Research goal: The prospective and randomized research aimed to evaluate the diagnostic quality and stability of five bowel segments distension (jejunum, ileum, terminal ileum, cecum, and the remaining colon) in patients with Crohn's disease and a control group of healthy subjects, using magnetic resonance enterocolonography (MREC). Subjects and Methods: we included 164 patients, while the control group consisted of 55 healthy volunteers. After bowel preparation, the subjects were randomized into subgroups depending on time ingesting oral contrast medium 30, 45, 60, 75, and 90 minutes before the start of the MR examination. During the examination, an enema and spasmolytic were applied, and bowel distension was assessed by two experienced radiologists. The study was conducted from 2013. to 2015. at the Clinical Hospital Centre Rijeka. Results: The study did not find a significant difference in small bowel distension between patients with Crohn's disease and the control group, indicating the clinical applicability of the method. The MREC method achieved jejunal diagnostic distension in 81.1% of patients and 79.2% of control group subjects, while the distension of the terminal ileum was above 94% in both groups. A water enema proved important for small bowel distension, and good distension was maintained up to 75 minutes from the beginning of oral contrast intake. Intravenous application of spasmolytic significantly improved small bowel distension, while stomach emptying was not associated with distension. Patients with a penetrating disease phenotype showed poorer ileum distension (but not terminal ileum), while the age of onset and location of changes did not affect distension. Conclusion: MR enterocolonography enables diagnostically acceptable and stable bowel distension in the time frame of 30-75 minutes from taking oral contrast to the start of scanning, with prior bowel cleansing, application of a water enema, and mandatory intravenous application of spasmolytics. MREC is applicable for imaging patients with Crohn's disease, but also in subjects without inflammatory bowel disease.