prikaz prve stranice dokumenta Association of 25(OH)-Vitamin D3 Serum Concentrations and Vitamin D Receptor Gene Variants with the Risk of Idiopathic Spontaneous Preterm Birth in the Croatian Population
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Association of 25(OH)-Vitamin D3 Serum Concentrations and Vitamin D Receptor Gene Variants with the Risk of Idiopathic Spontaneous Preterm Birth in the Croatian Population
International Journal of Molecular Sciences, 25 (2024), 21; 11712. https://doi.org/10.3390/ijms252111712
Gašparović Krpina, Milena; Dević Pavlić, Sanja; Mladenić, Tea; Aralica, Merica; Barišić, Anita; Brnčić-Fischer, Alemka; Ostojić, Saša; Pereza, Nina

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Gašparović Krpina, M., Dević Pavlić, S., Mladenić, T., Aralica, M., Barišić, A., Brnčić Fischer, A. ... Pereza, N. (2024). Association of 25(OH)-Vitamin D3 Serum Concentrations and Vitamin D Receptor Gene Variants with the Risk of Idiopathic Spontaneous Preterm Birth in the Croatian Population. International Journal of Molecular Sciences, 25. (21). doi: 10.3390/ijms252111712

Gašparović Krpina, Milena, et al. "Association of 25(OH)-Vitamin D3 Serum Concentrations and Vitamin D Receptor Gene Variants with the Risk of Idiopathic Spontaneous Preterm Birth in the Croatian Population." International Journal of Molecular Sciences, vol. 25, br. 21, 2024. https://doi.org/10.3390/ijms252111712

Gašparović Krpina, Milena, Sanja Dević Pavlić, Tea Mladenić, Merica Aralica, Anita Barišić, Alemka Brnčić Fischer, Saša Ostojić i Nina Pereza. "Association of 25(OH)-Vitamin D3 Serum Concentrations and Vitamin D Receptor Gene Variants with the Risk of Idiopathic Spontaneous Preterm Birth in the Croatian Population." International Journal of Molecular Sciences 25, br. 21 (2024). https://doi.org/10.3390/ijms252111712

Gašparović Krpina, M., et al. (2024) 'Association of 25(OH)-Vitamin D3 Serum Concentrations and Vitamin D Receptor Gene Variants with the Risk of Idiopathic Spontaneous Preterm Birth in the Croatian Population', International Journal of Molecular Sciences, 25(21). doi: 10.3390/ijms252111712

Gašparović Krpina M, Dević Pavlić S, Mladenić T, Aralica M, Barišić A, Brnčić Fischer A, i sur.. Association of 25(OH)-Vitamin D3 Serum Concentrations and Vitamin D Receptor Gene Variants with the Risk of Idiopathic Spontaneous Preterm Birth in the Croatian Population. International Journal of Molecular Sciences [Internet]. 31.10.2024. [pristupljeno 02.12.2024.];25(21). doi: 10.3390/ijms252111712

M. Gašparović Krpina, et al., "Association of 25(OH)-Vitamin D3 Serum Concentrations and Vitamin D Receptor Gene Variants with the Risk of Idiopathic Spontaneous Preterm Birth in the Croatian Population", International Journal of Molecular Sciences, vol. 25, br. 21, Listopad 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:597602. [Citirano: 02.12.2024.]

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Podaci o radu
Naslov (engleski)Association of 25(OH)-Vitamin D3 Serum Concentrations and Vitamin D Receptor Gene Variants with the Risk of Idiopathic Spontaneous Preterm Birth in the Croatian Population
AutorMilena Gašparović Krpina
AutorSanja Dević Pavlić
AutorTea Mladenić
AutorMerica Aralica
AutorAnita Barišić
AutorAlemka Brnčić-Fischer
AutorSaša Ostojić
AutorNina Pereza
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za ginekologiju i opstetriciju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za kliničko-laboratorijsku dijagnostiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku biologiju i genetiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Ginekologija i opstetricija
Sažetak (engleski)
Preterm birth (PTB) forms a heterogeneous group with possible genetic predisposition. 25(OH)-vitamin D3 plays a significant role during implantation, placentation, and the maintenance of normal pregnancy. The aim of our research was to examine whether FokI, Cdx2, and ApaI VDR gene variants, as well as serum concentrations of 25-hydroxy25(OH)-vitamin D3 in women and their newborns, might be predisposing factors for idiopathic spontaneous preterm birth. The patient group consisted of 44 pairs of women with ISPTB and their children, and the control group consisted of 44 pairs of women who delivered at term and their children. At the time of delivery, peripheral blood was collected from every woman, and after newborn delivery, umbilical cord blood was collected. For genotyping of the rs2228570 C/T, rs11568820 G/A, and rs7975232 T/G SNPs, a combination of polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) was used. Serum concentrations of 25(OH)-vitamin D3 were determined using high-performance liquid chromatography (HPLC). There were no statistically significant differences in the frequencies of VDR genotypes and alleles between women with ISPTB and control women. There was a statistically significant difference in the distribution of VDR Cdx-2 (rs11568820) genotypes between preterm-born children and controls, with the GG genotype and G allele being more prevalent among patients than controls (p < 0.001). There were no statistically significant differences in mean values between women with ISPTB and control women, nor between preterm and full-term newborns, although the 25(OH)-vitamin D3 concentrations in preterm-born children were lower than in controls. Furthermore, there was a statistically significant correlation in 25(OH)-vitamin D3 concentrations between mothers and children both in the patient and in the control groups (b = 0.771, p < 0.001). The results of our study demonstrate a notable association between the VDR Cdx2 gene polymorphism and idiopathic spontaneous preterm birth (ISPTB) in a Caucasian population, but because of the small number of participants, further research is needed.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 25, br. 21, 11712
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms252111712
URN:NBNurn:nbn:hr:184:597602
Datum objave publikacije2024-10-31
URL dokumentahttps://www.mdpi.com/1422-0067/25/21/11712
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-11-13 08:10:23