prikaz prve stranice dokumenta Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes
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Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes
Journal of Virology, 64 (1990), 11; 5457-5464. https://doi.org/10.1128/jvi.64.11.5457-5464.1990
Jonjić, Stipan; Pavić, Ivica; Lučin, Pero; Rukavina, Danijel; Koszinowski, U H

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Jonjić, S., Pavić, I., Lučin, P., Rukavina, D. i Koszinowski, U. H. (1990). Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes. Journal of Virology, 64. (11), 5457-5464. doi: 10.1128/jvi.64.11.5457-5464.1990

Jonjić, Stipan, et al. "Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes." Journal of Virology, vol. 64, br. 11, 1990, str. 5457-5464. https://doi.org/10.1128/jvi.64.11.5457-5464.1990

Jonjić, Stipan, Ivica Pavić, Pero Lučin, Danijel Rukavina i U H Koszinowski. "Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes." Journal of Virology 64, br. 11 (1990): 5457-5464. https://doi.org/10.1128/jvi.64.11.5457-5464.1990

Jonjić, S., et al. (1990) 'Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes', Journal of Virology, 64(11), str. 5457-5464. doi: 10.1128/jvi.64.11.5457-5464.1990

Jonjić S, Pavić I, Lučin P, Rukavina D, Koszinowski UH. Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes. Journal of Virology [Internet]. 11.1990. [pristupljeno 04.12.2024.];64(11):5457-5464. doi: 10.1128/jvi.64.11.5457-5464.1990

S. Jonjić, I. Pavić, P. Lučin, D. Rukavina i U. H. Koszinowski, "Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes", Journal of Virology, vol. 64, br. 11, str. 5457-5464, Studeni 1990. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:486485. [Citirano: 04.12.2024.]

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Naslov (engleski)Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes
AutorStipan Jonjić
AutorIvica Pavić
AutorPero Lučin
AutorDanijel Rukavina
AutorU H Koszinowski
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Although the relative contribution of different immune effector functions to clearing tissues of cytomegalovirus is controversial, the contribution of CD8+ T lymphocytes has generally been accepted as essential. In this report, we show that under certain conditions the CD8+ T-lymphocyte subset can be dispensable for clearance of cytomegalovirus. Mice depleted of the CD8+ T-lymphocyte subset eliminated infectious virus with a clearance kinetics similar to that of normal mice. Adoptive transfer studies revealed that the limitation of virus spread required the cooperation between the CD4+ subset and other cells. Comparison between protective functions generated in fully immunocompetent and in CD8- mice demonstrated that elimination of the CD8+ subset before infection altered the quality of the antiviral immune response. The compensatory protective activity gained by CD4+ cells in CD8- mice was absent in normal mice recovering from virus infection.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Virology
Brojčani podacivol. 64, br. 11, str. 5457-5464
p-ISSN0022-538X
e-ISSN1098-5514
DOIhttps://doi.org/10.1128/jvi.64.11.5457-5464.1990
URN:NBNurn:nbn:hr:184:486485
Datum objave publikacije1990-11
URL dokumentahttps://journals.asm.org/doi/10.1128/jvi.64.11.5457-5464.1990
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-03-17 21:45:16