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Comprehensive Insight into Lichen Planus Immunopathogenesis
International Journal of Molecular Sciences, 24 (2023), 3; 3038. https://doi.org/10.3390/ijms24033038
Vičić, Marijana; Hlača, Nika; Kaštelan, Marija; Brajac, Ines; Sotošek, Vlatka; Prpić Massari, Larisa

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Vičić, M., Hlača, N., Kaštelan, M., Brajac, I., Sotošek, V. i Prpić Massari, L. (2023). Comprehensive Insight into Lichen Planus Immunopathogenesis. International Journal of Molecular Sciences, 24. (3). doi: 10.3390/ijms24033038

Vičić, Marijana, et al. "Comprehensive Insight into Lichen Planus Immunopathogenesis." International Journal of Molecular Sciences, vol. 24, br. 3, 2023. https://doi.org/10.3390/ijms24033038

Vičić, Marijana, Nika Hlača, Marija Kaštelan, Ines Brajac, Vlatka Sotošek i Larisa Prpić Massari. "Comprehensive Insight into Lichen Planus Immunopathogenesis." International Journal of Molecular Sciences 24, br. 3 (2023). https://doi.org/10.3390/ijms24033038

Vičić, M., et al. (2023) 'Comprehensive Insight into Lichen Planus Immunopathogenesis', International Journal of Molecular Sciences, 24(3). doi: 10.3390/ijms24033038

Vičić M, Hlača N, Kaštelan M, Brajac I, Sotošek V, Prpić Massari L. Comprehensive Insight into Lichen Planus Immunopathogenesis. International Journal of Molecular Sciences [Internet]. 03.02.2023. [pristupljeno 15.11.2024.];24(3). doi: 10.3390/ijms24033038

M. Vičić, N. Hlača, M. Kaštelan, I. Brajac, V. Sotošek i L. Prpić Massari, "Comprehensive Insight into Lichen Planus Immunopathogenesis", International Journal of Molecular Sciences, vol. 24, br. 3, Veljača 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:490729. [Citirano: 15.11.2024.]

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Podaci o radu
Naslov (engleski)Comprehensive Insight into Lichen Planus Immunopathogenesis
AutorMarijana Vičić
AutorNika Hlača
AutorMarija Kaštelan
AutorInes Brajac
AutorVlatka Sotošek
AutorLarisa Prpić Massari
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za anesteziologiju, reanimatologiju, hitnu i intenzivnu medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za dermatovenerologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Dermatovenerologija
Sažetak (engleski)
Lichen planus is a chronic disease affecting the skin, appendages, and mucous membranes. A cutaneous lichen planus is a rare disease occurring in less than 1% of the general population, while oral illness is up to five times more prevalent; still, both forms equally impair the patient’s quality of life. The etiology of lichen planus is not entirely understood. Yet, immune-mediated mechanisms have been recognized since environmental factors such as hepatitis virus infection, mechanical trauma, psychological stress, or microbiome changes can trigger the disease in genetically susceptible individuals. According to current understanding, lichen planus immunopathogenesis is caused by cell-mediated cytotoxicity, particularly cytotoxic T lymphocytes, whose activity is further influenced by Th1 and IL-23/Th-17 axis. However, other immunocytes and inflammatory pathways complement these mechanisms. This paper presents a comprehensive insight into the actual knowledge about lichen planus, with the causal genetic and environmental factors being discussed, the immunopathogenesis described, and the principal effectors of its inflammatory circuits identified.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 24, br. 3, 3038
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms24033038
URN:NBNurn:nbn:hr:184:490729
Datum objave publikacije2023-02-03
URL dokumentahttps://www.mdpi.com/1422-0067/24/3/3038
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-02-15 08:09:05