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Molecular and Genetic Mechanisms in Melanoma
Collegium antropologicum, 32 - Supplement 2 (2008), 2; 147-152. urn:nbn:hr:184:713311
Gruber, Franjo; Kaštelan, Marija; Brajac, Ines; Saftić, Marina; Peharda, Vesna; Čabrijan, Leo; Stanić Žgombić, Zrinka; Simonić, Edita

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Gruber, F., Kaštelan, M., Brajac, I., Saftić, M., Peharda, V., Čabrijan, L. ... Simonić, E. (2008). Molecular and Genetic Mechanisms in Melanoma. Collegium antropologicum, 32 - Supplement 2. (2), 147-152. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:713311

Gruber, Franjo, et al. "Molecular and Genetic Mechanisms in Melanoma." Collegium antropologicum, vol. 32 - Supplement 2, br. 2, 2008, str. 147-152. https://urn.nsk.hr/urn:nbn:hr:184:713311

Gruber, Franjo, Marija Kaštelan, Ines Brajac, Marina Saftić, Vesna Peharda, Leo Čabrijan, Zrinka Stanić Žgombić i Edita Simonić. "Molecular and Genetic Mechanisms in Melanoma." Collegium antropologicum 32 - Supplement 2, br. 2 (2008): 147-152. https://urn.nsk.hr/urn:nbn:hr:184:713311

Gruber, F., et al. (2008) 'Molecular and Genetic Mechanisms in Melanoma', Collegium antropologicum, 32 - Supplement 2(2), str. 147-152. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:713311 (Datum pristupa: 04.05.2024.)

Gruber F, Kaštelan M, Brajac I, Saftić M, Peharda V, Čabrijan L, i sur.. Molecular and Genetic Mechanisms in Melanoma. Collegium antropologicum [Internet]. 01.10.2008. [pristupljeno 04.05.2024.];32 - Supplement 2(2):147-152. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:713311

F. Gruber, et al., "Molecular and Genetic Mechanisms in Melanoma", Collegium antropologicum, vol. 32 - Supplement 2, br. 2, str. 147-152, Listopad 2008. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:713311. [Citirano: 04.05.2024.]

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Podaci o radu
Naslov (engleski)Molecular and Genetic Mechanisms in Melanoma
AutorFranjo Gruber
AutorMarija Kaštelan
AutorInes Brajac
AutorMarina Saftić
AutorVesna Peharda
AutorLeo Čabrijan
AutorZrinka Stanić Žgombić
AutorEdita Simonić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za dermatovenerologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Dermatovenerologija
Sažetak (engleski)
Recent studies have indicated an increasing incidence of melanoma worldwide. Although UV signature mutations are found rarely in melanoma cells, there is some evidence that intense intermittent exposure to sunlight can induce melanocyte tumorigenesis, and this is also observed after UV irradiation in some animals. The purpose of this paper is to review some of the most important mechanisms involved in the pathogenesis of this tumor. Genetic studies showed the familiar melanoma is linked to the mutation or deletion of the suppressor gene CDKN2A, and perhaps to CDK4. Studies showed that BRAF mutation is frequent in primary and metastatic melanoma cells but also in naevocytic nevi. This mutation activates the RAF/MEK pathway. Exposure to UV radiation induces immunosuppression. Recent investigations showed that chemokines, angiogenesis, metalloproteinases can play a role in the mechanism of metastasis. In spite of these advances the initiating events are still not completely understood. In conclusion, the pathogenesis of melanoma is very complex because numerous genetic and epigenetic factors are implicated in its development and progression, but some of the showed mechanisms can be targets for new therapies.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCollegium antropologicum
Brojčani podacivol. 32 - Supplement 2, br. 2, str. 147-152
p-ISSN0350-6134
URN:NBNurn:nbn:hr:184:713311
Datum objave publikacije2008-10-01
URL dokumentahttp://hrcak.srce.hr/34642
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2017-08-08 11:14:16