prikaz prve stranice dokumenta The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription.
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The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription.
PLoS Pathogens, 13 (2017), 5; e1006382.. https://doi.org/10.1371/journal.ppat.1006382
Chan, Baca; Magalhães, V. G.; Lemmermann, N.A.W.; Juranić Lisnić, Vanda; Stempel, M.; Bussey, .K.A.; Reimer, E.; Podlech, J.; Lienenklaus, S.; Reddehase, M.J.; Jonjić, Stipan; Brinkmann, Melanie M.

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Chan, B., Magalhães, V. G., Lemmermann, N., Juranić Lisnić, V., Stempel, M., Bussey, .. ... Brinkmann, M. M. (2017). The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription.. PLoS Pathogens, 13. (5). doi: 10.1371/journal.ppat.1006382

Chan, Baca, et al. "The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription.." PLoS Pathogens, vol. 13, br. 5, 2017. https://doi.org/10.1371/journal.ppat.1006382

Chan, Baca, V. G. Magalhães, N.A.W. Lemmermann, Vanda Juranić Lisnić, M. Stempel, .K.A. Bussey, E. Reimer, et al. "The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription.." PLoS Pathogens 13, br. 5 (2017). https://doi.org/10.1371/journal.ppat.1006382

Chan, B., et al. (2017) 'The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription.', PLoS Pathogens, 13(5). doi: 10.1371/journal.ppat.1006382

Chan B, Magalhães VG, Lemmermann N, Juranić Lisnić V, Stempel M, Bussey ., i sur.. The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription.. PLoS Pathogens [Internet]. 25.05.2017. [pristupljeno 03.02.2025.];13(5). doi: 10.1371/journal.ppat.1006382

B. Chan, et al., "The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription.", PLoS Pathogens, vol. 13, br. 5, Svibanj 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:436021. [Citirano: 03.02.2025.]

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Naslov (engleski)The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription.
AutorBaca Chan
AutorV. G. Magalhães
AutorN.A.W. Lemmermann
AutorVanda Juranić Lisnić
AutorM. Stempel
Autor.K.A. Bussey
AutorE. Reimer
AutorJ. Podlech
AutorS. Lienenklaus
AutorM.J. Reddehase
AutorStipan Jonjić
AutorMelanie M. Brinkmann
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
The herpesvirus cytomegalovirus can cause severe morbidity in immunosuppressed people and poses a much greater global problem in the context of congenital infections than the Zika virus. To establish infection, cytomegalovirus needs to modulate the antiviral immune response of its host. One of the first lines of defense against viral infections is the type I interferon response which is activated by cellular sensors called pattern recognition receptors. These receptors sense viral entry and rapidly induce the transcription of type I interferons, which are instrumental for the induction of an antiviral state in infected and surrounding cells. We have identified the first viral protein encoded by murine cytomegalovirus, the M35 protein, that counteracts type I interferon transcription downstream of multiple pattern recognition receptors. We found that this viral countermeasure occurs shortly after viral entry into the host cell, as M35 is delivered with the viral particle. M35 then localizes to the nucleus where it modulates NF-κB-mediated transcription. In vivo, murine cytomegalovirus deficient of the M35 protein replicates to lower levels in spleen and liver and cannot establish a productive infection in the salivary glands, which is a key site of viral transmission, highlighting the important role of M35 for the establishment of infection. Our study provides novel insights into the complex interaction between cytomegalovirus and the innate immune response of its host.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPLoS Pathogens
Brojčani podacivol. 13, br. 5, e1006382.
p-ISSN1553-7366
e-ISSN1553-7374
DOIhttps://doi.org/10.1371/journal.ppat.1006382
URN:NBNurn:nbn:hr:184:436021
Datum objave publikacije2017-05-25
URL dokumentahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444856/pdf/ppat.1006382.pdf
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2017-06-19 16:31:57