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Is there a relationship between hypomagnesemia and proton-pump inhibitors in patients on chronic hemodialysis?
European Journal of Internal Medicine, 30 (2016); 99-103. https://doi.org/10.1016/j.ejim.2016.01.026
Mikolašević, Ivana; Milić, Sandra; Štimac, Davor; Zaputović, Luka; Lukenda Žanko, Vesna; Gulin, Tonko; Jakopčić, Ivan; Klarić, Dragan; Gulin, Marijana; Orlić, Lidija

Citirajte ovaj rad

Mikolašević, I., Milić, S., Štimac, D., Zaputović, L., Lukenda Žanko, V., Gulin, T. ... Orlić, L. (2016). Is there a relationship between hypomagnesemia and proton-pump inhibitors in patients on chronic hemodialysis?. European Journal of Internal Medicine, 30., 99-103. doi: 10.1016/j.ejim.2016.01.026

Mikolašević, Ivana, et al. "Is there a relationship between hypomagnesemia and proton-pump inhibitors in patients on chronic hemodialysis?." European Journal of Internal Medicine, vol. 30, 2016, str. 99-103. https://doi.org/10.1016/j.ejim.2016.01.026

Mikolašević, Ivana, Sandra Milić, Davor Štimac, Luka Zaputović, Vesna Lukenda Žanko, Tonko Gulin, Ivan Jakopčić, Dragan Klarić, Marijana Gulin i Lidija Orlić. "Is there a relationship between hypomagnesemia and proton-pump inhibitors in patients on chronic hemodialysis?." European Journal of Internal Medicine 30 (2016): 99-103. https://doi.org/10.1016/j.ejim.2016.01.026

Mikolašević, I., et al. (2016) 'Is there a relationship between hypomagnesemia and proton-pump inhibitors in patients on chronic hemodialysis?', European Journal of Internal Medicine, 30, str. 99-103. doi: 10.1016/j.ejim.2016.01.026

Mikolašević I, Milić S, Štimac D, Zaputović L, Lukenda Žanko V, Gulin T, i sur.. Is there a relationship between hypomagnesemia and proton-pump inhibitors in patients on chronic hemodialysis?. European Journal of Internal Medicine [Internet]. 2016. [pristupljeno 15.11.2024.];30:99-103. doi: 10.1016/j.ejim.2016.01.026

I. Mikolašević, et al., "Is there a relationship between hypomagnesemia and proton-pump inhibitors in patients on chronic hemodialysis?", European Journal of Internal Medicine, vol. 30, str. 99-103, 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:726964. [Citirano: 15.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:726964
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Podaci o radu
Naslov (engleski)Is there a relationship between hypomagnesemia and proton-pump inhibitors in patients on chronic hemodialysis?
AutorIvana Mikolašević
AutorSandra Milić
AutorDavor Štimac
AutorLuka Zaputović
AutorVesna Lukenda Žanko
AutorTonko Gulin
MBZ: 355122
AutorIvan Jakopčić
AutorDragan Klarić
AutorMarijana Gulin
AutorLidija Orlić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
We investigated the association among long- term proton-pump inhibitors (PPIs) use with serum magnesium (Mg) levels in chronic hemodialysis (HD) patients, as well as possible association among PPIs use and increased risk of cardiovascular (CVD) morbidity in HD patients. Of 418 HD patients that were screened for inclusion, 136 were excluded due to incomplete medical data, duration of renal replacement therapy (RRT) for less than 12 months, use of Mg-based-phosphate binders or other Mg-based medications or either to presence of chronic increased GI losses. Among 282 patients included in the study, 170 patients were on PPIs. Serum Mg levels were significantly lower among PPI users vs. non-users (0.94±0.2vs.1.03±0.2 mmol/L ; p<0.0001). The median duration of PPIs use was 27±9.6 months (range from 12 to 108) and it was not significantly associated with Mg levels (r=0.116 ; p=0.167). Additionally, residual renal function didn’t show significant correlation with Mg concentration (r=-0.102 ; p=NS) in both groups of patients. The use of PPIs was an independent and strong predictor of low Mg concentrations even in multivariate analysis (OR 3.05 ; 95%Cl 1.2498- 7.4594, p=0.01). On the other hand, the daily dose of PPIs was not associated with low Mg levels. PPIs users had higher rate of adverse CVD events during the one year of follow-up in comparison to non-PPIs users but that difference wasn’t statistically significant (17.6%vs.10.7% ; p=0.110). We have found a significant association between PPIs use and lower serum Mg levels in chronic HD patients.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaEuropean Journal of Internal Medicine
Brojčani podacivol. 30, str. 99-103
p-ISSN0953-6205
DOIhttps://doi.org/10.1016/j.ejim.2016.01.026
URN:NBNurn:nbn:hr:184:726964
Datum objave publikacije2016
URL dokumentahttp://bib.irb.hr/797240
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
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Datum i vrijeme pohrane2022-02-23 17:29:14