prikaz prve stranice dokumenta Early immunological events in postoperative epidural/intravenous analgesia after colorectal cancer resection
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Znanstveni rad - Prethodno/kratko priopćenje
Early immunological events in postoperative epidural/intravenous analgesia after colorectal cancer resection
Periodicum biologorum, 115 (2013), 2; 231-233. urn:nbn:hr:184:739688
Golubović, Snježana; Golubović, Vesna; Šutić, Ivana; Pavišić, Valentino; Šustić, Alan; Mrakovčić-Šutić, Ines

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Golubović, S., Golubović, V., Šutić, I., Pavišić, V., Šustić, A. i Mrakovčić Šutić, I. (2013). Early immunological events in postoperative epidural/intravenous analgesia after colorectal cancer resection. Periodicum biologorum, 115. (2), 231-233. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:739688

Golubović, Snježana, et al. "Early immunological events in postoperative epidural/intravenous analgesia after colorectal cancer resection." Periodicum biologorum, vol. 115, br. 2, 2013, str. 231-233. https://urn.nsk.hr/urn:nbn:hr:184:739688

Golubović, Snježana, Vesna Golubović, Ivana Šutić, Valentino Pavišić, Alan Šustić i Ines Mrakovčić Šutić. "Early immunological events in postoperative epidural/intravenous analgesia after colorectal cancer resection." Periodicum biologorum 115, br. 2 (2013): 231-233. https://urn.nsk.hr/urn:nbn:hr:184:739688

Golubović, S., et al. (2013) 'Early immunological events in postoperative epidural/intravenous analgesia after colorectal cancer resection', Periodicum biologorum, 115(2), str. 231-233. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:739688 (Datum pristupa: 19.11.2024.)

Golubović S, Golubović V, Šutić I, Pavišić V, Šustić A, Mrakovčić Šutić I. Early immunological events in postoperative epidural/intravenous analgesia after colorectal cancer resection. Periodicum biologorum [Internet]. 2013. [pristupljeno 19.11.2024.];115(2):231-233. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:739688

S. Golubović, V. Golubović, I. Šutić, V. Pavišić, A. Šustić i I. Mrakovčić Šutić, "Early immunological events in postoperative epidural/intravenous analgesia after colorectal cancer resection", Periodicum biologorum, vol. 115, br. 2, str. 231-233, 2013. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:739688. [Citirano: 19.11.2024.]

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Podaci o radu
Naslov (engleski)Early immunological events in postoperative epidural/intravenous analgesia after colorectal cancer resection
AutorSnježana Golubović
AutorVesna Golubović
AutorIvana Šutić
AutorValentino Pavišić
AutorAlan Šustić
AutorInes Mrakovčić-Šutić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za anesteziologiju, reanimatologiju, hitnu i intenzivnu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Anesteziologija i reanimatologija
Sažetak (engleski)
Background and purpose: Postoperative pain is a common consequence of extensive surgery with activation of the nervous system for the implementation of pain (nociceptive system), tissue injury or inflammation. As a result of tissue injury, many different mediators are released from damaged tissues, immunocompetent cells, sympathetic and sensory fibers which directly or indirectly activate nociceptors. Postoperative pain leads to suppression of the immune system, including reduced activity of NK cells, cytotoxic T lymphocytes and macrophages. Patients and Methods: We examined the effects of epidural and intravenous analgesia in patients after colorectal cancer surgery on the immune system. We analyzed the phenotype of isolated peripheral blood mononuclear cells of patients during first six postoperative days by flow cytometry and compared them with healthy volunteers. Results: Application of intravenous analgesia leads to statistically significant decreasing in the percentage of cells of innate immunity in comparison with them after epidural analgesia. Intravenous analgesia has led to a statistically significant reduction of subpopulation of T lymphocytes (CD3+) and B lymphocytes (CD19+) on the 6th postoperative day compared to epidural analgesia. Conclusion: Intravenous analgesia after colorectal cancer surgery has led to a statistically significant greater depression of innate and acquired immunity in comparison to epidural analgesia.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Prethodno/kratko priopćenje
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPeriodicum biologorum
Brojčani podacivol. 115, br. 2, str. 231-233
p-ISSN0031-5362
e-ISSN1849-0964
URN:NBNurn:nbn:hr:184:739688
Datum objave publikacije2013
URL dokumentahttps://hrcak.srce.hr/105987
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Datum i vrijeme pohrane2023-11-02 09:29:09