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Distinct and Dynamic Changes in the Temporal Profiles of Neurotransmitters in Drosophila melanogaster Brain following Volatilized Cocaine or Methamphetamine Administrations
Pharmaceuticals, 16 (2023), 10; 1489. https://doi.org/10.3390/ph16101489
Filošević Vujnović, Ana; Saftić Martinović, Lara; Medija, Marta; Andretić Waldowski, Rozi

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Filošević Vujnović, A., Saftić Martinović, L., Medija, M. i Andretić Waldowski, R. (2023). Distinct and Dynamic Changes in the Temporal Profiles of Neurotransmitters in Drosophila melanogaster Brain following Volatilized Cocaine or Methamphetamine Administrations. Pharmaceuticals, 16. (10). doi: 10.3390/ph16101489

Filošević Vujnović, Ana, et al. "Distinct and Dynamic Changes in the Temporal Profiles of Neurotransmitters in Drosophila melanogaster Brain following Volatilized Cocaine or Methamphetamine Administrations." Pharmaceuticals, vol. 16, br. 10, 2023. https://doi.org/10.3390/ph16101489

Filošević Vujnović, Ana, Lara Saftić Martinović, Marta Medija i Rozi Andretić Waldowski. "Distinct and Dynamic Changes in the Temporal Profiles of Neurotransmitters in Drosophila melanogaster Brain following Volatilized Cocaine or Methamphetamine Administrations." Pharmaceuticals 16, br. 10 (2023). https://doi.org/10.3390/ph16101489

Filošević Vujnović, A., et al. (2023) 'Distinct and Dynamic Changes in the Temporal Profiles of Neurotransmitters in Drosophila melanogaster Brain following Volatilized Cocaine or Methamphetamine Administrations', Pharmaceuticals, 16(10). doi: 10.3390/ph16101489

Filošević Vujnović A, Saftić Martinović L, Medija M, Andretić Waldowski R. Distinct and Dynamic Changes in the Temporal Profiles of Neurotransmitters in Drosophila melanogaster Brain following Volatilized Cocaine or Methamphetamine Administrations. Pharmaceuticals [Internet]. 19.10.2023. [pristupljeno 19.11.2024.];16(10). doi: 10.3390/ph16101489

A. Filošević Vujnović, L. Saftić Martinović, M. Medija i R. Andretić Waldowski, "Distinct and Dynamic Changes in the Temporal Profiles of Neurotransmitters in Drosophila melanogaster Brain following Volatilized Cocaine or Methamphetamine Administrations", Pharmaceuticals, vol. 16, br. 10, Listopad 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:625006. [Citirano: 19.11.2024.]

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Naslov (engleski)Distinct and Dynamic Changes in the Temporal Profiles of Neurotransmitters in Drosophila melanogaster Brain following Volatilized Cocaine or Methamphetamine Administrations
AutorAna Filošević Vujnović
AutorLara Saftić Martinović
AutorMarta Medija
AutorRozi Andretić Waldowski
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za farmakologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Due to similarities in genetics, cellular response, and behavior, Drosophila is used as a model organism in addiction research. A well-described behavioral response examined in flies is the induced increase in locomotor activity after a single dose of volatilized cocaine (vCOC) and volatilized methamphetamine (vMETH), the sensitivity, and the escalation of the locomotor response after the repeated dose, the locomotor sensitization. However, knowledge about how vCOC and vMETH affect different neurotransmitter systems over time is scarce. We used LC-MS/MS to systematically examine changes in the concentration of neurotransmitters, metabolites and non-metabolized COC and METH in the whole head homogenates of male flies one to seven hours after single and double vCOC or vMETH administrations. vMETH leads to complex changes in the levels of examined substances over time, while vCOC strongly and briefly increases concentrations of dopamine, tyramine and octopamine followed by a delayed degradation into N-acetyl dopamine and N-acetyl tyramine. The first exposure to psychostimulants leads to significant and dynamic changes in the concentrations relative to the second administration when they are more stable over several hours. Further investigations are needed to understand neurochemical and molecular changes post-psychostimulant administration.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPharmaceuticals
Brojčani podacivol. 16, br. 10, 1489
e-ISSN1424-8247
DOIhttps://doi.org/10.3390/ph16101489
URN:NBNurn:nbn:hr:184:625006
Datum objave publikacije2023-10-19
URL dokumentahttps://www.mdpi.com/1424-8247/16/10/1489
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2023-11-13 09:24:56