prikaz prve stranice dokumenta Potential role of heat-shock protein 70 and interleukin-15 in the pathogenesis of threatened spontaneous abortions
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Potential role of heat-shock protein 70 and interleukin-15 in the pathogenesis of threatened spontaneous abortions
American Journal of Reproductive Immunology, 76 (2016), 2; 126-136. https://doi.org/10.1111/aji.12525
Gulić, Tamara; Laškarin, Gordana; Dominović, Marin; Glavan Gačanin, Lana; Babarović, Emina; Haller, Herman; Rukavina, Daniel

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Gulić, T., Laškarin, G., Dominović, M., Glavan Gačanin, L., Babarović, E., Haller, H. i Rukavina, D. (2016). Potential role of heat-shock protein 70 and interleukin-15 in the pathogenesis of threatened spontaneous abortions. American Journal of Reproductive Immunology, 76. (2), 126-136. doi: 10.1111/aji.12525

Gulić, Tamara, et al. "Potential role of heat-shock protein 70 and interleukin-15 in the pathogenesis of threatened spontaneous abortions." American Journal of Reproductive Immunology, vol. 76, br. 2, 2016, str. 126-136. https://doi.org/10.1111/aji.12525

Gulić, Tamara, Gordana Laškarin, Marin Dominović, Lana Glavan Gačanin, Emina Babarović, Herman Haller i Daniel Rukavina. "Potential role of heat-shock protein 70 and interleukin-15 in the pathogenesis of threatened spontaneous abortions." American Journal of Reproductive Immunology 76, br. 2 (2016): 126-136. https://doi.org/10.1111/aji.12525

Gulić, T., et al. (2016) 'Potential role of heat-shock protein 70 and interleukin-15 in the pathogenesis of threatened spontaneous abortions', American Journal of Reproductive Immunology, 76(2), str. 126-136. doi: 10.1111/aji.12525

Gulić T, Laškarin G, Dominović M, Glavan Gačanin L, Babarović E, Haller H, i sur.. Potential role of heat-shock protein 70 and interleukin-15 in the pathogenesis of threatened spontaneous abortions. American Journal of Reproductive Immunology [Internet]. 2016. [pristupljeno 27.12.2024.];76(2):126-136. doi: 10.1111/aji.12525

T. Gulić, et al., "Potential role of heat-shock protein 70 and interleukin-15 in the pathogenesis of threatened spontaneous abortions", American Journal of Reproductive Immunology, vol. 76, br. 2, str. 126-136, 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:609408. [Citirano: 27.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:609408
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Naslov (engleski)Potential role of heat-shock protein 70 and interleukin-15 in the pathogenesis of threatened spontaneous abortions
AutorTamara Gulić
AutorGordana Laškarin
AutorMarin Dominović
AutorLana Glavan Gačanin
AutorEmina Babarović
AutorHerman Haller
AutorDaniel Rukavina
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za ginekologiju i opstetriciju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za opću patologiju i patološku anatomiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
The role of HSP70 and both its constitutive (Hsc) and inducible (Hsp) forms in the pathogenesis of threatened spontaneous abortions was investigated. Immunohistology and/or immunofluorescence was used to analyze paraffin- embedded tissue sections, and reverse transcriptase-quantitative polymerase chain reaction and flow cytometry were used for analyses of decidual mononuclear cells (DMCs) and confocal microscopy for the detection of perforin, granulysin, and lysosome-associated membrane protein-1 (LAMP-1) in decidual lymphocytes (DLs). The percentage of single Hsp70+, Hsc70+, and IL-15+ cells and mRNA levels of HSP70, CD91, and TLR4 were lower in the decidua basalis in cases of threatened miscarriages compared to that in cases of normal pregnancy. In a suspension of normal DMCs, IL-15 significantly decreased the HSP70 members and TLR4 in dendritic cells, T cells, and NK cells while increasing CD91 in NK cells alone. Downregulation of Hsc70, Hsp70, and IL-15 expression at gene and/or protein levels might support the retention of fertilization products in cases of missed abortion and blighted ovum.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaAmerican Journal of Reproductive Immunology
Brojčani podacivol. 76, br. 2, str. 126-136
p-ISSN1046-7408
e-ISSN1600-0897
DOIhttps://doi.org/10.1111/aji.12525
URN:NBNurn:nbn:hr:184:609408
Datum objave publikacije2016
ProjektŠifra: 062-0620402-0376
Naziv (hrvatski): Citokini i citolitički mehanizmi tijekom rane trudnoće
Naziv (engleski): Cytokines and cytolytic mechanisms in early pregnancy
Voditelj: Daniel Rukavina
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttp://bib.irb.hr/883090
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-03-03 14:24:54