prikaz prve stranice dokumenta Combinatory Effect of Nitroxoline and Gentamicin in the Control of Uropathogenic Enterococci Infections
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Combinatory Effect of Nitroxoline and Gentamicin in the Control of Uropathogenic Enterococci Infections
Antibiotics, 13 (2024), 9; 829. https://doi.org/10.3390/antibiotics13090829
Repac Antić, Davorka; Kovač, Bruno; Kolenc, Marko; Brčić Karačonji, Irena; Gobin, Ivana; Petković Didović, Mirna

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Repac Antić, D., Kovač, B., Kolenc, M., Brčić Karačonji, I., Gobin, I. i Petković Didović, M. (2024). Combinatory Effect of Nitroxoline and Gentamicin in the Control of Uropathogenic Enterococci Infections. Antibiotics, 13. (9). doi: 10.3390/antibiotics13090829

Repac Antić, Davorka, et al. "Combinatory Effect of Nitroxoline and Gentamicin in the Control of Uropathogenic Enterococci Infections." Antibiotics, vol. 13, br. 9, 2024. https://doi.org/10.3390/antibiotics13090829

Repac Antić, Davorka, Bruno Kovač, Marko Kolenc, Irena Brčić Karačonji, Ivana Gobin i Mirna Petković Didović. "Combinatory Effect of Nitroxoline and Gentamicin in the Control of Uropathogenic Enterococci Infections." Antibiotics 13, br. 9 (2024). https://doi.org/10.3390/antibiotics13090829

Repac Antić, D., et al. (2024) 'Combinatory Effect of Nitroxoline and Gentamicin in the Control of Uropathogenic Enterococci Infections', Antibiotics, 13(9). doi: 10.3390/antibiotics13090829

Repac Antić D, Kovač B, Kolenc M, Brčić Karačonji I, Gobin I, Petković Didović M. Combinatory Effect of Nitroxoline and Gentamicin in the Control of Uropathogenic Enterococci Infections. Antibiotics [Internet]. 01.09.2024. [pristupljeno 11.11.2024.];13(9). doi: 10.3390/antibiotics13090829

D. Repac Antić, B. Kovač, M. Kolenc, I. Brčić Karačonji, I. Gobin i M. Petković Didović, "Combinatory Effect of Nitroxoline and Gentamicin in the Control of Uropathogenic Enterococci Infections", Antibiotics, vol. 13, br. 9, Rujan 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:139298. [Citirano: 11.11.2024.]

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Naslov (engleski)Combinatory Effect of Nitroxoline and Gentamicin in the Control of Uropathogenic Enterococci Infections
AutorDavorka Repac Antić
AutorBruno Kovač
AutorMarko Kolenc
AutorIrena Brčić Karačonji
AutorIvana Gobin
AutorMirna Petković Didović
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku kemiju, biokemiju i kliničku kemiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za mikrobiologiju i parazitologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Medicinska mikrobiologija
Sažetak (engleski)
Enterococcus faecalis, responsible for a majority of human and nosocomial enterococcal infections, is intrinsically resistant to aminoglycoside antibiotics (such as gentamicin, GEN), which must be used in a combined therapy to be effective. Nitroxoline (NTX) is an old antibiotic, underused for decades, but rediscovered now in an era of growing antibiotic resistance. In this in vitro study, the types of interactions between NTX and GEN on 29 E. faecalis strains were analyzed with an aim to find synergistic antimicrobial and antiadhesion combinations. Transmission electron microscopy (TEM) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) were used to analyze changes in cell morphology and bacterial proteome after monotreatments and combined treatments. The results showed the synergistic effect for six combinations on eight strains, including the ATCC29212, and an additive effect for most strains. Combinations causing a complete inhibition of adhesion were established. Cell membrane integrity was affected by NTX, while combined NTX/GEN treatment caused dramatic changes in cell morphology. Upregulation of the expression of many proteins was established, with some emerging only after combined treatment. The results strongly imply that NTX has the potential for use in combined therapy with GEN against enterococci and it could further provide a substantial contribution to an ongoing fight against antimicrobial resistance and nosocomial infections.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaAntibiotics
Brojčani podacivol. 13, br. 9, 829
e-ISSN2079-6382
DOIhttps://doi.org/10.3390/antibiotics13090829
URN:NBNurn:nbn:hr:184:139298
Datum objave publikacije2024-09-01
ProjektŠifra: KK.01.1.1.02.0007
Naziv (hrvatski): Istraživačko-edukacijski centar za zdravstvenu i medicinsku ekologiju i zaštitu od zračenja – Rekonstrukcija i dogradnja Instituta za medicinska istraživanja i medicinu rada u Zagrebu
Naziv (engleski): Research and Educational Centre of Environmental Health and Radiation Protection – Reconstruction and Expansion of the Institute for Medical Research and Occupational Health in Zagreb
Kratica: ReC-IMI
Voditelj: Ana Lucić Vrdoljak
Pravna nadležnost: eu
Financijer: Europska komisija
Linija financiranja: European Regional Development Fund
URL dokumentahttps://www.mdpi.com/2079-6382/13/9/829
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-09-05 10:10:37