), str. 1-7. doi: 10.11648/j.ajbio.s.2015030202.12

Jakovac H, Grebić D, Mrakovčić Šutić I, Rukavina D, Radošević Stašić B. Expression of metallothioneins in placental and fetal tissues in undisturbed and PGM-Zn treated syngeneic pregnancy. American Journal of BioScience , Special Issue: Oxidants-Antioxidants, The Biological Balance. [Internet]. 2015. [pristupljeno 15.11.2024.];3(2-2):1-7. doi: 10.11648/j.ajbio.s.2015030202.12

H. Jakovac, D. Grebić, I. Mrakovčić Šutić, D. Rukavina i B. Radošević Stašić, "Expression of metallothioneins in placental and fetal tissues in undisturbed and PGM-Zn treated syngeneic pregnancy", American Journal of BioScience , Special Issue: Oxidants-Antioxidants, The Biological Balance., vol. 3, br. 2-2, str. 1-7, 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:865526. [Citirano: 15.11.2024.]

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Naslov (engleski)Expression of metallothioneins in placental and fetal tissues in undisturbed and PGM-Zn treated syngeneic pregnancy
AutorHrvoje Jakovac
AutorDamir Grebić
AutorInes Mrakovčić-Šutić
AutorDaniel Rukavina
AutorBiserka Radošević-Stašić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Metallothioneins (MTs) are cysteine-rich proteins, which have been implicated in regulation of physiological processes, such as cell growth, repair, differentiation, apoptosis and immunoregulation, as well as in the protection against heavy metals, oxidant damages, inflammation and other stressful conditions. To investigate their roles in physiological and detoxification processes at the maternal-fetal interface and in fetal organogenesis we examined the tissue expression of MT I/II isoforms in undisturbed syngeneic pregnancy and after the treatment with peptidoglycan monomer linked with zinc (PGM-Zn). The data showed that in undisturbed pregnancy the MTs were highly expressed at junctional zone of placenta, on endovascular trophoblast giant cells, glycogen cells and spongiotrophoblast cells, as well as on villous trophoblast cells. In the fetus they were found predominantly in the liver and in epithelial tissues, such as intestine, pancreas and kidney. Treatment with PGM-Zn markedly enhanced the intensity of MT staining both at the maternal-fetal interface and in fetal organs. The data imply that MTs are involved in the protection of trophoblast cells against the pregnancy-induced deregulation of redox and neuro-immuno-endocrine homeostasis, in transport and storage of essential metals required for fetal organogenesis, as well as in the protection of fetus against bacterial toxins.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaAmerican Journal of BioScience , Special Issue: Oxidants-Antioxidants, The Biological Balance.
Brojčani podacivol. 3, br. 2-2, str. 1-7
p-ISSN2330-0159
DOIhttps://doi.org/10.11648/j.ajbio.s.2015030202.12
URN:NBNurn:nbn:hr:184:865526
Datum objave publikacije2015
ProjektŠifra: 13.06.1.1.16
Naziv (hrvatski): Citoprotektivna i imunoregulacijska svojstva glikoproteina 96 i metalotioneina
Voditelj: Radošević-Stašić, Biserka
Pravna nadležnost: Hrvatska
Financijer: Sveučilište u Rijeci
Financijer: UNIRI
URL dokumentahttp://www.sciencepublishinggroup.com/j/ajbio
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Bez prerada 4.0 međunarodna (CC BY-ND 4.0)
Datum i vrijeme pohrane2017-11-23 20:24:15