prikaz prve stranice dokumenta Boron clusters (ferrabisdicarbollides) shaping the future as radiosensitizers for multimodal (chemo/radio/PBFR) therapy of glioblastoma
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Boron clusters (ferrabisdicarbollides) shaping the future as radiosensitizers for multimodal (chemo/radio/PBFR) therapy of glioblastoma
Journal of Materials Chemistry B, (2022); 1-22. https://doi.org/10.1039/D2TB01818G
Nuez-Martínez, Miquel; Queralt-Martín, María; Muñoz-Juan, Amanda; Aguilella, Vicente M.; Laromaine, Anna; Teixidor, Francesc; Viñas, Clara; Pinto, Catarina G.; Pinheiro, Teresa; Guerreiro, Joana F.; Mendes, Filipa; Roma-Rodrigues, Catarina; Baptista, Pedro V.; Fernandes, Alexandra R.; Valić, Srećko; Marques, Fernanda Više autora...

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Nuez Martínez, M., Queralt Martín, M., Muñoz Juan, A., Aguilella, V. M., Laromaine, A., Teixidor, F. ... Marques, F. (2022). Boron clusters (ferrabisdicarbollides) shaping the future as radiosensitizers for multimodal (chemo/radio/PBFR) therapy of glioblastoma. Journal of Materials Chemistry B, 1-22. doi: 10.1039/D2TB01818G

Nuez Martínez, Miquel, et al. "Boron clusters (ferrabisdicarbollides) shaping the future as radiosensitizers for multimodal (chemo/radio/PBFR) therapy of glioblastoma." Journal of Materials Chemistry B, 2022, str. 1-22. https://doi.org/10.1039/D2TB01818G

Nuez Martínez, Miquel, María Queralt Martín, Amanda Muñoz Juan, Vicente M. Aguilella, Anna Laromaine, Francesc Teixidor, Clara Viñas, et al. "Boron clusters (ferrabisdicarbollides) shaping the future as radiosensitizers for multimodal (chemo/radio/PBFR) therapy of glioblastoma." Journal of Materials Chemistry B (2022): 1-22. https://doi.org/10.1039/D2TB01818G

Nuez Martínez, M., et al. (2022) 'Boron clusters (ferrabisdicarbollides) shaping the future as radiosensitizers for multimodal (chemo/radio/PBFR) therapy of glioblastoma', Journal of Materials Chemistry B, str. 1-22. doi: 10.1039/D2TB01818G

Nuez Martínez M, Queralt Martín M, Muñoz Juan A, Aguilella VM, Laromaine A, Teixidor F, i sur.. Boron clusters (ferrabisdicarbollides) shaping the future as radiosensitizers for multimodal (chemo/radio/PBFR) therapy of glioblastoma. Journal of Materials Chemistry B [Internet]. 2022. [pristupljeno 13.07.2024.];1-22. doi: 10.1039/D2TB01818G

M. Nuez Martínez, et al., "Boron clusters (ferrabisdicarbollides) shaping the future as radiosensitizers for multimodal (chemo/radio/PBFR) therapy of glioblastoma", Journal of Materials Chemistry B, str. 1-22, 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:188306. [Citirano: 13.07.2024.]

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Naslov (engleski)Boron clusters (ferrabisdicarbollides) shaping the future as radiosensitizers for multimodal (chemo/radio/PBFR) therapy of glioblastoma
AutorMiquel Nuez-Martínez
AutorMaría Queralt-Martín
AutorAmanda Muñoz-Juan
AutorVicente M. Aguilella
AutorAnna Laromaine
AutorFrancesc Teixidor
AutorClara Viñas
AutorCatarina G. Pinto
AutorTeresa Pinheiro
AutorJoana F. Guerreiro
AutorFilipa Mendes
AutorCatarina Roma-Rodrigues
AutorPedro V. Baptista
AutorAlexandra R. Fernandes
AutorSrećko Valić
AutorFernanda Marques
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku kemiju, biokemiju i kliničku kemiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Medicinska biokemija
Znanstveno / umjetničko
područje, polje i grana		INTERDISCIPLINARNA PODRUČJA ZNANOSTI
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
Sažetak (engleski)
Glioblastoma multiforme (GBM) is the most common and fatal primary brain tumor, and is highly resistant to conventional radiotherapy and chemotherapy. Therefore, the development of multidrug resistance and tumor recurrence are frequent. Given the poor survival with the current treatments, new therapeutic strategies are urgently needed. Radiotherapy (RT) is a common cancer treatment modality for GBM. However, there is still a need to improve RT efficiency, while reducing the severe side effects. Radiosensitizers can enhance the killing effect on tumor cells with less side effects on healthy tissues. Herein, we present our pioneering study on the highly stable and amphiphilic metallacarboranes, ferrabis(dicarbollides) ([o-FESAN] and [8, 80-I2-o-FESAN]), as potential radiosensitizers for GBM radiotherapy. We propose radiation methodologies that utilize secondary radiation emissions from iodine and iron, using ferrabis(dicarbollides) as iodine/iron donors, aiming to achieve a greater therapeutic effect than that of a conventional radiotherapy. As a proof-of-concept, we show that using 2D and 3D models of U87 cells, the cellular viability and survival were reduced using this treatment approach. We also tested for the first time the proton boron fusion reaction (PBFR) with ferrabis(dicarbollides), taking advantage of their high boron (11 B) content. The results from the cellular damage response obtained suggest that proton boron fusion radiation therapy, when combined with boron-rich compounds, is a promising modality to fight against resistant tumors. Although these results are encouraging, more developments are needed to further explore ferrabis(dicarbollides) as radiosensitizers towards a positive impact on the therapeutic strategies for GBM.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objavePrihvaćen za objavljivanje
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Materials Chemistry B
Brojčani podacistr. 1-22
p-ISSN2050-750X
e-ISSN2050-7518
DOIhttps://doi.org/10.1039/D2TB01818G
URN:NBNurn:nbn:hr:184:188306
Datum objave publikacije2022
ProjektŠifra: IP-2018-01-3168
Naziv (hrvatski): Studija važnosti spinskih međudjelovanja kao osnova za nove pristupe u istraživanju materijala
Kratica: SPES
Voditelj: Marina Ilakovac-Kveder
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
URL dokumentahttp://xlink.rsc.org/?DOI=D2TB01818G
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 3.0 (CC BY-NC 3.0)
Datum i vrijeme pohrane2022-12-02 09:38:04