prikaz prve stranice dokumenta Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Lung Cancer Patients
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Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Lung Cancer Patients
Genetic Testing and Molecular Biomarkers, 16 (2012), 7; 722-725. https://doi.org/10.1089/gtmb.2011.0306
Dević Pavlić, Sanja; Ristić, Smiljana; Flego, Veljko; Kapović, Miljenko; Radojčić Badovinac, Anđelka

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Dević Pavlić, S., Ristić, S., Flego, V., Kapović, M. i Radojčić Badovinac, A. (2012). Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Lung Cancer Patients. Genetic Testing and Molecular Biomarkers, 16. (7), 722-725. doi: 10.1089/gtmb.2011.0306

Dević Pavlić, Sanja, et al. "Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Lung Cancer Patients." Genetic Testing and Molecular Biomarkers, vol. 16, br. 7, 2012, str. 722-725. https://doi.org/10.1089/gtmb.2011.0306

Dević Pavlić, Sanja, Smiljana Ristić, Veljko Flego, Miljenko Kapović i Anđelka Radojčić Badovinac. "Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Lung Cancer Patients." Genetic Testing and Molecular Biomarkers 16, br. 7 (2012): 722-725. https://doi.org/10.1089/gtmb.2011.0306

Dević Pavlić, S., et al. (2012) 'Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Lung Cancer Patients', Genetic Testing and Molecular Biomarkers, 16(7), str. 722-725. doi: 10.1089/gtmb.2011.0306

Dević Pavlić S, Ristić S, Flego V, Kapović M, Radojčić Badovinac A. Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Lung Cancer Patients. Genetic Testing and Molecular Biomarkers [Internet]. 2012. [pristupljeno 25.12.2024.];16(7):722-725. doi: 10.1089/gtmb.2011.0306

S. Dević Pavlić, S. Ristić, V. Flego, M. Kapović i A. Radojčić Badovinac, "Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Lung Cancer Patients", Genetic Testing and Molecular Biomarkers, vol. 16, br. 7, str. 722-725, 2012. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:100694. [Citirano: 25.12.2024.]

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Podaci o radu
Naslov (engleski)Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Lung Cancer Patients
AutorSanja Dević Pavlić
AutorSmiljana Ristić
AutorVeljko Flego
AutorMiljenko Kapović
AutorAnđelka Radojčić Badovinac
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku biologiju i genetiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Genetika, genomika i proteomika čovjeka
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Lung cancer is a complex disease, and many factors, including environmental and occupational exposure, cigarette smoking, and genetics, contribute to its progression. Angiotensin-converting enzyme (ACE) is an important regulator of blood pressure and cardiovascular homeostasis. Plasma levels of ACE depend on an insertion/deletion (I/D) polymorphism in its gene. Current correlation data between lung cancer and the ACE I/D polymorphism are contradictory or insufficient. We investigated whether the ACE I/D polymorphism is associated with a risk for lung cancer development in the Croatian population, representing the first report in a population of Slavic origin. A total of 308 lung cancer patients and 353 control subjects were genotyped for the ACE I/D polymorphism by polymerase chain reaction. The observed distribution of genotypes and alleles showed no significant difference between total patients and controls (p>0.050). However, in a subgroup of nonsmall cell lung cancer patients with squamous cell carcinoma, a significantly higher frequency of the DD genotype (37.7% vs. 27.8%, p=0.030, OR=1.57, 95% CI=1.05–2.36) and D allele was observed compared with the control group (61.3% vs. 52.8%, p=0.015, OR=1.41, 95% CI=1.07–1.87). The DD genotype of ACE may contribute to a higher risk of developing squamous cell carcinoma in the Croatian population.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaGenetic Testing and Molecular Biomarkers
Brojčani podacivol. 16, br. 7, str. 722-725
p-ISSN1945-0265
e-ISSN1945-0257
DOIhttps://doi.org/10.1089/gtmb.2011.0306
URN:NBNurn:nbn:hr:184:100694
Datum objave publikacije2012
URL dokumentahttps://doi.org/10.1089/gtmb.2011.0306
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2017-08-02 10:20:01