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The role of B cells in an early immune response to Mycobacterium bovis
Microbial Pathogenesis, 140 (2020); 1-10. https://doi.org/10.1016/j.micpath.2019.103937
Krocova, Zuzana; Plzakova, Lenka; Pavkova, Ivona; Kubelkova, Klara; Macela, Ales; Ožanič, Mateja; Marečić, Valentina; Mihelčić, Mirna; Šantić, Marina

Citirajte ovaj rad

Krocova, Z., Plzakova, L., Pavkova, I., Kubelkova, K., Macela, A., Ožanič, M. ... Šantić, M. (2020). The role of B cells in an early immune response to Mycobacterium bovis. Microbial Pathogenesis, 140., 1-10. doi: 10.1016/j.micpath.2019.103937

Krocova, Zuzana, et al. "The role of B cells in an early immune response to Mycobacterium bovis." Microbial Pathogenesis, vol. 140, 2020, str. 1-10. https://doi.org/10.1016/j.micpath.2019.103937

Krocova, Zuzana, Lenka Plzakova, Ivona Pavkova, Klara Kubelkova, Ales Macela, Mateja Ožanič, Valentina Marečić, Mirna Mihelčić i Marina Šantić. "The role of B cells in an early immune response to Mycobacterium bovis." Microbial Pathogenesis 140 (2020): 1-10. https://doi.org/10.1016/j.micpath.2019.103937

Krocova, Z., et al. (2020) 'The role of B cells in an early immune response to Mycobacterium bovis', Microbial Pathogenesis, 140, str. 1-10. doi: 10.1016/j.micpath.2019.103937

Krocova Z, Plzakova L, Pavkova I, Kubelkova K, Macela A, Ožanič M, i sur.. The role of B cells in an early immune response to Mycobacterium bovis. Microbial Pathogenesis [Internet]. 2020. [pristupljeno 19.11.2024.];140:1-10. doi: 10.1016/j.micpath.2019.103937

Z. Krocova, et al., "The role of B cells in an early immune response to Mycobacterium bovis", Microbial Pathogenesis, vol. 140, str. 1-10, 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:968723. [Citirano: 19.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:968723
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Podaci o radu
Naslov (engleski)The role of B cells in an early immune response to Mycobacterium bovis
AutorZuzana Krocova
AutorLenka Plzakova
AutorIvona Pavkova
AutorKlara Kubelkova
AutorAles Macela
AutorMateja Ožanič
AutorValentina Marečić
AutorMirna Mihelčić
AutorMarina Šantić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za mikrobiologiju i parazitologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Medicinska mikrobiologija
Sažetak (engleski)
Mycobacterium tuberculosis is the main etiological agent of tuberculosis. The Bacillus Calmette-Guérin (BCG) microbes that are primarily used as a vaccine against tuberculosis also constitute the dominant infection model for studying the interaction of mycobacteria with the host cell types. The majority of interaction experiments have been conducted using macrophages and monocytes as prototype phagocyte cell types. Here, we report that M. bovis BCG infects mouse primary B cells as well as human B cell line. The complement receptors, along with B cell receptors, are engaged in the process of bacterial entry into the host B cells. Once inside the B cells, the intracellular trafficking of BCG follows the complete endocytic pathway of the ingested particles, which is in contrast to the events taking place during ingestion of BCG by macrophages. In vivo infection of mice with M. bovis BCG activated peritoneal as well as splenic B cells to produce proinflammatory cytokines. This paper further supports the evidence that B cells are involved in a host's early interactions with intracellular bacterial pathogens and participate in the induction of innate defense responses.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaMicrobial Pathogenesis
Brojčani podacivol. 140, str. 1-10
p-ISSN0882-4010
DOIhttps://doi.org/10.1016/j.micpath.2019.103937
URN:NBNurn:nbn:hr:184:968723
Datum objave publikacije2020
URL dokumentahttp://bib.irb.hr/1053595
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-03-11 14:35:31