prikaz prve stranice dokumenta NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation
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NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation
European Journal of Immunology, 47 (2017), 9; 1443-1456. https://doi.org/10.1002/eji.201646763
Miletić, Antonija; Lenartić, Maja; Popović, Branka; Brizić, Ilija; Tršan, Tihana; Miklić, Karmela; Mandelboim, Ofer; Krmpotić, Astrid; Jonjić, Stipan

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Miletić, A., Lenartić, M., Popović, B., Brizić, I., Tršan, T., Miklić, K. ... Jonjić, S. (2017). NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation. European Journal of Immunology, 47. (9), 1443-1456. doi: 10.1002/eji.201646763

Miletić, Antonija, et al. "NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation." European Journal of Immunology, vol. 47, br. 9, 2017, str. 1443-1456. https://doi.org/10.1002/eji.201646763

Miletić, Antonija, Maja Lenartić, Branka Popović, Ilija Brizić, Tihana Tršan, Karmela Miklić, Ofer Mandelboim, Astrid Krmpotić i Stipan Jonjić. "NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation." European Journal of Immunology 47, br. 9 (2017): 1443-1456. https://doi.org/10.1002/eji.201646763

Miletić, A., et al. (2017) 'NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation', European Journal of Immunology, 47(9), str. 1443-1456. doi: 10.1002/eji.201646763

Miletić A, Lenartić M, Popović B, Brizić I, Tršan T, Miklić K, i sur.. NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation. European Journal of Immunology [Internet]. 09.2017. [pristupljeno 10.12.2024.];47(9):1443-1456. doi: 10.1002/eji.201646763

A. Miletić, et al., "NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation", European Journal of Immunology, vol. 47, br. 9, str. 1443-1456, Rujan 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:522793. [Citirano: 10.12.2024.]

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Naslov (engleski)NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation
AutorAntonija Miletić
AutorMaja Lenartić
AutorBranka Popović
AutorIlija Brizić
AutorTihana Tršan
AutorKarmela Miklić
AutorOfer Mandelboim
AutorAstrid Krmpotić
AutorStipan Jonjić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Imunologija
Sažetak (engleski)
NKp46/NCR1 is an activating NK-cell receptor implicated in the control of various viral and bacterial infections. Recent findings also suggest that it plays a role in shaping the adaptive immune response to pathogens. Using NCR1-deficient (NCR1(gfp/gfp)) mice, we provide evidence for the role of NCR1 in antibody response to mouse cytomegalovirus infection (MCMV). The absence of NCR1 resulted in impaired maturation, function and NK-cell migration to regional lymph nodes. In addition, CD4(+) T-cell activation and follicular helper T-cell (Tfh) generation were reduced, leading to inferior germinal center (GC) B-cell maturation. As a consequence, NCR1(gfp/gfp) mice produced lower amounts of MCMV-specific antibodies upon infection, which correlated with lower number of virus-specific antibody secreting cells in analyzed lymph nodes.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaEuropean Journal of Immunology
Brojčani podacivol. 47, br. 9, str. 1443-1456
p-ISSN0014-2980
e-ISSN1521-4141
DOIhttps://doi.org/10.1002/eji.201646763
URN:NBNurn:nbn:hr:184:522793
Datum objave publikacije2017-09
ProjektŠifra: 062-0621261-1263
Naziv (hrvatski): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttps://onlinelibrary.wiley.com/doi/abs/10.1002/eji.201646763
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2017-10-01 18:11:14