prikaz prve stranice dokumenta VEGF Expression is Associated with Negative Estrogen Receptor Status in Patients with Breast Cancer
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VEGF Expression is Associated with Negative Estrogen Receptor Status in Patients with Breast Cancer
International Journal of Surgical Pathology, 14 (2016), 1; 49-55. https://doi.org/10.1177/106689690601400109
Fučkar, Dora; Dekanić, Andrea; Štifter, Sanja; Mustać, Elvira; Krstulja, Mira; Dobrila, Fran; Jonjić, Nives

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Fučkar, D., Dekanić, A., Štifter, S., Mustać, E., Krstulja, M., Dobrila, F. i Jonjić, N. (2016). VEGF Expression is Associated with Negative Estrogen Receptor Status in Patients with Breast Cancer. International Journal of Surgical Pathology, 14. (1), 49-55. doi: 10.1177/106689690601400109

Fučkar, Dora, et al. "VEGF Expression is Associated with Negative Estrogen Receptor Status in Patients with Breast Cancer." International Journal of Surgical Pathology, vol. 14, br. 1, 2016, str. 49-55. https://doi.org/10.1177/106689690601400109

Fučkar, Dora, Andrea Dekanić, Sanja Štifter, Elvira Mustać, Mira Krstulja, Fran Dobrila i Nives Jonjić. "VEGF Expression is Associated with Negative Estrogen Receptor Status in Patients with Breast Cancer." International Journal of Surgical Pathology 14, br. 1 (2016): 49-55. https://doi.org/10.1177/106689690601400109

Fučkar, D., et al. (2016) 'VEGF Expression is Associated with Negative Estrogen Receptor Status in Patients with Breast Cancer', International Journal of Surgical Pathology, 14(1), str. 49-55. doi: 10.1177/106689690601400109

Fučkar D, Dekanić A, Štifter S, Mustać E, Krstulja M, Dobrila F, i sur.. VEGF Expression is Associated with Negative Estrogen Receptor Status in Patients with Breast Cancer. International Journal of Surgical Pathology [Internet]. 27.07.2016. [pristupljeno 19.11.2024.];14(1):49-55. doi: 10.1177/106689690601400109

D. Fučkar, et al., "VEGF Expression is Associated with Negative Estrogen Receptor Status in Patients with Breast Cancer", International Journal of Surgical Pathology, vol. 14, br. 1, str. 49-55, Srpanj 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:518507. [Citirano: 19.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:518507
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Podaci o radu
Naslov (engleski)VEGF Expression is Associated with Negative Estrogen Receptor Status in Patients with Breast Cancer
AutorDora Fučkar
AutorAndrea Dekanić
AutorSanja Štifter
AutorElvira Mustać
AutorMira Krstulja
AutorFran Dobrila
AutorNives Jonjić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za kirurgiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za opću patologiju i patološku anatomiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Kirurgija
Sažetak (engleski)
The aim of this study was to analyze the association between vascular endothelial growth factor (VEGF) expression on tumor cells and other clinicopathologic parameters in breast cancer that could give additional information on its prognostic significance. Immunohistochemical analysis of expression of VEGF, estrogen (ER) and progesterone receptor (PR), HER-2/neu, and Ki67 was performed in 233 breast cancers. VEGF expression estimated semiquantitatively was correlated with all the above-mentioned parameters as well as with clinicopathologic characteristics of breast cancer such as menopausal status of patients, tumor size, histologic and nuclear grade, vascular invasion, and lymph node status. Most of the tumor cells and some stromal components expressed VEGF. A higher percentage of VEGF-positive tumor cells was present in premenopausal patients and in ER-negative tumors. In postmenopausal patients tumors with a higher expression of VEGF were associated not only with ER-negative but also with HER-2/neu-positive tumor cells. These ER-negative tumors were characterized by a higher proliferative activity. Angiogenic switch as well as proliferative activity of breast cancer cells probably are unfavorably dependent on estrogen activity. This negative correlation between VEGF expression and ER status may not only shed more light on tumor biology but may also have future therapeutic implications.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Surgical Pathology
Brojčani podacivol. 14, br. 1, str. 49-55
p-ISSN1066-8969
e-ISSN1940-2465
DOIhttps://doi.org/10.1177/106689690601400109
URN:NBNurn:nbn:hr:184:518507
Datum objave publikacije2016-07-27
URL dokumentahttp://journals.sagepub.com/doi/10.1177/106689690601400109
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-05-18 11:52:38