prikaz prve stranice dokumenta The Role of CD44 and RHAMM in Endometrial (Endometrioid Type) Cancer: An Immunohistochemical Study
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The Role of CD44 and RHAMM in Endometrial (Endometrioid Type) Cancer: An Immunohistochemical Study
Applied immunohistochemistry & molecular morphology, 27 (2019), 8; 606-612. https://doi.org/10.1097/PAI.0000000000000673.
Klarić, Marko; Haller, Herman; Brnčić Fischer, Alemka; Babarović, Emina; Prijić, Aleksandra; Eminović, Senija

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Klarić, M., Haller, H., Brnčić Fischer, A., Babarović, E., Prijić, A. i Eminović, S. (2019). The Role of CD44 and RHAMM in Endometrial (Endometrioid Type) Cancer: An Immunohistochemical Study. Applied immunohistochemistry & molecular morphology, 27. (8), 606-612. doi: 10.1097/PAI.0000000000000673.

Klarić, Marko, et al. "The Role of CD44 and RHAMM in Endometrial (Endometrioid Type) Cancer: An Immunohistochemical Study." Applied immunohistochemistry & molecular morphology, vol. 27, br. 8, 2019, str. 606-612. https://doi.org/10.1097/PAI.0000000000000673.

Klarić, Marko, Herman Haller, Alemka Brnčić Fischer, Emina Babarović, Aleksandra Prijić i Senija Eminović. "The Role of CD44 and RHAMM in Endometrial (Endometrioid Type) Cancer: An Immunohistochemical Study." Applied immunohistochemistry & molecular morphology 27, br. 8 (2019): 606-612. https://doi.org/10.1097/PAI.0000000000000673.

Klarić, M., et al. (2019) 'The Role of CD44 and RHAMM in Endometrial (Endometrioid Type) Cancer: An Immunohistochemical Study', Applied immunohistochemistry & molecular morphology, 27(8), str. 606-612. doi: 10.1097/PAI.0000000000000673.

Klarić M, Haller H, Brnčić Fischer A, Babarović E, Prijić A, Eminović S. The Role of CD44 and RHAMM in Endometrial (Endometrioid Type) Cancer: An Immunohistochemical Study. Applied immunohistochemistry & molecular morphology [Internet]. 2019. [pristupljeno 15.11.2024.];27(8):606-612. doi: 10.1097/PAI.0000000000000673.

M. Klarić, H. Haller, A. Brnčić Fischer, E. Babarović, A. Prijić i S. Eminović, "The Role of CD44 and RHAMM in Endometrial (Endometrioid Type) Cancer: An Immunohistochemical Study", Applied immunohistochemistry & molecular morphology, vol. 27, br. 8, str. 606-612, 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:726508. [Citirano: 15.11.2024.]

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Naslov (engleski)The Role of CD44 and RHAMM in Endometrial (Endometrioid Type) Cancer: An Immunohistochemical Study
AutorMarko Klarić
AutorHerman Haller
AutorAlemka Brnčić Fischer
AutorEmina Babarović
AutorAleksandra Prijić
AutorSenija Eminović
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za ginekologiju i opstetriciju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za opću patologiju i patološku anatomiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Hyaluronan controls cell migration, differentiation, and proliferation, and it is involved in tumor invasion. The extracellular matrix containing hyaluronan regulates cell behavior via cell surface receptors such as CD44 and receptor for hyaluronan-mediated motility (RHAMM, CD168). We investigated the expression of CD44 and RHAMM in tissue samples of endometrial cancer and the relation of their expression with clinicopathologic parameters of patients. In order to evaluate the value of CD44 and RHAMM as prognostic factors, we investigated the relation of their expression with patients’ survival. Our results demonstrated a statistically significant correlation with the depth of myometrial invasion, lymphovascular invasion (LVSI), The International Federation of Gynecology and Obstetrics stage of disease, and, in the case of RHAMM expression, a significant correlation with histologic tumor grade as well. CD44 expression was present in the cell membrane in all cases, but in a proportion of tumors in the cytoplasm as well. In this group of patients, we noticed a significantly greater number of cases with deeper myometrial invasion and LVSI. Finally, we sorted out the group of tumors with simultaneous strong CD44 and strong RHAMM expression, and found a statistically significant correlation with the depth of myometrial invasion and LVSI. Using an univariate analysis, we demonstrated that, in our sample of patients, CD44 expression showed a statistically significant influence on patients’ 5-year survival. However, using a multivariate Cox regression analysis, neither CD44 nor RHAMM confirmed themselves as independent prognostic factors.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaApplied immunohistochemistry & molecular morphology
Brojčani podacivol. 27, br. 8, str. 606-612
p-ISSN1541-2016
DOIhttps://doi.org/10.1097/PAI.0000000000000673.
URN:NBNurn:nbn:hr:184:726508
Datum objave publikacije2019
URL dokumentahttp://bib.irb.hr/1047298
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-03-11 14:15:31