prikaz prve stranice dokumenta Human Decidual CD1a+ Dendritic Cells Undergo Functional Maturation Program Mediated by Gp96
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Human Decidual CD1a+ Dendritic Cells Undergo Functional Maturation Program Mediated by Gp96
International Journal of Molecular Sciences, 24 (2023), 3; 2278. https://doi.org/10.3390/ijms24032278
Gulić, Tamara; Laškarin, Gordana; Glavan, Lana; Grubić Kezele, Tanja; Haller, Herman; Rukavina, Daniel

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Gulić, T., Laškarin, G., Glavan, L., Grubić Kezele, T., Haller, H. i Rukavina, D. (2023). Human Decidual CD1a+ Dendritic Cells Undergo Functional Maturation Program Mediated by Gp96. International Journal of Molecular Sciences, 24. (3). doi: 10.3390/ijms24032278

Gulić, Tamara, et al. "Human Decidual CD1a+ Dendritic Cells Undergo Functional Maturation Program Mediated by Gp96." International Journal of Molecular Sciences, vol. 24, br. 3, 2023. https://doi.org/10.3390/ijms24032278

Gulić, Tamara, Gordana Laškarin, Lana Glavan, Tanja Grubić Kezele, Herman Haller i Daniel Rukavina. "Human Decidual CD1a+ Dendritic Cells Undergo Functional Maturation Program Mediated by Gp96." International Journal of Molecular Sciences 24, br. 3 (2023). https://doi.org/10.3390/ijms24032278

Gulić, T., et al. (2023) 'Human Decidual CD1a+ Dendritic Cells Undergo Functional Maturation Program Mediated by Gp96', International Journal of Molecular Sciences, 24(3). doi: 10.3390/ijms24032278

Gulić T, Laškarin G, Glavan L, Grubić Kezele T, Haller H, Rukavina D. Human Decidual CD1a+ Dendritic Cells Undergo Functional Maturation Program Mediated by Gp96. International Journal of Molecular Sciences [Internet]. 23.01.2023. [pristupljeno 12.11.2024.];24(3). doi: 10.3390/ijms24032278

T. Gulić, G. Laškarin, L. Glavan, T. Grubić Kezele, H. Haller i D. Rukavina, "Human Decidual CD1a+ Dendritic Cells Undergo Functional Maturation Program Mediated by Gp96", International Journal of Molecular Sciences, vol. 24, br. 3, Siječanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:412331. [Citirano: 12.11.2024.]

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Naslov (engleski)Human Decidual CD1a+ Dendritic Cells Undergo Functional Maturation Program Mediated by Gp96
AutorTamara Gulić
AutorGordana Laškarin
AutorLana Glavan
AutorTanja Grubić Kezele
AutorHerman Haller
AutorDaniel Rukavina
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za ginekologiju i opstetriciju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Imunologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Ginekologija i opstetricija
Sažetak (engleski)
Heat shock proteins (hsps), in certain circumstances, could shape unique features of decidual dendritic cells (DCs) that play a key role in inducing immunity as well as maintaining tolerance. The aim of the study was to assess the binding of gp96 to Toll-like receptor (TLR) 4 and CD91 receptors on decidual CD1a+ DCs present at the maternal-fetal interface in vitro as well as the influence of CD1a+ DCs maturation status. Immunohistology and immunofluorescence of paraffin-embedded first-trimester decidua tissue sections of normal and pathological (missed abortion MA and blighted ovum BO) pregnancies were performed together with flow cytometry detection of antigens in CD1a+ DCs after gp96 stimulation of decidual mononuclear cells. Gp96 efficiently bound CD91 and TLR4 receptors on decidual CD1a+ DCs in a dose-dependent manner and increased the expression of CD83 and HLA-DR. The highest concentration of gp96 (1000 ng/mL) increased the percentage of Interferon-γ (INF-γ) and IL-15 expressing gp96+ cells. Gp96 binds CD91 and TLR4 on decidual CD1a+ DCs, which causes their maturation and significantly increases INF-γ and IL-15 in the context of Th1 cytokine/chemokine domination, which could support immune response harmful for ongoing pregnancy.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 24, br. 3, 2278
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms24032278
URN:NBNurn:nbn:hr:184:412331
Datum objave publikacije2023-01-23
URL dokumentahttps://www.mdpi.com/1422-0067/24/3/2278
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-01-25 13:55:41