prikaz prve stranice dokumenta Interleukin-17 producing decidual CD4+ T cells are not deleterious from human pregnancy when they also produce interleukin-4
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Interleukin-17 producing decidual CD4+ T cells are not deleterious from human pregnancy when they also produce interleukin-4
Clinical and Molecular Allergy, 14 (2016); 1-14. https://doi.org/10.1186/s12948-016-0039-y
Lombardelli, Letizia; Logiodice, Frederica; Aguerre-Girr, Maryse; Kullolli, Ornela; Haller, Herman; Casart, Ysabel; Berrebi, Alain; L'Faqihi-Olive, Fatima-Ezzahra; Duplan, Valerie; Romagnani, Sergio; Maggi, Enrico; Rukavina, Daniel; Le Bouteiller, Philippe; Piccinni, Marie-Pierre

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Lombardelli, L., Logiodice, F., Aguerre Girr, M., Kullolli, O., Haller, H., Casart, Y. ... Piccinni, M. P. (2016). Interleukin-17 producing decidual CD4+ T cells are not deleterious from human pregnancy when they also produce interleukin-4. Clinical and Molecular Allergy, 14., 1-14. doi: 10.1186/s12948-016-0039-y

Lombardelli, Letizia, et al. "Interleukin-17 producing decidual CD4+ T cells are not deleterious from human pregnancy when they also produce interleukin-4." Clinical and Molecular Allergy, vol. 14, 2016, str. 1-14. https://doi.org/10.1186/s12948-016-0039-y

Lombardelli, Letizia, Frederica Logiodice, Maryse Aguerre Girr, Ornela Kullolli, Herman Haller, Ysabel Casart, Alain Berrebi, et al. "Interleukin-17 producing decidual CD4+ T cells are not deleterious from human pregnancy when they also produce interleukin-4." Clinical and Molecular Allergy 14 (2016): 1-14. https://doi.org/10.1186/s12948-016-0039-y

Lombardelli, L., et al. (2016) 'Interleukin-17 producing decidual CD4+ T cells are not deleterious from human pregnancy when they also produce interleukin-4', Clinical and Molecular Allergy, 14, str. 1-14. doi: 10.1186/s12948-016-0039-y

Lombardelli L, Logiodice F, Aguerre Girr M, Kullolli O, Haller H, Casart Y, i sur.. Interleukin-17 producing decidual CD4+ T cells are not deleterious from human pregnancy when they also produce interleukin-4. Clinical and Molecular Allergy [Internet]. 2016. [pristupljeno 03.04.2025.];14:1-14. doi: 10.1186/s12948-016-0039-y

L. Lombardelli, et al., "Interleukin-17 producing decidual CD4+ T cells are not deleterious from human pregnancy when they also produce interleukin-4", Clinical and Molecular Allergy, vol. 14, str. 1-14, 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:116035. [Citirano: 03.04.2025.]

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Naslov (engleski)Interleukin-17 producing decidual CD4+ T cells are not deleterious from human pregnancy when they also produce interleukin-4
AutorLetizia Lombardelli
AutorFrederica Logiodice
AutorMaryse Aguerre-Girr
AutorOrnela Kullolli
AutorHerman Haller
AutorYsabel Casart
AutorAlain Berrebi
AutorFatima-Ezzahra L'Faqihi-Olive
AutorValerie Duplan
AutorSergio Romagnani
AutorEnrico Maggi
AutorDaniel Rukavina
AutorPhilippe Le Bouteiller
AutorMarie-Pierre Piccinni
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za ginekologiju i opstetriciju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Background: Trophoblast expressing paternal HLA- C antigens resemble a semiallograft, and could be rejected by maternal CD4+ T lymphocytes. We examined the possible role in human pregnancy of Th17 cells, known to be involved in allograft rejection and reported for this reason to be responsible for miscarriages. We also studied Th17/Th1 and Th17/Th2 cells never investigated before. We defined for the first time the role of different Th17 subpopulations at the embryo implantation site and the... Više role of HLA-G5, produced by the trophoblast/embryo, on Th17 cell differentiation. Methods:Cytokine production by CD4+ purified T cell and T clones from decidua of normal pregnancy, unexplained recurrent abortion, and ectopic pregnancy at both embryo implantation site and distant from that site were analyzed for protein and mRNA production. Antigen-specific T cell lines were derived in the presence and in the absence of HLA-G5. Results: We found an associated spontaneous production of IL-17A, IL-17F and IL-4 along with expression of CD161, CCR8 and CCR4 (Th2- and Th17-type markers) in fresh decidua CD4+ T cells during successful pregnancy. There was a prevalence of Th17/Th2 cells (producing IL-17A, IL-17F, IL-22 and IL-4) in the decidua of successful pregnancy, but the exclusive presence of Th17 (producing IL-17A, IL-17F, IL-22) and Th17/Th1 (producing IL-17A, IL-17F, IL-22 and IFN-γ) cells was found in the decidua of unexplained recurrent abortion. More importantly, we observed that Th17/Th2 cells were exclusively present at the embryo implantation site during tubal ectopic pregnancy, and that IL-4, GATA-3, IL-17A, ROR-C mRNA levels increased in tubal biopsies taken from embryo implantation sites, whereas Th17, Th17/Th1 and Th1 cells are exclusively present apart from implantation sites. Moreover, soluble HLA-G5 mediates the development of Th17/Th2 cells by increasing IL-4, IL-17A and IL-17F protein and mRNA production of CD4+ T helper cells. Conclusion: No pathogenic role of decidual Th17 cells during pregnancy was observed. Indeed, a beneficial role for these cells was observed when they also produced IL-4. HLA-G5 could be the key feature of the uterine microenvironment responsible for the development of Th17/Th2 cells, which seem to be crucial for successful embryo implantation. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaClinical and Molecular Allergy
Brojčani podacivol. 14, str. 1-14
p-ISSN1476-7961
DOIhttps://doi.org/10.1186/s12948-016-0039-y
URN:NBNurn:nbn:hr:184:116035
Datum objave publikacije2016
URL dokumentahttp://bib.irb.hr/822238
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-02-23 16:27:40
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