prikaz prve stranice dokumenta Association of Variable Number of Tandem Repeats in the Coding Region of the FAM46A Gene, FAM46A rs11040 SNP and BAG6 rs3117582 SNP with Susceptibility to Tuberculosis
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Association of Variable Number of Tandem Repeats in the Coding Region of the FAM46A Gene, FAM46A rs11040 SNP and BAG6 rs3117582 SNP with Susceptibility to Tuberculosis
PLoS ONE, 9 (2014), 3; e91385. urn:nbn:hr:184:010146
Etobeke, Godfrey Essien; Bulat-Kardum, Ljiljana; Munthe, Lidvig Andre; Balen, Sanja; Dembić, Zlatko

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Etobeke, G. E., Bulat Kardum, Lj., Munthe, L. A., Balen, S. i Dembić, Z. (2014). Association of Variable Number of Tandem Repeats in the Coding Region of the FAM46A Gene, FAM46A rs11040 SNP and BAG6 rs3117582 SNP with Susceptibility to Tuberculosis. PLoS ONE, 9. (3). Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:010146

Etobeke, Godfrey Essien, et al. "Association of Variable Number of Tandem Repeats in the Coding Region of the FAM46A Gene, FAM46A rs11040 SNP and BAG6 rs3117582 SNP with Susceptibility to Tuberculosis." PLoS ONE, vol. 9, br. 3, 2014. https://urn.nsk.hr/urn:nbn:hr:184:010146

Etobeke, Godfrey Essien, Ljiljana Bulat Kardum, Lidvig Andre Munthe, Sanja Balen i Zlatko Dembić. "Association of Variable Number of Tandem Repeats in the Coding Region of the FAM46A Gene, FAM46A rs11040 SNP and BAG6 rs3117582 SNP with Susceptibility to Tuberculosis." PLoS ONE 9, br. 3 (2014). https://urn.nsk.hr/urn:nbn:hr:184:010146

Etobeke, G. E., et al. (2014) 'Association of Variable Number of Tandem Repeats in the Coding Region of the FAM46A Gene, FAM46A rs11040 SNP and BAG6 rs3117582 SNP with Susceptibility to Tuberculosis', PLoS ONE, 9(3). Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:010146 (Datum pristupa: 13.04.2024.)

Etobeke GE, Bulat Kardum Lj, Munthe LA, Balen S, Dembić Z. Association of Variable Number of Tandem Repeats in the Coding Region of the FAM46A Gene, FAM46A rs11040 SNP and BAG6 rs3117582 SNP with Susceptibility to Tuberculosis. PLoS ONE [Internet]. 13.03.2014. [pristupljeno 13.04.2024.];9(3). Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:010146

G. E. Etobeke, Lj. Bulat Kardum, L. A. Munthe, S. Balen i Z. Dembić, "Association of Variable Number of Tandem Repeats in the Coding Region of the FAM46A Gene, FAM46A rs11040 SNP and BAG6 rs3117582 SNP with Susceptibility to Tuberculosis", PLoS ONE, vol. 9, br. 3, Ožujak 2014. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:010146. [Citirano: 13.04.2024.]

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Naslov (engleski)Association of Variable Number of Tandem Repeats in the Coding Region of the FAM46A Gene, FAM46A rs11040 SNP and BAG6 rs3117582 SNP with Susceptibility to Tuberculosis
AutorGodfrey Essien Etobeke
AutorLjiljana Bulat-Kardum
AutorLidvig Andre Munthe
AutorSanja Balen
MBZ: 236875
AutorZlatko Dembić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za kliničko-laboratorijsku dijagnostiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
We analyzed for association between the Family with sequence similarity 46, member A (FAM46A) gene (located on chromosome 6q14.1), BCL2-Associated Athanogene 6 (BAG6) gene (located on chromosome 6p21.3) and tuberculosis in Croatian Caucasian. We genotyped the FAM46A rs11040 SNP, FAM46A VNTR and BAG6 rs3117582 polymorphisms in a case-control study with 257 tuberculosis patients and 493 healthy individuals in a Croatian Caucasian population. We found that genotype FAM46A 3/3 (three VNTR repeats homozygote) was associated with susceptibility to tuberculosis (p<0.0015, Pcorr.<0.029, Odds ratio = 2.42, 95% Confidence Interval = 1.34–4.3). This association suggests that the protein domain encoded by the VNTR might be important for the function of the FAM46A protein, which, in turn, could be relevant in developing tuberculosis. In addition, we found that FAM46A rs11040 SNP:FAM46A VNTR:BAG6 haplotype 132 (G-3-C) is associated with susceptibility to tuberculosis (p<0.012, pcorr.<0.024, Odds ratio 3.45, 95% Confidence Interval = 1.26–9.74). This may suggests that the interaction between the FAM46A and BAG6 proteins may be involved in tuberculosis etiology. We found also that infection of human macrophages with heat-killed M. tuberculosis (H37Rv) led to over-expression of FAM46A (VNTR 3/4) transcript. This is the first study to show associations between the FAM46A gene VNTR polymorphisms, FAM46A rs11040 SNP:FAM46A VNTR:BAG6 haplotypes and any disease.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPLoS ONE
Brojčani podacivol. 9, br. 3, e91385
e-ISSN1932-6203
URN:NBNurn:nbn:hr:184:010146
Datum objave publikacije2014-03-13
URL dokumentahttps://doi.org/10.1371/journal.pone.0091385
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2017-05-19 15:31:55