prikaz prve stranice dokumenta The possible involvement of granulysin mediated cytotoxicity in keratinocytes disruption in lichen planus
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The possible involvement of granulysin mediated cytotoxicity in keratinocytes disruption in lichen planus
Medical hypotheses, 149 (2021); 110546. https://doi.org/10.1016/j.mehy.2021.110546
Vičić, Marijana; Sotošek, Vlatka; Brajac, Ines; Kaštelan, Marija; Prpić-Massari, Larisa

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Vičić, M., Sotošek, V., Brajac, I., Kaštelan, M. i Prpić Massari, L. (2021). The possible involvement of granulysin mediated cytotoxicity in keratinocytes disruption in lichen planus. Medical hypotheses, 149.. doi: 10.1016/j.mehy.2021.110546

Vičić, Marijana, et al. "The possible involvement of granulysin mediated cytotoxicity in keratinocytes disruption in lichen planus." Medical hypotheses, vol. 149, 2021. https://doi.org/10.1016/j.mehy.2021.110546

Vičić, Marijana, Vlatka Sotošek, Ines Brajac, Marija Kaštelan i Larisa Prpić Massari. "The possible involvement of granulysin mediated cytotoxicity in keratinocytes disruption in lichen planus." Medical hypotheses 149 (2021). https://doi.org/10.1016/j.mehy.2021.110546

Vičić, M., et al. (2021) 'The possible involvement of granulysin mediated cytotoxicity in keratinocytes disruption in lichen planus', Medical hypotheses, 149. doi: 10.1016/j.mehy.2021.110546

Vičić M, Sotošek V, Brajac I, Kaštelan M, Prpić Massari L. The possible involvement of granulysin mediated cytotoxicity in keratinocytes disruption in lichen planus. Medical hypotheses [Internet]. 2021. [pristupljeno 10.12.2024.];149. doi: 10.1016/j.mehy.2021.110546

M. Vičić, V. Sotošek, I. Brajac, M. Kaštelan i L. Prpić Massari, "The possible involvement of granulysin mediated cytotoxicity in keratinocytes disruption in lichen planus", Medical hypotheses, vol. 149, 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:021085. [Citirano: 10.12.2024.]

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Naslov (engleski)The possible involvement of granulysin mediated cytotoxicity in keratinocytes disruption in lichen planus
AutorMarijana Vičić
AutorVlatka Sotošek
AutorInes Brajac
AutorMarija Kaštelan
AutorLarisa Prpić-Massari
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za anesteziologiju, reanimatologiju, hitnu i intenzivnu medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za dječju stomatologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Dermatovenerologija
Sažetak (engleski)
Lichen planus is a chronic mucocutanous disorder histopathologically characterized with a keratinocytes apoptosis, subsequent basal cell layer liquefaction and accumulation of the inflammatory infiltrate in papillary dermis. A formation of apoptotic bodies in basal cell layer is due to a cytotoxic lymphocyte attack to the basal keratinocytes. It has been demonstrated that the cytotoxic molecules included in this attack are perforin and granzyme B. Both molecules are found upregulated in CD8+ lymphocytes that are in close contact to keratinocytes. However, their amount is lower in lichen planus than in other skin disease characterized by liquefaction and vacuolar degeneration of the basal epidermal layer. This could speculate about other cytotoxic molecule such as granulysin that could mediate keratinocyte apoptosis. Therefore, in this article we hypothesize about the crucial role of granulysin molecule in keratinocytes killing that could contribute to a lichen planus pathogenesis.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMedical hypotheses
Brojčani podacivol. 149, 110546
p-ISSN0306-9877
DOIhttps://doi.org/10.1016/j.mehy.2021.110546
URN:NBNurn:nbn:hr:184:021085
Datum objave publikacije2021
ProjektŠifra: uniri-biomed-18-83
Naziv (hrvatski): Uloga citotoksičnosti posredovane granulizinom i perforinom 2 u nastanku psorijaze i lihen planusa
Naziv (engleski): The role of cytotoxicity mediated by granulysin and perforin-2 in the development of psoriasis and lichen planus
Voditelj: Larisa Prpić Massari
Pravna nadležnost: Hrvatska
Financijer: NadSve
Linija financiranja: Sveučilište u Rijeci
URL dokumentahttp://bib.irb.hr/1183587
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-04-12 07:27:37