prikaz prve stranice dokumenta Comparative Analysis of Controlled Ovarian Hyperstimulation and Modified Natural Cycle Protocols on Gene Expression and Quality of Oocytes, Zygotes, and Embryos in Assisted Reproductive Technology (ART)
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Comparative Analysis of Controlled Ovarian Hyperstimulation and Modified Natural Cycle Protocols on Gene Expression and Quality of Oocytes, Zygotes, and Embryos in Assisted Reproductive Technology (ART)
International Journal of Molecular Sciences, 25 (2024), 24; 13287. https://doi.org/10.3390/ijms252413287
Dević Pavlić, Sanja; Saftić Martinović, Lara; Sušanj Šepić, Tina; Radojčić Badovinac, Anđelka

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Dević Pavlić, S., Saftić Martinović, L., Sušanj Šepić, T. i Radojčić Badovinac, A. (2024). Comparative Analysis of Controlled Ovarian Hyperstimulation and Modified Natural Cycle Protocols on Gene Expression and Quality of Oocytes, Zygotes, and Embryos in Assisted Reproductive Technology (ART). International Journal of Molecular Sciences, 25. (24). doi: 10.3390/ijms252413287

Dević Pavlić, Sanja, et al. "Comparative Analysis of Controlled Ovarian Hyperstimulation and Modified Natural Cycle Protocols on Gene Expression and Quality of Oocytes, Zygotes, and Embryos in Assisted Reproductive Technology (ART)." International Journal of Molecular Sciences, vol. 25, br. 24, 2024. https://doi.org/10.3390/ijms252413287

Dević Pavlić, Sanja, Lara Saftić Martinović, Tina Sušanj Šepić i Anđelka Radojčić Badovinac. "Comparative Analysis of Controlled Ovarian Hyperstimulation and Modified Natural Cycle Protocols on Gene Expression and Quality of Oocytes, Zygotes, and Embryos in Assisted Reproductive Technology (ART)." International Journal of Molecular Sciences 25, br. 24 (2024). https://doi.org/10.3390/ijms252413287

Dević Pavlić, S., et al. (2024) 'Comparative Analysis of Controlled Ovarian Hyperstimulation and Modified Natural Cycle Protocols on Gene Expression and Quality of Oocytes, Zygotes, and Embryos in Assisted Reproductive Technology (ART)', International Journal of Molecular Sciences, 25(24). doi: 10.3390/ijms252413287

Dević Pavlić S, Saftić Martinović L, Sušanj Šepić T, Radojčić Badovinac A. Comparative Analysis of Controlled Ovarian Hyperstimulation and Modified Natural Cycle Protocols on Gene Expression and Quality of Oocytes, Zygotes, and Embryos in Assisted Reproductive Technology (ART). International Journal of Molecular Sciences [Internet]. 11.12.2024. [pristupljeno 27.12.2024.];25(24). doi: 10.3390/ijms252413287

S. Dević Pavlić, L. Saftić Martinović, T. Sušanj Šepić i A. Radojčić Badovinac, "Comparative Analysis of Controlled Ovarian Hyperstimulation and Modified Natural Cycle Protocols on Gene Expression and Quality of Oocytes, Zygotes, and Embryos in Assisted Reproductive Technology (ART)", International Journal of Molecular Sciences, vol. 25, br. 24, Prosinac 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:644781. [Citirano: 27.12.2024.]

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Naslov (engleski)Comparative Analysis of Controlled Ovarian Hyperstimulation and Modified Natural Cycle Protocols on Gene Expression and Quality of Oocytes, Zygotes, and Embryos in Assisted Reproductive Technology (ART)
AutorSanja Dević Pavlić
AutorLara Saftić Martinović
AutorTina Sušanj Šepić
AutorAnđelka Radojčić Badovinac
Autorova ustanovaSveučilište u Rijeci
(Fakultet biotehnologije i razvoja lijekova)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za ginekologiju i opstetriciju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku biologiju i genetiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Genetika, genomika i proteomika čovjeka
Sažetak (engleski)
This study investigated the influence of two in vitro fertilization (IVF) protocols—controlled ovarian hyperstimulation (COH) and a modified natural cycle protocol—on gene expression levels (Anti-Müllerian Hormone (AMH), Anti-Müllerian Hormone Receptor Type 2 (AMHAMHR2), Follicle-Stimulating Hormone Receptor (FSHR), and Androgen Receptor (AR)) and the subsequent reproductive outcomes of assisted reproductive technology (ART). Gene expression, as well as oocyte, zygote, and embryo morphological parameters, were analyzed to evaluate the differences between the protocols. Our findings show that AMH expression was significantly associated with successful fertilization, while AMHAMHR2 expression correlated with improved embryo transfer outcomes. The modified natural cycle protocol demonstrated a higher association with the favorable gene expression profiles, particularly for AMH and AMHAMHR2, linked to successful fertilization and embryo transfer, suggesting potential advantages of minimal intervention. However, the overall quality scores for the oocytes, zygotes, and embryos were comparable between the protocols. The trend of a higher transfer success for the natural cycle, though not statistically significant, indicated potential protocol effects on the uterine environment. This study highlights the complexity of ART outcomes and suggests that incorporating gene expression markers with protocol adjustments may optimize individual ART strategies.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 25, br. 24, 13287
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms252413287
URN:NBNurn:nbn:hr:184:644781
Datum objave publikacije2024-12-11
URL dokumentahttps://www.mdpi.com/1422-0067/25/24/13287
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-12-13 09:54:27